Behavioural setups to study social modulation of fear responses to visual stimuli

A year in review and a year preview!
2024 highlights:
1. Lab up and running @northumbriauni.bsky.social to study the 'Neural basis of social behaviour in groups', with the support of the Applied Sciences department, a
@royalsociety.org grant and the continued support of @moitalab.bsky.social

Want to do a PhD in Neuroscience? Applications are open until January 31st for the Champalimaud International Neuroscience Doctoral Programme (INDP) in beautiful Lisbon Portugal.

fchampalimaud.org/champalimaud...

Our Fellows-to-Faculty Award is accepting applications from talented early career scientists looking to transition to tenure-track positions: www.simonsfoundation.org/funding-oppo... Hear about awardee Abhilasha Joshi's experience with the program below. #science #neuroscience #autismresearch

This work just goes to show that cool discoveries can come when you least expect them! Muscle activity revealed a whole new world of physiology and behaviour while the fly is standing still – we just needed to start looking below the surface to see it. 🧊🦵💓 (7/7)

But is this pulsing just an output, or does it actually cause movement? We increased the pulsing activity artificially by optogenetically activating the motor neuron that innervates it, causing flies to break from freezing earlier, and showing that the pulsing state can be causal for movement onset.

Amazingly, the leg heart adapted its rhythm to cues of threat and safety. More deeply freezing flies showed less pulsing, and when the flies felt safer after seeing other flies start moving around them, pulsing increased. (5/7)

Pulsing of the leg heart ramped up to and preceded movement onset, implying that its beating is reflecting a state of ‘preparation’ to move. (4/7)

This activity turned out to be an accessory leg heart – the first time this has been observed in Drosophila. But the story didn’t end there, because the activity of this heart was exquisitely tuned to the behaviour of the fly. (3/7)

This scientific adventure, led by annahobbiss.bsky.social, ft. Mariana Franco, alexmeddroso.bsky.social, charlierosher.bsky.social in a fantastic collaboration with cmendeslab.bsky.social which started when we discovered a curious pulsing activity in the legs of flies while they’re freezing. 🤔

Thrilled to present our latest BioRXiv on brain/body interactions during defensive freezing behaviour! (www.biorxiv.org/content/10.1...). You might think that a frozen animal has, well, frozen muscle activity, right? Wrong! Underneath the still surface of a fly, something in the legs is beating… 🧵

Thank you! 🤩

We would love to join the pack 😁