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Posts by Colleen

FOX 12 Oregon facebook post screenshot. Headline reads "Latest Updates: 2 more arrested near Portland ICE facility Saturday." Picture shows people outsid the ICE facility in blow-up costumes, L-R: Squidward, Mr. Potato Head, not sure but it's a diapered person in a trucker hat, Garfield, again not sure, banana, lobster

FOX 12 Oregon facebook post screenshot. Headline reads "Latest Updates: 2 more arrested near Portland ICE facility Saturday." Picture shows people outsid the ICE facility in blow-up costumes, L-R: Squidward, Mr. Potato Head, not sure but it's a diapered person in a trucker hat, Garfield, again not sure, banana, lobster

Portland is showing the way. Hail Portland

6 months ago 1111 182 20 19
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Anas al-Sharif among five Al Jazeera journalists killed by Israel in Gaza Al Jazeera staff killed in targeted Israeli attack on a tent housing journalists near al-Shifa Hospital, Gaza City.

Four Al Jazeera staff, including reporter Anas Al Sharif, were killed in an Israeli attack on a tent for journalists outside the main gate of Gaza's al-Shifa hospital aje.io/onll19

8 months ago 3749 2418 142 295
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And they said we can’t agree on anything these days!

8 months ago 3231 655 79 29
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to Jews, on the Gaza famine an open letter: we have been commanded

www.lifeisasacredtext.com/gazaletter/

8 months ago 1 0 0 0
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HAPPENING NOW: a group of New York rabbis are being arrested at a protest outside the Israeli consulate calling for bringing food into Gaza, an end to the war, and return of all hostages

@newjewishnarrative.bsky.social

8 months ago 4360 1379 7 98

“May we embody a new creation where each one of us shares the gifts that we have received.”

César García, the General Secretary of Mennonite World Conference

#MennoGathering2025

9 months ago 11 3 0 0

I have one that’s a little charging STAND. Less likely to get jostled.

10 months ago 1 0 0 0
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Let me be clear:
This isn’t bullying. This is public health education.
This is science.
This is fact-checking dangerous misinformation from someone who now holds power over our nation’s health policies.

Silencing doctors who speak out is not safety—it’s censorship.

I will NOT be silenced.

10 months ago 228 16 8 1

Free. Them. All.

11 months ago 160 30 2 1
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“Do not mock us.”

11 months ago 42485 8980 2905 867

There is no “debate” about fluoride in toxicology, medicine or science. I don’t think anyone who is capable of basic critical thinking has any problem understanding. These freaks could just not buy toothpaste with fluoride but instead they very badly want to make toothpaste inaccessible to everybody

11 months ago 1640 422 52 25

This adds to the literature showing restrictive abortion laws increase infant mortality. Don’t let them lie about being “pro-life” when their policies literally kill women and children.

11 months ago 410 162 7 2

We could not become like God, so God became like us.

God showed us how to heal instead of kill, mend instead of destroy, love instead of hate, live instead of long for more.

When we nailed God to a tree, God forgave.

And when we buried God in the ground, God got up.

- Rachel Held Evans

1 year ago 182 24 7 3

Just to be clear, autistic people who can’t work or date or throw a baseball (?) still deserve to exist and have dignity and worth

1 year ago 190 47 2 1
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1 year ago 422 120 15 5
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a cartoon of homer simpson holding a card ALT: a cartoon of homer simpson holding a card

When they change the layout of a grocery store you were very familiar with

1 year ago 87 4 6 0
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Jewish Groups and Synagogues Defend Students Detained by ICE More than two dozen are joining a legal effort to free a Tufts University student the Trump administration is trying to deport because of her pro-Palestinian views.

American Jews are opposing the Trump administration's authoritarian actions against pro-Palestinian students who are being falsely accused of antisemitism: "Jewish Groups and Synagogues Defend Students Detained by ICE" www.nytimes.com/2025/04/12/u...

1 year ago 28 14 0 4
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RFK believes that he is one of the genetic elect and that it is a violation of the natural order to either impose on the genetic elect with public health OR prevent nature from taking its course with those who are predestined to biological damnation.

1 year ago 16098 3794 904 394
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1 year ago 31927 7019 262 222
ABSTRACT
Lasso peptides (biologically active molecules with a distinct structurally constrained knotted fold) are natural products that belong to the class of ribosomally synthesized and post-translationally modified peptides.
Lasso peptides act on several bacterial targets but none have been reported to inhibit the ribosome, one of the main targets of antibiotics in the bacterial cell.
Here we report the identification and characterization of the lasso peptide antibiotic lariocidin and its internally cyclized derivative lariocidin B, produced by Paenibacillus sp. M2, which has broad-spectrum activity against a range of bacterial pathogens. We show that lariocidins inhibit bacterial growth by binding to the ribosome and interfering with protein synthesis.
Structural, genetic and biochemical data show that lariocidins bind at a unique site in the small ribosomal subunit, where they interact with the 16S ribosomal RNA and aminoacyl-tRNA, inhibiting translocation and inducing miscoding.
Lariocidin is unaffected by common resistance mechanisms, has a low propensity for generating spontaneous resistance, shows no toxicity to human cells, and has potent in vivo activity in a mouse model of Acinetobacter baumannii infection.
Our identification of ribosome-targeting lasso peptides uncovers new routes towards the discovery of alternative protein-synthesis inhibitors and offers a novel chemical scaffold for the development of much-needed antibacterial drugs.

