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Posts by Huang Tan

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Preprint alert 🚨 (1/10) 🧵

𝘈𝘶𝘵𝘰𝘱𝘩𝘢𝘨𝘺 𝘪𝘴 𝘢 𝘱𝘢𝘳𝘢𝘥𝘰𝘹 𝘪𝘯 𝘱𝘭𝘢𝘯𝘵 𝘪𝘮𝘮𝘶𝘯𝘪𝘵𝘺:
It can promote resistance, susceptibility, or restrict cell death 🤯

So what is its actual role?

We show it acts as a spatial organizer of immunity across cell types 🌱🦠 #proteostasis

www.biorxiv.org/content/10.6...

1 week ago 106 55 7 2

Required reading for any student of genetics. A lucid and thoughtful piece on term that is far from unambiguous. I encourage sharing widely.

1 week ago 22 15 1 0

Spatial organization of plant defense at the infection front www.biorxiv.org/content/10.64898/2026.04...

2 weeks ago 20 12 0 1

Excited to see our work out in Science today! Using machine learning to identify prokaryotic immune systems www.science.org/doi/10.1126/...

2 weeks ago 94 36 5 0

/need translation unfortunately🫣

2 weeks ago 0 0 0 0
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Please check this database😂😂 webofnothing.top you can publish your “dreams” there!!!

2 weeks ago 0 0 1 0
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Reproducible pipelines There was a discussion recently on Bluesky about reproducible data analysis pipelines.

We recently had a conversation here about reproducible data analysis pipelines. I put my thoughts into a longer-form article. Whatever you do, it's critical you save and archive your final processed data right before plotting.
blog.genesmindsmachines.com/p/creating-r...

3 weeks ago 49 13 4 0
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Extensive array of endogenous giant viral elements in a polar alga shows dynamic transcriptional response to abiotic stress Schultz et al. show that polar algae harbor extensive endogenous giant virus elements that are transcriptionally active, stress responsive, and integrated into host regulatory networks, highlighting v...

Excited to share our lab's new paper in Current Biology featuring MS student Sydney Schultz's work. We show that a polar alga carries large amount of giant viral DNA in its genome, and many of the viral genes respond to stress - with implications for host adaptation.

www.cell.com/current-biol...

3 weeks ago 42 16 2 1
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Targeting redundant gene families: A multiplexed, tissue-specific CRISPR toolbox for Arabidopsis genetic screens Anfang et al. present a tissue-specific, multiplexed CRISPR toolbox for plants that uses paired sgRNAs and barcoded libraries to target redundant gene families. Applied to Arabidopsis nutrient transporters, it boosts editing efficiency and gene coverage, enabling spatially precise screens that uncover phenotypes hidden by functional redundancy.

Targeting redundant gene families: A multiplexed, tissue-specific CRISPR toolbox for Arabidopsis genetic screens

4 weeks ago 19 12 0 0
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Want to image apoplastic pH in plants? 🔬

Two new papers from our team offer a full workflow plus open access analysis tools.
Congrats to @aroessling.bsky.social, Niklas Mayle and @lguerard.bsky.social

Nature Protocols: rdcu.be/e7R2E
BMC Methods: lnkd.in/dctpWJ3X

Happy Imaging!

1 month ago 68 38 1 3
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The lab of @elkebarbez.bsky.social strikes again 👇

Cell wall charge acts as a tunable electrostatic gate controlling iron availability in roots. Really nice work linking extracellular physics with nutrient homeostasis.

1 month ago 33 18 1 1
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New insights into microbial manipulation of the plant spliceosome Abstract. Alternative splicing (AS) has emerged as a regulatory layer in plant adaptation to the environment. In particular, biotic stresses trigger a dras

In our recent review, we explore how the spliceosome is targeted by effectors from diverse plant-interacting organisms—and how these effectors can serve as powerful molecular probes to uncover the mechanisms of splicing regulation in plants.

@geminiteamlab.bsky.social

#PlantScience #RNA #Splicing

1 month ago 8 4 0 0
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RNA splicing generates a functionally specialized Rep protein isoform in geminiviruses — enabling timely control of the viral cycle. Strikingly, similar strategies might have evolved in DNA viruses infecting different kingdoms: www.biorxiv.org/content/10.6... Spearheaded by @delphinem-p.bsky.social!

2 months ago 54 35 0 1

Alternative splicing expands the functional portfolio of a plant virus to control the viral cycle www.biorxiv.org/content/10.64898/2026.02...

2 months ago 3 2 0 0

Cool story from @meristemania.bsky.social lab on growth-defense tradeoff at the shoot apical meristem www.biorxiv.org/content/10.6...

2 months ago 22 12 0 0

Highly recommended!

2 months ago 2 0 0 0
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Please share!
My group at @zmbp-tuebingen.bsky.social is offering a post-doctoral position (4 years). We look for a structural biologist with experience in Cryo-EM/Cryo-ET to investigate the mechanisms of host invasion by pathogenic fungi. Deadline February 28th!
uni-tuebingen.de/universitaet...

