Targeted Antimicrobial Stewardship in a Pediatric Intensive Care Unit: Using the Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Polymerase Chain Reaction (PCR) to Reduce Vancomycin Days of Therapy - PubMed This intervention in PICU patients at an academic medical center led to more rapid vancomycin discontinuation and shorter DOT. The MRSA PCR demonstrated a high NPV, supporting its use as an antimicrobial...

Targeted Antimicrobial Stewardship in a Pediatric Intensive Care Unit: Using the Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Polymerase Chain Reaction (PCR) to Reduce Vancomycin Days of Therapy

Linezolid in addition to standard antibiotic treatment for Staphylococcus aureus bacteraemia: study protocol for a randomised, placebo-controlled trial - PubMed NCT06958835.

Linezolid in addition to standard antibiotic treatment for Staphylococcus aureus bacteraemia: study protocol for a randomised, placebo-controlled trial

Living Cell-Metal Cyborg Microalgae for Treating MRSA Infection - PubMed Metal-ion-based antibacterial agents are promising against antibiotic-resistant bacteria like MRSA, but their reactive oxygen species (ROS)-dependent bactericidal activity is greatly hampered by the infection-related...

Living Cell-Metal Cyborg Microalgae for Treating MRSA Infection

Never Too Old for Arthroscopic Surgery: Woman with Low Virulence Pathogenic Shoulder Osteomyelitis - A Case Report - PubMed The incidence of advanced osteomyelitis following arthroscopic shoulder surgery is rare, with few documented cases. As the need for shoulder interventions in elderly populations increases, managing these...

Never Too Old for Arthroscopic Surgery: Woman with Low Virulence Pathogenic Shoulder Osteomyelitis - A Case Report

Design and synthesis of novel antibacterial hybrids combining quinoline and thiazole moieties - PubMed Quinoline-thiazole hybrids exhibited potent antibacterial and antibiofilm activities, with favorable drug-like properties, positioning them as promising candidates for the treatment of multidrug-resistant...

Design and synthesis of novel antibacterial hybrids combining quinoline and thiazole moieties

Molar Incisor Hypomineralization and Morphological Defects Following Pediatric Septicemia: A Case Report - PubMed Early-life septicemia during critical periods of odontogenesis may contribute to distinctive enamel and morphological defects. Awareness of these presentations can support earlier identification, closer...

Molar Incisor Hypomineralization and Morphological Defects Following Pediatric Septicemia: A Case Report

RPA Combined With CRISPR/Cas12a for Rapid and Ultrasensitive Detection Dual-Gene of Methicillin-Resistant Staphylococcus aureus (MRSA) - PubMed The increasing issue of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) necessitates rapid and reliable diagnostic methods. While existing RPA-CRISPR/Cas12a platforms have demonstrated...

RPA Combined With CRISPR/Cas12a for Rapid and Ultrasensitive Detection Dual-Gene of Methicillin-Resistant Staphylococcus aureus (MRSA)

Pharmacokinetics of Dalbavancin in Complicated Staphylococcus aureus Bacteremia: A Secondary Analysis of the DOTS Randomized Clinical Trial - PubMed Clinical Trials.gov Identifier: NCT04775953.

Pharmacokinetics of Dalbavancin in Complicated Staphylococcus aureus Bacteremia: A Secondary Analysis of the DOTS Randomized Clinical Trial

Genome-wide discovery and functional insights into novel sRNAs involved in responses to bioactive compounds in the emerging pathogen Staphylococcus haemolyticus - PubMed This study provides the first integrated framework for sRNA-mediated regulation in S. haemolyticus and shows that several newly identified sRNAs respond dynamically to biologically active compounds. These...

Genome-wide discovery and functional insights into novel sRNAs involved in responses to bioactive compounds in the emerging pathogen Staphylococcus haemolyticus

Comprehensive analysis of antimicrobial resistance and virulence determinants in clinical methicillin-resistant Staphylococcus aureus isolates collected in South Korea - PubMed Contemporary MRSA isolates in South Korea tested in this study share a conserved core virulence repertoire but display lineage-specific differences in resistance and virulence determinants. These findings...

Comprehensive analysis of antimicrobial resistance and virulence determinants in clinical methicillin-resistant Staphylococcus aureus isolates collected in South Korea

Impact of prophylactic oral azithromycin during labor on Azithromycin Resistance (AMR) in nasal Staphylococcus aureus and Streptococcus pneumoniae in women and infants in the multi-country Azithromycin Prevention in Labor Use Study (A-PLUS) - PubMed There was an increase in prevalence of azithromycin resistance (or reduction in azithromycin susceptibility) in commensal nasal S. aureus between day 7, 6 weeks and 3 months in women exposed to azithromycin...

