A big step forward in Photopharmacology, just published in Nature Medicine:
nature.com/articles/s41...
A compound we conceptualized in 2008 (PMCID: PMC4040390) and synthesized in 2010 (PMCID: PMC3401033) proves effective in human vision restoration.
Figure 2. FORCE1s reports in vivo neuronal activity with high fidelity under resonance scanning 2-photon microscopy (A-I) 2P-guided whole-cell patching and resonant-scan imaging in anesthetized mice. (A) Experimental schematic. (B) 2P images of a representative FORCE1s-Kv-expressing neuron are shown at high resolution (i) and the size and resolution used during voltage imaging (ii). The patching pipette is outlined. (C) Simultaneous electrophysiological recording (top, 10 kHz) and FORCE1s-Kv fluorescence imaging (bottom, 440 Hz). The fluorescence trace was low-pass filtered at 150 Hz to enhance the visualization of the spikes. Dashed boxes: epochs shown in panels D-E. Vertical lines: detected spikes. Gray triangle (left, and in panels D-E): -70 mV. (D-E) Zoomed-in subthreshold (D) and bursting (E) epochs. Panel D’s optical trace was low-pass filtered at 50 Hz to enhance the visualization of subthreshold fluctuations.
This is beautiful data. 2p optical reporting of subthreshold voltage, validated with simultaneous patch clamp. www.biorxiv.org/content/10.6... FORCE1s by François St-Pierre's group, with a bunch of great people joining in.
I understand their decision but at the same time I find it harsh to apply it retrospectively. Maybe people who applied in 2025 would have made another decision if they knew they would be banned for two years instead of 1 if their project was not well ranked.
ERC : "We're overwhelmed with funding request, it's becoming unmanageable. We need to find a way to reduce the number of applications."
French Government: "You need to go get the money from Europe, you bunch of losers!"
🫣
Excited to share our new study on how the brain generates placebo pain relief!
We developed a mouse model that recapitulates key features of human placebo analgesia, then used it to identify causal circuitry.
www.sciencedirect.com/science/arti...
today.ucsd.edu/story/neurob...
1/n
New paper in Nature, @nature.com (go.nature.com/4c4OjCj) : how do social roles emerge in groups of near-identical individuals ? we find that they are neither predetermined nor fixed.
Where does anti-NMDAR autoimmune encephalitis come from? Our new work suggests that ectopic NMDAR expression in tumors can trigger anti-cancer immunity, and the resulting antibodies may drive encephalitis-like symptoms. A dynamic Janowitz-Furukawa lab collaboration. www.nature.com/articles/s41...
It indeed looks super interesting ! Congrats !
On vous attend !
Join us for a day of great science! "From boys to men: A journey through gender expectations" on April 2nd at the Paris Brain Institute #genderequity #gender #womeninleadership #alba #science #neuroskyence @institutducerveau.bsky.social
Plus d'excuses.... à bientôt !!
#SdC2026
www.semaineducerveau.fr/2026/03/16/l...
Anne Hidalgo a posté un message sur Bluesky bsky.app/profile/anne.... Mais toujours pas de résultats officiels.
J’y animerai un atelier sur l’expérimentation et le bien-être animal en recherche, en binôme avec un boucher qui vous parlera du bien-être animal chez les animaux d’élevage.
Ce lundi commence la @semaineducerveau.bsky.social . Jeudi 19 mars de 17h à 19h30, venez à « cerveau en boutique » @psl-univ.bsky.social découvrir les neurosciences auprès de commerçants de la rue Mouffetard! Plus d’infos ici 👉 psl.eu/agenda/cerve...
Neat paper from PJ and team at Institut Pasteur.
Agonist activated by light conjugated to a nanobody.
A trick way to hack receptors with light.
www.biorxiv.org/content/10.6...
Oh it’s out ! Congrats to Maria, Pierre-Jean, Alex Mourot and team members!
J’ai commandé deux ordis en octobre et je les attends toujours, j’espère que tu auras plus de chance que moi.
Claudin 24—A novel enhancer of AMPA receptor fidelity | Science Advances www.science.org/doi/10.1126/...
Ok, thanks, I will check it out!
Wow, so impressive ! Do you use a specific software to manage your library ?
Good opportunity for a grad student looking to get some industry experience before they graduate:
www.linkedin.com/jobs/view/43...
Get involved with protein expression, purification, biochemical and biophysical assays, and get familiar with the process of drug discovery!
Oyé Oyé !!!
Voici le programme de la Semaine du Cerveau à Paris et dans sa banlieue !
On vous y attend nombreuses et nombreux.
Vive le mois de mars.
Plus d'info sur : www.semaineducerveau.fr/programme-ma...
#Gratuit #Passionnant @psl-univ.bsky.social @france.theconversation.com @franceinter.fr
Pour le site de la Société des Neurosciences @socneuro.bsky.social, avec les collègues Christelle Peyron, Carole Rovere et Anne Giersch, on va lancer plus de news et de contenus courts 👀🧠
Vous avez un article récent ? Envoyez-le nous (mes DM sont ouverts) avec un bref résumé, on le mettra en avant
Et si la lumière permettait d’éteindre la douleur ? Une nouvelle étude montre qu'une brève exposition aux UV diminue la sensibilité des souris pendant plusieurs heures. Une piste inattendue pour soulager la douleur animale.
🥁Out on Ecology Letters
👉Fluctuating Growth Rates Link Turnover and Unevenness in Species-Rich Communities
🔗 onlinelibrary.wiley.com/doi/10.1111/...
👏Congatulations to Emil Mallmin, Arne Traulsen, and Silvia De Monte!
#neuroskyence #neurosci #PainResearch 🧪💊
By @physoc.bsky.social
A brilliant scientist and leader has left us. I taught about Dr. Dolphin's work on calcium channels and gabapentin in our pharmacology curriculum.
Remembering Annette Dolphin (1951 – 2026)
I am pretty sure the organizers would be thrilled to have you as an instructor…