Another twist to why newborn babies more vulnerable to infection. Beyond immune cell immaturity, layering, active suppression... maternal pathogen-targeted antibodies still protect. Grateful @Nature sharing this hopefully uplifting glass half (99.9%)-full perspective www.nature.com/articles/s41...
Check out this squid-vibrio postdoc position at Penn State with my colleague Tim Miyashiro, especially if you have a background in proteomics/metabolomics.
psu.wd1.myworkdayjobs.com/PSU_Academic...
If anyone interested in #postdoc #opportunities in our lab, please let us know. marie-sklodowska-curie-actions.ec.europa.eu/node/1495
May you live in interesting times...
It's just oligos that map to highly conserved DNA so one batch fits everyone. If we're going to be so dishonest to begin with, we might as well go all in 😂
People love snake oil!
If you tailor the nucleic acids to match an individuals genome, so, you know, they're replenishing themself, I'll buy shares.
Aha, that fits.
Or love it, so they don't want it treated?!
I don't understand the basis of the NIDDK cut. Surely it fits the newly stated mission re chronic diseases/"out diet is killing us" quite well. Awful is right.
Attending #BSI25? 📣 Meet our Editor-in-Chief, Simon Milling!
Join us at the BSI stand this evening (18:00–19:30) in the exhibition hall to hear more about Discovery Immunology. Come say hello! 👋
Eh, does anyone know why bovine serum albumin (from Sigma at least) has tripled in price?
Interesting 🧵. IANAE so won’t comment on the science beyond noting that phase separation (in biology) is highly contentious (see e.g. genesdev.cshlp.org/content/33/2...). But it does bring up issues around publishing and editorial decisions 1/n
Populist Dems won. Moderate Dems won. We won in blue states. We won in purple states.
Maybe the take is that (a) people think Trump is out of control; and (b) people like Dems when we're taking a stand and fighting for what we believe in - as we have been for the last month.
Love Nebraska so much, these lines always give me the chills:
"Now my ma she fingers her wedding band
And watches the salesman stare at my old man's hands
He's tellin' us all 'bout the break he'd give us
If he could but he just can't
Well if I could I swear I know just what I'd do"
2/2 So, some TCR may be more prone to become Tregs or whatnot, but without tracking responses to the same epitope for different TCR it's really hard to know if there is TCR determinism (which I have no issue with) versus some facet of the stimulation (loosely "environmental") that drives this.
1/2 This is a very nice paper but I'm not sure I agree fully with the conclusion (reading on the train on my phone, may have missed something). To my mind, this data shows that a given TCR will repeatedly adopt a particular cell fate when encountering the same antigen derived from the same source.
Happy to share new work from #theonlylabever, lead by the phenomenal @sltai.bsky.social - who developed a tool to study the biology of ILC3s, identifying their role in controlling CSF2-dependent myeloid cells. 🤗
@mucosalimmunol.bsky.social @societymucosalimm.bsky.social
OA: doi.org/10.1016/j.mu...
For the #lovers of #TCRs -we are looking for #postdocs with interest in #functional and #mutational studies -dare to express 700 #self #antigen #specific #TCRs and #study them in #depth!!!!
Was it ever alive? I joined because I heard it was like old Twitter but I never see much in the way of decent science conversation on here. Maybe people have just abandoned social media.
It's more than 20 years old, so obviously doesn't discuss many of the amazing discoveries since, prominent among them being the tissue repair functions of Tregs, identifying them as immune system regulators not merely suppressor T cells.
I've noted for a long time a desire among many to try & write particular people out of the narrative of the history of Treg research. This review, by the one person everyone agrees is pivotal, provides an accurate assessment for those who don't know the field:
www.annualreviews.org/content/jour...
Séamus Heaney was also uncontactable as he was sailing when he won for literature in '95
I think, Fiona Powrie, Ethan Shevach, Jeff Bluestone, Diane Mathis and Christoph Benoist all would lay claim too. Don Mason is dead, but he probably started his studies in the area at a similar time to Sakaguchi.
All praise to him is well warranted.
It is strange that there hasn't been an award for T cells/B cells, given that there is sufficient consensus that Miller and Cooper could share it.
The mention of Sakaguchi alone was cold, Jeff 😂
Anyone have any expertise/experience with interrogating SNP/InDel in a mouse genome using a reference genome. We have an alignment and are using Integrated Genomics Viewer, but are having trouble figuring some stuff out.
With deep gratitude, we thank Dr. Marc Jenkins for his decades of leadership, mentorship, and dedication to the Center for Immunology. The foundation he built will guide and inspire us for years to come.
Gianna Hammer & I are thrilled to co-Chair the 64th @midwinter-immun.bsky.social Conference of Immunologists Jan. 24-27, 2026. Join us & an amazing lineup of speakers including Carla Rothlin as Dan Campbell memorial lecturer for some exciting science in lovely Asilomar, CA!
www.midwconfimmunol.org