Out today in Journal of the National Cancer Institute Jonathan Spoor and colleagues show that women who have had a breast reconstruction with silicone implants as part of breast cancer treatment do not face an increased risk of developing autoimmune or rheumatic diseases
🔗 doi.org/10.1093/jnci...
The largest published prospective evaluation of off-label targeted cancer therapies is out today in Nature. Results from the Dutch multicenter DRUP trial show both the potential of this approach and the need for systematic evaluation in clinical trial settings ➡️ www.nature.com/articles/s41...
New paper in Genes & Dev: we dissected how Sox2 — a key pluripotency TF — is regulated by a distal enhancer cluster (SCR) 100 kb away. The results challenge simple models of cohesin-mediated loop extrusion of gene regulation. genesdev.cshlp.org/content/earl... 🧵
Congrats to Stefano Trebeschi on receiving an NWO Science-XS grant. His project develops symmetry-based AI to detect bone metastases on scans, with the potential to improve treatment evaluation and patient care. More:
🔗 www.nwo.nl/en/news/56-g...
We’re proud to share that our colleague @myriamchalabi.bsky.social has won the Grand Prize of the 2026 Takeda Innovators in Science Award 🏆
Her bold research in neoadjuvant immunotherapy is reshaping treatment.
Congratulations Myriam!
🎥 Watch the video here: www.youtube.com/watch?v=ch_Z...
Time to stretch our legs and enjoy the beautiful tulip fields surrounding the venue 🌷
Of course there is also time for food and enjoying the nice Dutch spring sun ☀️
Our junior PI's are presenting their new work and collaboration options for future studies
Today we are at the 2-day NKI retreat full of inspiration and connection
Macrophages play a dubious role in our body. PhD candidate Daniel Taranto found a way to prevent them from helping liver tumor cells grow in the lab. He’s still happy that his PI convinced him to persevere on his journey towards a PhD ➡️ www.nki.nl/news-events/...
@nunopadrao.bsky.social
@tinekelenstra.bsky.social
As of April 1st, our group leader Tineke Lenstra has been appointed professor by special appointment of Single cell transcription dynamics.
🎉 Congratulations Tineke Lenstra & team! We look forward to what lies ahead.
A discovery by PhD candidate Nuno Padrão forms the basis of a clinical trial for breast cancer patients initiating this year. It involves stress hormones. They trick your body into believing it’s in a caloric deficit. This is easier to sustain than fasting ➡️ www.nki.nl/news-events/...
While he was trying to solve a scientific mystery, PhD candidate Nicolaas Boon discovered the mechanism that explains how an important protein is involved in the response to chemotherapy ➡️ www.nki.nl/news-events/...
New preprint from our lab... We applied our hopping technology to relocate CTCF binding sites to thousands of alternative positions in the Sox2 locus: www.biorxiv.org/content/10.6...
A cohort of 60 mouse-intraductal patient-derived xenograft models of primary invasive breast cancer was developed to develop neoadjuvant treatments @josjonkers.bsky.social @nkinl.bsky.social
www.science.org/doi/10.1126/...
How do hormones and diet influence the outcome of #cancer therapy?
Wilbert Zwart (@zwartlab.bsky.social) of the @nkinl.bsky.social gave an amazing lecture on this topic at #KNCVMCCB2026 covering various strategies to use this information for improved treatments.
www.nature.com/articles/s41...
🧵 CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function — and it changes how we think about CTCF's role in development. 1/8 www.biorxiv.org/content/10.6...
Ever wondered how a eukaryotic transcription factor finds its specific DNA motif in the vast genome? In this preprint, we directly measured the dynamics of this search process in living cells, revealing a cooperative mechanism mediated by disordered regions. 1/10 doi.org/10.64898/202...
Now in @natmed.nature.com a review on the clinical development of cancer vaccines. It outlines how advances in antigen discovery, vaccine platforms, and combination strategies are shaping the next generation of cancer vaccines and where the field may be heading 🔗 www.nature.com/articles/s41...
New #EuropeanFairPricingNetwork research shows that some hospitals pay more than double for the exact same cancer drug.
Confidential price negotiations are leaving hospitals in the dark, weaking their bargaining power and deepening inequalities across the EU ➡️ www.nki.nl/news-events/...
We’re excited to reveal that team ILLUMINE led by Reuven Agami has been selected by Cancer Grand Challenges to to take on one of cancer’s toughest challenges. Congratulations to Reuven and all the #CancerGrandChallenges teams! ➡️nki.nl/news-events/news/illuminating-cancer-s-hidden-layer/
INDIBLADE (phase II): testing the concept of organ preservation enabled by powerful induction therapy in muscle-invasive bladder cancer. High 2-year bladder-intact event-free survival with induction immunotherapy + CRT. Now in Nature Medicine: www.nature.com/articles/s41...
🎉 Congratulations to @zwartlab.bsky.social on receiving a Vici grant from NWO Dutch Research Council for PERSEUS.
Exploring how gene regulation rewires prostate cancer and how to turn those insights into targeted therapies.
www.nwo.nl/en/news/39-r...
We;re hiring Junior Group Leaders! 🔬✨
We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment.
www.nki.nl/news-events/...
We are part of @eu-life.bsky.social together with research institutes across Europe we want to strengthen research & innovation and be a voice for research in European policy
This series highlights our shared priorities. This time #Internationality🌍 Stay tuned for the NKI’s story #WeAreEULife
Postdoc alert in spatial biology!
Building upon our previous work with MSI cancers (e.g. de Vries et al, Nature, 2023), the Voest Group at the NKI is hiring a (fully funded) postdoctoral fellow with strong expertise in spatial cancer biology.
Learn more / apply here: www.nki.nl/careers-stud...
💡“DEprot” is now out on @narjournal.bsky.social Genomics and Bioinformatics.
With Nils Eickhoff ( @zwartlab.bsky.social, @nkinl.bsky.social & @oncodeinstitute.bsky.social), we designed this “all-in-one” tool to facilitate the analyses of LFQ-based proteomics data.
academic.oup.com/nargab/artic...