ABSTRACT Lasso peptides (biologically active molecules with a distinct structurally constrained knotted fold) are natural products that belong to the class of ribosomally synthesized and post-translationally modified peptides. Lasso peptides act on several bacterial targets but none have been reported to inhibit the ribosome, one of the main targets of antibiotics in the bacterial cell. Here we report the identification and characterization of the lasso peptide antibiotic lariocidin and its internally cyclized derivative lariocidin B, produced by Paenibacillus sp. M2, which has broad-spectrum activity against a range of bacterial pathogens. We show that lariocidins inhibit bacterial growth by binding to the ribosome and interfering with protein synthesis. Structural, genetic and biochemical data show that lariocidins bind at a unique site in the small ribosomal subunit, where they interact with the 16S ribosomal RNA and aminoacyl-tRNA, inhibiting translocation and inducing miscoding. Lariocidin is unaffected by common resistance mechanisms, has a low propensity for generating spontaneous resistance, shows no toxicity to human cells, and has potent in vivo activity in a mouse model of Acinetobacter baumannii infection. Our identification of ribosome-targeting lasso peptides uncovers new routes towards the discovery of alternative protein-synthesis inhibitors and offers a novel chemical scaffold for the development of much-needed antibacterial drugs.

Lariocidin, a lasso-shaped peptide with promising antibiotic properties. (Graphic: Dmitrii Travin and Yury Polikanov). Research: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome.

Lariocidin, a lasso-shaped peptide with promising antibiotic properties. (Graphic: Dmitrii Travin and Yury Polikanov). Research: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome.

Lariocidin hits drug-resistant bacteria where others fail- by hijacking the ribosome at a new site, bypassing defenses, and opening the door to a new generation of antibiotics.

The study has been published in Nature. YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...

1 year ago 801 167 9 16

THIS IS HUGE! Researchers at McMaster University have discovered a NEW peptide antibiotic that targets a broad range of disease-causing bacteria INCLUDING those RESISTANT to existing antibiotics. This discovery marks the first potential new class of antibiotics in NEARLY 30 YEARS. 🧪🧵⬇️

1 year ago 9278 2751 226 283
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Exclusive | FDA’s Top Vaccine Official Forced Out In his resignation letter, Dr. Peter Marks cited ‘misinformation and lies’ from Health and Human Services Secretary RFK Jr.

JUST IN: The FDA’s top vaccine official, Dr. Peter Marks, has been pushed out. In his resignation letter, he slams RFK Jr. for rejecting “truth and transparency” and pushing “misinformation and lies.” Marks warns of an “unprecedented assault on scientific truth.”

1 year ago 11133 3600 357 214
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Christ in the Rubble: Faith, the Bible, and the Genocide in Gaza Christ in the Rubble: Faith, the Bible, and the Genocide in Gaza [Isaac, Munther, Jennings, Willie James] on Amazon.com. *FREE* shipping on qualifying offers. Christ in the Rubble: Faith, the Bible, and the Genocide in Gaza

So sad to see what is happening in Gaza again.... Listen to Dr. Munther Isaac on Madang Podcast and read his book #ChristintheRubble

amzn.to/3FyV6aC

@eerdmansbooks.bsky.social

www.youtube.com/watch?v=vETH...

1 year ago 1 1 0 0
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Eastern Monarch Butterfly Population Nearly Doubles The population wintering in central Mexico's forests occupied 4.42 acres, up from 2.22 acres during the previous winter.

Who wants some good news?

The overwintering monarch population, which had plummeted last winter, has doubled this winter! www.worldwildlife.org/stories/east...

1 year ago 16418 4056 306 353
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I've Been Paralyzed Since I Was 3. Here's Why Kindness Toward Disabled People Is More Complicated Than You Think Editors Note: This is a boldly honest look at how people with paralysis have to deal with "overly kind" (well-meaning) offers of help. It's a uniquely

Please take a couple of minutes to read this piece.

It's important.

"We have ignored the perspectives, stories & voices of disabled people for so long that their actual needs, feelings and experiences are hardly acknowledged."

1 year ago 749 308 16 20
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Illegal dumping grounds off the New Jersey turnpike across from Manhattan in the 1970s

Illegal dumping grounds off the New Jersey turnpike across from Manhattan in the 1970s

Smog rolling on over Manhattan in the 1970s

Smog rolling on over Manhattan in the 1970s

This is what many cities in the U.S. looked like before the EPA.

Why the heck would anyone celebrate deregulating it?

1 year ago 10545 3521 471 227

Alina Habbard posted: NOTHING CAN STOP THIS MAN FROM FIGHTING FOR HIS COUNTRY.
David Simon had a succinct 2-word response: “Bone spurs.”

1 year ago 98525 17113 1989 794
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Criminalizing protest is a hallmark of authoritarian regimes

1 year ago 16681 4824 1036 468

My online life as a climate scientist ⬇️

2 years ago 897 179 14 3