Impact of prophylactic oral azithromycin during labor on Azithromycin Resistance (AMR) in nasal Staphylococcus aureus and Streptococcus pneumoniae in women and infants in the multi-country Azithromycin Prevention in Labor Use Study (A-PLUS)

Incidence of Acute Kidney Injury With the Use of Nafcillin Versus Oxacillin - PubMed In this study, nafcillin was associated with a significantly higher incidence of AKI than oxacillin.

Incidence of Acute Kidney Injury With the Use of Nafcillin Versus Oxacillin t.co/gwQyp1J18f

Adeno-associated virus delivery of anti-alpha toxin monoclonal antibodies confers protection against Staphylococcus aureus infections - PubMed Staphylococcus aureus is a major cause of infections, ranging from mild skin conditions to severe life-threatening systemic diseases. Despite decades of effort, vaccine development has been unsuccessful,...

Adeno-associated virus delivery of anti-alpha toxin monoclonal antibodies confers protection against Staphylococcus aureus infections

Molecular Characterization of Staphylococcus aureus and Coagulase-Negative Staphylococci Isolates at a Rural Hospital in Southern Malawi - PubMed This study reveals the presence of both multidrug-resistant CoNS and S. aureus strains with diverse spa types in rural Southern Malawi and highlights a role for molecular testing in surveillance and diagnostic...

Molecular Characterization of Staphylococcus aureus and Coagulase-Negative Staphylococci Isolates at a Rural Hospital in Southern Malawi t.co/RkL9dVWUn1

The combination of mupirocin and Kayvirus broadens the decolonization effect against Staphylococcus aureus - PubMed Staphylococcus aureus strains cause a wide range of infections in humans, often with the potential for complications such as surgical site infections. The production of Panton-Valentin leukocidin (PVL)...

The combination of mupirocin and Kayvirus broadens the decolonization effect against Staphylococcus aureus

Biofilm-associated genes and their role in antibiotic resistance among clinical Staphylococcus aureus isolates - PubMed This is the first report from Baghdad demonstrating the prevalence of these biofilm-associated genes and their link to ABR, offering potential targets for future therapeutic interventions. These results...

Biofilm-associated genes and their role in antibiotic resistance among clinical Staphylococcus aureus isolates

Evaluation of β-lactam monotherapy and conventional anti-staphylococcal combination therapy for polymicrobial MSSA infections - PubMed Beta-lactam monotherapy demonstrated comparable or superior efficacy to traditional anti-staphylococcal combination regimens for polymicrobial infections with MSSA. These findings support the potential...

Evaluation of beta-lactam monotherapy and conventional anti-staphylococcal combination therapy for polymicrobial MSSA infections

Panton-Valentine Leukocidin-Encoding Methicillin-Resistant Staphylococcus aureus, the Netherlands, 2023-20241 - PubMed We describe a community outbreak of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus (MRSA) during November 2023-June 2024 in the Netherlands. We identified a massage center...

Panton-Valentine Leukocidin-Encoding Methicillin-Resistant Staphylococcus aureus, the Netherlands, 2023-20241

Parameter-Dependent Effects of Rose Bengal Photodynamic Antimicrobial Therapy on MRSA Inhibition and Corneal Cytokine Expression - PubMed Rose bengal PDAT effectively suppresses MRSA and modulates inflammatory cytokines, supporting its use in microbial keratitis.

Parameter-Dependent Effects of Rose Bengal Photodynamic Antimicrobial Therapy on MRSA Inhibition and Corneal Cytokine Expression t.co/AfFgYQBz6z

Parameter-Dependent Effects of Rose Bengal Photodynamic Antimicrobial Therapy on MRSA Inhibition and Corneal Cytokine Expression - PubMed Rose bengal PDAT effectively suppresses MRSA and modulates inflammatory cytokines, supporting its use in microbial keratitis.

Parameter-Dependent Effects of Rose Bengal Photodynamic Antimicrobial Therapy on MRSA Inhibition and Corneal Cytokine Expression

Risk Factors Associated With Methicillin-Resistant Staphylococcus aureus Infections in Patients With Diabetic Foot Ulcers in Tehran - PubMed The findings underscore the critical importance of a comprehensive understanding of patients' medical records and underlying conditions. In addition, accurate assessment of microbial prevalence and antibiotic...

