more cool dyes! Super exciting.

hi everybody, asmita here back at it again with another preprint for your attention.

excited to share our new fluorogenic speed probes that enable whole cell 3D imaging! 🔬

Please check out our newest work on fluorogenic speed imager probes, in which we combine the strengths of speed-optimized imagers and fluorogenic imagers.

#SuperResolution #DNAPAINT #microscopy

www.biorxiv.org/content/10.6...

Gyeongju is really nice and could be a day trip!

Hi Jongmin, thanks! That's an interesting possibility. Based on the reported Polycomb abundance measurements, Polycomb protein occupancy seems likely too low to be able to block loop extrusion. It would be super interesting to look at E-P loops in cell lines +/- degrons to get more insights on this!

I had a lot of fun putting this together with @suminkim.bsky.social and @andersshansen.bsky.social! Glad to have had the chance to work on it!

Thanks also to @lucagiorgetti.bsky.social and @djost-physbiol.bsky.social for the invitation and for putting together a very interesting themed issue - the other reviews in the issue can be found here
www.sciencedirect.com/special-issu...

Happy to share our new review on Polycomb-mediated 3D chromatin interactions! Thanks to @mileshuseyin.bsky.social and @andersshansen.bsky.social for great discussions throughout the process :)

Very cool!

Xpert Protease Inhibitor Cocktail Solution (100X) The Xpert Protease Inhibitor Cocktail Solution(100X) is a specially formulated mixture of 5 protease inhibitors with broad specificity for the inhibition of various protease and esterase. Other EDTA-f...

I haven’t used these yet myself but have heard they are good! Cheaper than the cOmplete ones: gendepot.com/products/xpe... and gendepot.com/products/xpe...

Sosa Lab - Postdoctoral Researchers We are seeking postdocs to start in 2026!

The Sosa Lab is going to #SfN25 and actively recruiting ✨postdocs✨ with systems neuroscience experience! We study both fundamental memory processes and how memory changes during pregnancy and postpartum.

If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...

Amazing! Congratulations!!!! 🎉

❤️

Thank you!!

Thanks Mara!

Thank you!

Excited to be a part of this amazing community!

Genome structure mapping with high-resolution 3D genomics and deep learning Gene expression is often regulated by distal enhancers through cell-type-specific 3D looping interactions, but comprehensive mapping of these interactions across cell types is experimentally intractab...

Excited to share my first preprint from the @andersshansen.bsky.social lab! It's got genomics, AI, and biology - all wrapped up in a great paper. Also very grateful to my amazing collaborator, Fan, for all his hard work. Please check it out and let me know what you think!
tinyurl.com/bdfvtd6f

(1/n) New preprint from @claricehongky.bsky.social
Fan Fang Varshini Ramanathan in collab w Jie Liu.

Q: How do we get ultra-high-res 3D genome maps?

A: New deep learning model, Cleopatra.

Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps at ultra-high resolution.

(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint

Q: how does chromatin move?

Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...

1/
Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)