JAMA Internal Medicine editorial titled, "Statins for Primary Prevention—The Gap Between Guidelines and Patient Preferences" by Ilana B. Richman, Anna Hung, and Timothy S. Anderson. Published online February 16, 2026.

💬 Editorial: Statin guidelines and patient preferences for #ASCVD prevention often misalign, supporting the need for clearer risk communication and shared decision-making in clinical practice.

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Scatterplot: Urinary Incontinence (UI) diagnoses before & during a screening program. X-axis: Time since program initiation. Y-axis: Estimated UI diagnoses per 100 encounters. Shows data points & trend lines for 'Before' & 'During' phases.

Automated #UrinaryIncontinence screening and education in primary care increased rates of new diagnoses and referrals for pelvic floor therapy and specialty care among women, without affecting medication prescriptions. ja.ma/48tBhgP

Table 1. Claims Processing Regulatory Ecosystem^a outlines stages (initial claim review, determination, internal/external appeal review/determination, postexternal appeal oversight), regulatory context, and process descriptions.

In New York State, 46.7% of external health insurance appeals were overturned from 2019 to 2025, with highest rates for home health care and managed long-term care, supporting targeted regulatory review of denial practices. ja.ma/4cilR1a

Bar graph: Adjusted Shares of Turnover by Burnout Status. Turnover (%) is charted for 'Overall', 'Leave practice', and 'Move practice'. In all cases, the 'Burned out' share is higher than 'Not burned out'.

A national analysis linking US board-certified family physician survey responses with Medicare data found that self-reported #burnout was associated with significantly higher rates of physician turnover, including both changing practices & leaving practice.
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High-Risk Prescriptions Among Older Adults Discharged from the ED This cross-sectional study identifies the prescribing rate and most commonly prescribed classes of potentially inappropriate medications for older patients at emergency department discharge.

Among older adults discharged from emergency departments, 6.5% received high-risk medications flagged by GEMS-Rx, most commonly skeletal muscle relaxants and first-generation antihistamines. ja.ma/4maG8J3

ECG graph showing heart activity with labels I, II, III, aVR, aVL, aVF, V1-V6. Bottom section displays timing intervals: A-V values (164, 128, 113, 166, 129, 112, 164) and includes text@1 through text@11, indicating AV 4:3.

📃 This case report describes a woman in her 30s with a 10-year history of systemic lupus erythematosus presented with fever, chest tightness, oliguria, and lower extremity edema.

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Two bar charts compare the intervention vs. control groups for clinically significant residual gastric volume. Chart A: Intention-to-treat analysis, Chart B: Per-protocol analysis. Both show higher volume in the intervention group.

Continuing #GLP1 or GIP agonists before upper endoscopy increased the risk of clinically significant residual gastric volume, with no additional aspiration events.

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Oral Semaglutide and Heart Failure Outcomes in Persons With Type 2 Diabetes This secondary analysis of a randomized clinical trial evaluates the effect of oral semaglutide on heart failure events, major adverse cardiovascular events, and safety among participants with or without heart failure at baseline.

In adults with type 2 #Diabetes and heart failure (HF), oral semaglutide reduced risk of composite HF outcomes with no increase in adverse events compared to placebo. ja.ma/4vbMa08

JAMA Internal Medicine presents 'Pitfalls to Procalcitonin—Elevation in a Postvaccine Fever' by Virginia H. Sun, MD@1, Esdras O. Rodriguez, MD@1, Clement D. Lee, MD. Published online: April 13, 2026. doi: 10.1001/jamainternmed.2026.0673

📃 This case report describes a patient receiving peritoneal dialysis who presented to the emergency department with a fever and elevated procalcitonin levels the day after receiving a COVID-19 vaccine.

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Reducing Potentially Inappropriate Medication Use for Older Adults in the Emergency Department Adverse drug events in older adults are pervasive, often harmful, and potentially preventable. There are many reasons for adverse drug events in older adults, including multiple medications, pharmacodynamic changes, pharmacokinetic changes, and age-related issues in various organ systems. The...