2 months ago 83 119 0 3
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FBI frame-up of Indiana University postdoc Youhuang Xiang: Anti-China witch-hunt escalates The arrest and prosecution of Chinese researcher Youhuang Xiang, announced December 19 by FBI Director Kash Patel, is the latest episode in an FBI/Department of Justice campaign to criminalize scienti...

FBI frame-up of Indiana University postdoc Youhuang Xiang: Anti-China witch-hunt escalates
www.wsws.org/en/articles/...
I'd heard whispers of these arrests for carrying plasmids and bio materials across borders before, but someone just shared this detailed news report with me.
Please be careful.

3 months ago 18 9 0 1

Who wore it better?

3 months ago 15 4 1 0
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Why I’m genetically engineering a rainbow flower…

And how a Russian fairy tale inspired the idea 🧵

3 months ago 71 22 3 2
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What could be better than discussing single-stranded DNA viruses with an international community of experts and a trans-kingdom perspective — at an affordable prize?

Doing it in Bahia, Brazil! 🌴🌊☀️

Join us for IS3DV, June 15-19!
isdv2026.com

3 months ago 10 4 0 1

Cell-type-specific gating of gene regulatory modules as a hallmark of early immune responses in Arabidopsis leaves nph.onlinelibrary.wiley.com/doi/10.1111/...

3 months ago 7 2 0 0
Defence-mediated phloem restriction of a plant virus facilitates insect transmission - Nature Communications How plant viruses are restricted to the phloem are long-standing questions in plant virology. The paper shows PENETRATION3 activity and callose deposition confine plant viruses to the phloem, which fa...

Why are so many plant viruses phloem-restricted? New work from Xueping Zhou’s lab reveals how this tissue tropism is determined in a geminivirus — and why phloem confinement can turn out to be an evolutionary advantage! www.nature.com/articles/s41... 🌱🦠🚷🅿️🛫🌱

3 months ago 28 12 0 0
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Xanthomonas coordinates type III–type II effector synergy by activating fruit-ripening pathway Plant cell walls harbor vast carbohydrate reserves, yet how pathogens unlock them remains unclear. We show that the citrus canker pathogen Xanthomonas citri subsp. citri (Xcc) mobilizes cell wall suga...

www.science.org/doi/10.1126/...

4 months ago 1 0 0 0

Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

4 months ago 521 222 28 31
A PhD position (initially 3 years) is available in our laboratory in the Center for Plant Molecular Biology (ZMBP), at the University of Tübingen (Germany). The position is available with an intended start date starting January 2026.
Interested applicants should submit a single PDF comprising a motivation letter describing your research interests, an up-to-date CV, and the names and contact information for 2 references to timing.lab@zmbp.uni-tuebingen.de ideally before July 21st.

A PhD position (initially 3 years) is available in our laboratory in the Center for Plant Molecular Biology (ZMBP), at the University of Tübingen (Germany). The position is available with an intended start date starting January 2026. Interested applicants should submit a single PDF comprising a motivation letter describing your research interests, an up-to-date CV, and the names and contact information for 2 references to timing.lab@zmbp.uni-tuebingen.de ideally before July 21st.

We're looking for a new PhD candidate to join the lab. Please share 🌱😄

10 months ago 83 125 3 5
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1/ Preprint alert:

🌾 The developing leaf of the wild grass Brachypodium distachyon at single-cell resolution

👉 doi.org/10.1101/2025...
A 70k-cell single-cell RNA-seq atlas of the developing grass leaf—from the shoot meristem to mature leaf tissues. @cerealcell.bsky.social @lbmountain.bsky.social

5 months ago 50 31 3 3
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Cell wall patterning regulates plant stem cell dynamics The plant cell wall regulates development through spatiotemporal modulation of its chemical and mechanical properties. Pectin methylesterification is recognized as a rheological switch controlling wal...

Out in @science.org this week:
PME5 is sequestered in the nucleus and released during cytokinesis allowing its activity to be timed with cell division.

www.science.org/doi/10.1126/...

#PlantScience
#PlantSci

4 months ago 52 22 0 1
Abstract

For the past two years, I have been contemplating how best to write this review that not only reflects on a few significant and nostalgic moments in my more than three decades of professional career in the molecular plant-microbe interaction (MPMI) field, but also offers my personal outlook on the future aimed at inspiring young scientists to join this exciting discipline. Rather than a comprehensive overview, I would like to place greater emphasis on the “whys” and the “hows” than the “whats”. I finally decided to use technological advancements critical for the development of our field as a thread to connect the past with the future.

Founder's Review

Abstract For the past two years, I have been contemplating how best to write this review that not only reflects on a few significant and nostalgic moments in my more than three decades of professional career in the molecular plant-microbe interaction (MPMI) field, but also offers my personal outlook on the future aimed at inspiring young scientists to join this exciting discipline. Rather than a comprehensive overview, I would like to place greater emphasis on the “whys” and the “hows” than the “whats”. I finally decided to use technological advancements critical for the development of our field as a thread to connect the past with the future. Founder's Review

"Leaf It to Science: Uncovering Plant Immune Systems Through Technological Advances Open Access"

Reflections on Career, #PlantScience and #PlantImmunity by Xinnian Dong

academic.oup.com/plphys/advan...

4 months ago 23 12 2 0

when it started…😎😉❤️🔥

4 months ago 12 0 0 0