A skin-hypothalamus axis couples heat stress and metabolic dysfunction Heat stress activates a skin-hypothalamus axis via KLK14-dependent epigenetic reprogramming of LRRC7⁺ astrocytes, thereby exacerbating diet-induced metabolic dysfunction. Vitamin A reduces KLK14 level...

A skin-hypothalamus axis couples heat stress and metabolic dysfunction: Cell www.cell.com/cell/fulltex...

Are (professional) investors really flocking to psychedelics? Not really....

No clear signal among professional investors WRT psychedelics....

open.substack.com/pub/zendudes...

Wow!!
Molecular dissection of protein complexes isolated from sections of human brain www.biorxiv.org/content/10.6...
Also complimentary:
www.biorxiv.org/content/10.6...

Risk reshapes amygdala representation of choice Piantadosi et al. show mice flexibly adjust choices between reward options based on the punishment potential in a BLA-dependent manner. They find that BLA neuronal representation of punishment reactiv...

Risk reshapes amygdala representation of choice: Neuron www.cell.com/neuron/fullt...

Risk reshapes amygdala representation of choice Piantadosi et al. show mice flexibly adjust choices between reward options based on the punishment potential in a BLA-dependent manner. They find that BLA neuronal representation of punishment reactiv...

Risk reshapes amygdala representation of choice: Neuron www.cell.com/neuron/fullt...

Top-down control of the descending pain modulatory system drives multimodal placebo analgesia Livrizzi, Chang-Weinberg, et al. identify a cortical-brainstem circuit that mediates top-down control of pain during placebo analgesia and find that pain relief is gated by endogenous opioids in the v...

Top-down control of the descending pain modulatory system drives multimodal placebo analgesia: Neuron www.cell.com/neuron/fullt...

Meet Real-time meetings by Google. Using your browser, share your video, desktop, and presentations with teammates and customers.

I'm giving a talk on 'Molecular Glues and GPCRs'
Dr. GPCR University with Dr. Bryan Roth
Thursday, April 9 · 10:00 – 11:35 AM (America/New_York)
meet.google.com/wam-ohcu-txt

This is yuuge!

Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors: The First Direct Visualization from Mammalian Brain Tissue
www.biorxiv.org/content/10.6...

This is yuuge!

Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors: The First Direct Visualization from Mammalian Brain Tissue
www.biorxiv.org/content/10.6...

This has to be a joke

Hmmmm....if I took advantage of this at the age of 55 and quit at the age of 65 there is so much exciting science that would never have seen the light of day.
Among the most short-sighted notions I've ever encountered.
I resonate with the idea that people can age out of science but let's get real.

a large explosion with the words ka-boom written in white ALT: a large explosion with the words ka-boom written in white

Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors: The First Direct Visualization from Mammalian Brain Tissue

Ka-Booom!

Wait for it soon to be on
@biorxiv-neursci.bsky.social

#gpcr

a large explosion with the words ka-boom written in white ALT: a large explosion with the words ka-boom written in white

Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors: The First Direct Visualization from Mammalian Brain Tissue

Ka-Booom!

Wait for it soon to be on
@biorxiv-neursci.bsky.social

#gpcr

Mechanistic insights into the therapeutic properties of delta opioid receptor Integrated structural and dynamic analyses uncover strategies to target the δ-opioid receptor for improved analgesic efficacy.

Mechanistic insights into the therapeutic properties of delta opioid receptor | Science Advances www.science.org/doi/10.1126/...

a man stands in front of a white board with the words we need to read it written on it ALT: a man stands in front of a white board with the words we need to read it written on it

It’s not all DAT: harnessing the potential of organic cation transporter 3 inhibition to selectively attenuate amphetamine reinforcement and dopamine release
www.nature.com/articles/s41...

Pretreatment with the psychedelic DOI mitigates LPS-induced hippocampal inflammation and behavioral impairments in mice - PubMed Pretreatment with the psychedelic DOI mitigates LPS-induced hippocampal inflammation and behavioral impairments in mice

Intriguing finding:
Pretreatment with the psychedelic DOI mitigates LPS-induced hippocampal inflammation and behavioral impairments in mice
pubmed.ncbi.nlm.nih.gov/41872747/

a young man wearing sunglasses is adjusting his glasses . ALT: a young man wearing sunglasses is adjusting his glasses .

Cool!
www.nature.com/articles/s41...

Structural energetics of cold sensitivity - Nature Data from cryogenic electron microscopy combined with hydrogen–deuterium exchange mass spectrometry inform a mechanism for cold-evoked activation of the TRPM8 channel, providing a structural and ...

Wow!
Structural energetics of cold sensitivity
www.nature.com/articles/s41...

Graph of hormone levels in female rats by day of cycle.

Speaking of variable reporting on the impact or lack thereof of the estrous cycle on drug self-administration in rats, one factor I can’t recall seeing nailed down- light cycle.

I've felt for some time that the problem, sadly, is the coaching. How else can you explain the inexplicable losses when they are ahead by double digits in the second half?

Psychedelics = SSRI's!? Don't say I didn't tell you....

Why it will be very difficult to demonstrate superiority of psychedelics vs conventional treatment for Treatment Resistant Depression (IMHO)
open.substack.com/pub/zendudes...

Psychedelics = SSRI's!? Don't say I didn't tell you....

Why it will be very difficult to demonstrate superiority of psychedelics vs conventional treatment for Treatment Resistant Depression (IMHO)
open.substack.com/pub/zendudes...

That's a wrap!

That's a wrap!

Spravato is a BLOCKBUSTER...really? Why S-ketamine's success will (probably) not translate to psychedelics

Why 'success' with S-ketamine may not readily translate to psychedelics...
open.substack.com/pub/zendudes...

Spravato is a BLOCKBUSTER...really? Why S-ketamine's success will (probably) not translate to psychedelics

Why 'success' with S-ketamine may not readily translate to psychedelics...
open.substack.com/pub/zendudes...

Why Phase I/II trials for depression should be taken 'with a grain of salt' Can non-psychedelic 5-HT2A agonists revolutionize how we treat depression?

Why I think investing in neuroplastogens for depression is a bad bet ....unless you have very deep pockets
zendudest.substack.com/p/why-phase-...

a man is smiling with the words inquiring minds want to know behind him ALT: a man is smiling with the words inquiring minds want to know behind him

How do I do science?
open.substack.com/pub/zendudes...