A graph of eye velocity versus time that establishes that fish with loss of function mutations in the phox2a gene can't move their eyes when tilted.
An image showing expression of a particular gene in the motor neurons that move the eyes. Black spots show where the gene is expressed, dotted lines outline the cranial motor nucleus nIV that contains motor neurons that move the eyes up
The top shows a schematic of a fish with motor neurons marked in green and a pipette used to suction motor neurons for later analysis. The bottom left shows white dots that mark each motor neuron; the bottom right shows no white dots to indicate the motor neurons had been selectively removed for later analysis.
Our new work goes from genes to behavior to understand the molecular underpinnings of the most common childhood disorder of vision: strabismus. Led by UCSF-bound Emily Gershowitz & Kyla Hamling, plus rockstars
@denagoldblatt.bsky.social & @paigel.bsky.social
www.biorxiv.org/content/10.6...
2 weeks ago
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Who wore it better? Our new paper shows that rat OFC supports Bayesian inference of hidden states! With neural correlates of inferred state transitions at the level of single neurons and population-level latent factors. www.sciencedirect.com/science/arti...
5 months ago
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Iβm watching the World Series. Iβm taking part o the Stanford prison experiment. Iβm at the combination World Series/Stanford prison experiment
5 months ago
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After 14 innings the ballpark organist should switch to only playing in a minor key #worldseries
5 months ago
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Establishing the President's Make America Healthy Again Commission
By the authority vested in me as President by the Constitution and the laws of the United States of America, itΒ isΒ hereby ordered: Section 1.
Giving infectious disease research a break, as promised by the MAHA agenda.
Let's break down what exactly this Executive Order is *really* saying.
Fortunately, I speak fluent anti-vax grifterese & can translate.
www.whitehouse.gov/presidential...
1 year ago
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Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.
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Thank you!! And congratulations on your recent defense!
1 year ago
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Thanks! I'm definitely very lucky to be working with her (while also finishing more things up with David π€ )
1 year ago
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So excited to share our first paper from my PhD! Chasing this question was so rewarding; I hope that comes across in the writing. Thank you @denagoldblatt.bsky.social, @cbellegarda.bsky.social, Cheryl, and BaΕak for being wonderful teammates and @schoppik.bsky.social for the excellent bluetorial π€
1 year ago
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Thank you! It's been great here so far, and my standards were already high coming from my grad lab :)
1 year ago
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Beautifully written work led by an incredible former undergrad in my PhD lab! Check it out if you're curious about how sensorimotor circuits assemble π«
1 year ago
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Happy to share my 2nd PhD paper! We use CRISPR, calcium imaging & sequencing approaches to (1) overturn a decades-old model for how a balance circuit develops and (2) redefine the role of motor neurons in circuit assembly. 1/n
2 years ago
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