💬 Editorial: ED-based decision support and pharmacist-led interventions can reduce discharge prescriptions for potentially inappropriate Geriatric Emergency Medication Safety Recommendations (GEMS-Rx) medications among older adults. ja.ma/3OgCZuS

JAMA Internal Medicine presents 'RCT: Palliative Care Intervention for Patients With End-Stage Liver Disease.' It shows population: 660 male, 275 female, intervention: 516 consultative and 419 hepatologist-led PC, and findings about QoL improvement.

For US patients with end-stage #LiverDisease, palliative care delivered by trained hepatologists was noninferior to specialist care for 3-month quality of life and improved patient satisfaction, supporting both care models for early intervention.

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Electrocardiogram at Presentation: The 12-lead electrocardiogram shows sinus rhythm with nonspecific ST-segment changes. Subtle ST depressions in leads V@1 through V@3 are suggestive of posterior myocardial infarction; no overt ST elevation.

A healthy woman in her early 60s presented with 4 hours of substernal chest pain and diaphoresis. The initial electrocardiogram was read as showing no diagnostic abnormalities, and she was referred for outpatient evaluation.

📄Read the full case report:
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JAMA Internal Medicine cover: Editorial "Less Is More," Deprescribing Proton Pump Inhibitors and the Challenge of Legacy Medications by Timothy S. Anderson, MD, MAS1,2,3. Published online April 13, 2026. doi: 10.1001/jamainternmed.2026.0594

💬 Editorial: Deprescribing interventions combining prescriber education and patient materials led to greater reductions in long-term proton pump inhibitor use, without increased reflux symptoms, compared to prescriber-only or usual care.
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JAMA Internal Medicine presents an RCT on deprescribing intervention for proton pump inhibitor use. Population: 14902 males, 19507 females. Intervention: 34409 patients analyzed. Findings show patient- and GP-facing deprescribing doubled PPI reduction.

A patient- and general practitioner–facing intervention led to greater reductions in inappropriate long-term proton pump inhibitor use among primary care patients than practitioner-only or usual care, without affecting GERD symptom scores. ja.ma/4vyZnR9

Inpatient Framework for Rapid Methadone Titration (RMT) figure, with patient selection criteria, dosing protocol, monitoring, and discharge planning steps. Text includes 'Consider RMT if: daily fentanyl use' and 'Assess interest in posthospital methadone continuation'.

This Teachable Moment describes how traditional titration protocols for patients with #fentanyl use disorder may be inadequate for patients with frequent, high-dose, or high-potency #opioid use.

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JAMA Internal Medicine patient page titled "Where Can I Find Reliable Information About Vaccines?" lists information sources, descriptions, and examples such as World Health Organization and the American Academy of Pediatrics.

This JAMA Internal Medicine Patient Page describes sources of information about #vaccination and how to know which sources are trustworthy.

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Treating Chronic HCV Infections in Jail Is Feasible and Cost-Effective With the advent of the direct-acting antivirals to treat hepatitis C virus (HCV), there has been hope of eliminating chronic HCV infections. The World Health Organization has targeted global eliminati...

New in @jamainternalmed.com - Treating HCV in jails & prisons is feasible (though not w/o challenges) and a cost-effective to reduce morbidity/mortality and subsequent healthcare costs; yet ?'s remain on how we fund these programs. @seicheyale.bsky.social
jamanetwork.com/journals/jam...

New @jamainternalmed.com study led by CP3’s @timandersonmd.bsky.social: a virtual, team-based program (pharmacist tapering + mindfulness CBT) helped older adults reduce benzodiazepines by ~60%. Feasible, acceptable, and ready for multi-site testing.

link.springer.com/article/10.1...

@jamainternalmed.com editorial highlights early impact of 2024 IRA Part D reforms: cost-related💊nonadherence fell among Medicare beneficiaries but rose among commercially insured adults. Gains are promising, but affordability challenges remain.

jamanetwork.com/journals/jam...

💡🏥 "Wait Time Modifications for Black Transplant Candidates Affected by Race-Based Kidney Function Estimation" | @jamainternalmed.com

Our new study quantifies impacts of an unprecedented national policy to remedy harms of a race-based clinical algorithm.
doi.org/10.1001/jama...