Risk Factors Associated With Methicillin-Resistant Staphylococcus aureus Infections in Patients With Diabetic Foot Ulcers in Tehran

Breaking Down Barriers: CorA Effectively Targets Staphylococcal Biofilms in Vitro and in Vivo - PubMed Biofilm-associated infections caused by Staphylococcus aureus (S. aureus) remain notoriously difficult to treat due to their pronounced tolerance to most antibiotics. Here, we evaluated the antibiofilm...

Breaking Down Barriers: CorA Effectively Targets Staphylococcal Biofilms in Vitro and in Vivo

Anti-staphylococcal activity of soil-derived Penicillium citrinum extract - PubMed This study highlights Penicillium citrinum as a promising source for safe and effective antimicrobial agents, particularly as an adjunct to antibiotics against resistant staphylococcal infections.

Anti-staphylococcal activity of soil-derived Penicillium citrinum extract

Community-Acquired Methicillin-Resistant Staphylococcus Aureus Pneumonia Complicated by Intracranial Diffuse Thrombotic Microangiopathy - PubMed This case highlights the severity of CA-MRSA pneumonia and its potential for intracranial microvascular complications, emphasizing the importance of brain MRI in septic patients with neurological impairment...

Community-Acquired Methicillin-Resistant Staphylococcus Aureus Pneumonia Complicated by Intracranial Diffuse Thrombotic Microangiopathy

From Virulence to Therapy: T6SS-Derived Antimicrobial Peptides A7 Combats APEC and MRSA Infections - PubMed The increasing prevalence of multidrug-resistant (MDR) pathogens, particularly avian pathogenic <i>Escherichia coli</i> (APEC) and methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), poses a severe...

From Virulence to Therapy: T6SS-Derived Antimicrobial Peptides A7 Combats APEC and MRSA Infections t.co/5VAklwO4qX

Hospital-Onset Bloodstream Infections: Progressive Shift from Methicillin-Resistant Staphylococcus aureus to Methicillin-Susceptible Staphylococcus aureus over 11 Years - PubMed <span><b>Background</b>: <i>Staphylococcus aureus</i> bloodstream infections cause substantial hospital mortality (20-50%). Surveillance programs primarily focus on methicillin-resistant <i>S. aureus</i>...

Hospital-Onset Bloodstream Infections: Progressive Shift from Methicillin-Resistant Staphylococcus aureus to Methicillin-Susceptible Staphylococcus aureus over 11 Years

Integrative Multi-Omics Analysis Identifies FTO as a Genetic and Epigenetic Link Between Metabolic Susceptibility and Staphylococcus aureus-Induced Airway Remodeling in Chronic Rhinosinusitis - PubMed This study identifies fat mass and obesity-associated protein (FTO) as a pivotal link between metabolic predisposition and pathogenesis associated with Staphylococcus aureus in chronic rhinosinusitis...

Integrative Multi-Omics Analysis Identifies FTO as a Genetic and Epigenetic Link Between Metabolic Susceptibility and Staphylococcus aureus-Induced Airway Remodeling in Chronic Rhinosinusitis

Synergistic Low-Intensity Pulsed Ultrasound-Activated Vancomycin-Loaded Microbubbles for MRSA Biofilm Eradication and Bone Regeneration in Periprosthetic Joint Infection - PubMed Periprosthetic joint infection (PJI), sustained by antibiotic-tolerant biofilms, hinders infection control and impairs bone healing. To address this, we developed a dual-action strategy combining low-intensity...

Synergistic Low-Intensity Pulsed Ultrasound-Activated Vancomycin-Loaded Microbubbles for MRSA Biofilm Eradication and Bone Regeneration in Periprosthetic Joint Infection t.co/2zEtLtqDSf

Integration of Pharmacists' Knowledge into a Predictive Model for Teicoplanin Dose Planning - PubMed Teicoplanin is an important antibiotic for methicillin-resistant Staphylococcus aureus infections. To enhance its clinical effectiveness while preventing adverse effects, therapeutic drug monitoring (TDM)...

Integration of Pharmacists' Knowledge into a Predictive Model for Teicoplanin Dose Planning

Discovery of an N,N'-diarylurea with potent activity against multidrug-resistant Staphylococcus aureus via perturbation of membrane homeostasis - PubMed The global prevalence of multidrug-resistant (MDR) Staphylococcus aureus highlights the urgent need for the development of new therapeutic strategies. Recent studies have revealed that selected N,N'-diarylurea...

Discovery of an N,N'-diarylurea with potent activity against multidrug-resistant Staphylococcus aureus via perturbation of membrane homeostasis t.co/FDgHnwoMK7