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Hierarchical organization of mechano-nociceptive pathways revealed by activity labeling Noxious mechanical stimuli give rise to distinct percepts, from sharp cutaneous pain to diffuse visceral discomfort, yet the nociceptor ensembles that underlie these differences remain poorly defined....

Not all pain is created equal: stepping on a nail feels different from a stomachache. We know there are many nociceptor types, but a key question remains: how is mechanical pain encoded across the body by those sensory neurons? Our new work helps answer this. 1/8
www.biorxiv.org/content/10.6...

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It will be turbulent in the next worldwide sodium channel seminar: @antoniospantazis.bsky.social will explain why "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant" Tuesday April 29th. Visit www.sodiumchannelseminars.org for link and infos. #sodiumchannel

Thank you, Ted!

Characterizing what human sensory nerves can sense Researchers analyzed gene activity in different human sensory nerve cells to predict which would respond to stimuli such as heat, cold, and pressure

Nice writeup on our latest work by NIH Research Matters: Characterizing What Human Sensory Nerves Can Sense! www.nih.gov/news-events/...