Cost-Related Medication Nonadherence After the Inflation Reduction Act This difference-in-differences analysis evaluates the association of the Inflation Reduction Act’s 2024 prescription drug provisions with cost-related medication nonadherence as well as health care–re...

Millions of Americans skip medications because they can't afford them. Did the Inflation Reduction Act help?

Our new @jamainternalmed.com study finds the IRA's 2024 drug provisions ⬇️⬇️ cost-related medication nonadherence—especially among those w/ multiple conditions
jamanetwork.com/journals/jam...

JAMA Internal Medicine: RCT: Produce Prescription Subsidy for Patients With Diabetes. Population: 631 men, 1524 women, adults with diabetes, mean age 56. Intervention: 2177 participants randomized. Findings: No significant differences.

A produce prescription subsidy providing $80 per month did not improve glycemic control, blood pressure, body mass index, or health care use for patients with #Diabetes at risk for food insecurity.

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Table showing share of population in communities without dialysis facilities. Most disadvantaged communities have 11.7% without facilities, while most advantaged have 2.3%. Dialysis stations & facilities per 1000 residents are also detailed.

Communities with higher socioeconomic disadvantage had reduced access to dialysis facilities and fewer nearby stations, highlighting persistent inequities in US dialysis care.

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Incidental Rotator Cuff Abnormalities on Magnetic Resonance Imaging This cross-sectional study assesses the prevalence of shoulder rotator cuff abnormalities in a general Finnish population and whether diagnostic imaging should guide diagnosis or treatment of atraumatic shoulder pain.

Rotator cuff abnormalities on #MRI were found in 99% of adults aged 41–76, including 96% of asymptomatic shoulders, indicating most findings are age-related rather than disease. ja.ma/4cpiKEw

JAMA Internal Medicine: Research Letter | Women's Health, Accuracy of Self-Selection for Medication Abortion Using a Prototype Drug Facts Label. Authors: Lauren J. Ralph, et al. Published Online: April 6, 2026. doi: text@1

Most patients seeking abortion accurately self-selected eligibility for #MedicationAbortion using a prototype OTC package and drug facts label, with 88% concordance with clinician assessment.

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Bar graph: Adjusted Shares of Turnover by Burnout Status. Turnover (%) is charted for 'Overall', 'Leave practice', and 'Move practice'. In all cases, the 'Burned out' share is higher than 'Not burned out'.

A national analysis linking US board-certified family physician survey responses with Medicare data found that self-reported #burnout was associated with significantly higher rates of physician turnover, including both changing practices & leaving practice.
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Inpatient Framework for Rapid Methadone Titration (RMT) lists patient selection, dosing, monitoring, and discharge planning. It shows when to consider RMT or slower titration with factors like opioid use or QTc levels and outlines a sample methadone protocol.

This Teachable Moment describes how traditional titration protocols for patients with fentanyl use disorder may be inadequate for patients with frequent, high-dose, or high-potency opioid use.

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Two bar charts compare the intervention vs. control groups for clinically significant residual gastric volume. Chart A: Intention-to-treat analysis, Chart B: Per-protocol analysis. Both show higher volume in the intervention group.

Continuing #GLP1 or GIP agonists before upper endoscopy increased the risk of clinically significant residual gastric volume, with no additional aspiration events.

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Diagram illustrating orthostatic hypotension(OH): On standing, text@1 L of blood transfers to the lower body, causing decreased cerebral perfusion. Symptoms: lightheadedness, weakness, fatigue, visual blurring, neck pain, falls. Treatment includes medication review and increased water intake.

#OrthostaticHypotension increases fall and mortality risk in older adults.

📌 This Review aims to present important diagnostic and treatment approaches for a generalist audience to improve confidence in managing this important medical condition.

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JAMA Internal Medicine journal cover. Headline: "Insulin Copay Caps—Impacts Beyond Costs". Authors: Anna Hung, Sharon K. Inouye, Raegan W. Durant. Published online April 6, 2026. doi: 10.1001/jamainternmed.2026.0268

💬 Editorial: The $35 insulin copay cap for Medicare Part D beneficiaries reduced insulin costs and improved glycemic control among existing users, but did not increase overall insulin initiation or lower total drug spending.

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