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Posts by γδ T cell Forum

γδ T cell-stromal networks modulate matrix composition and vascularity in foreign body response - Nature Communications The foreign body response involves immune cell activation and fibrosis, understanding the connection of the two is important for the biomedical engineering field. Here the authors show in a mouse biom...

γδ T cell-stromal networks modulate matrix composition and vascularity in foreign body response

#gdTcells @natcomms.nature.com

3 days ago 0 0 0 0

CD16+ γδ T cells mediate antibody-dependent cellular cytotoxicity and associate with viral control in chronic hepatitis B virus infection

#gdTcells

6 days ago 1 0 0 0

Are you attending the upcoming @aai.org meeting in Boston (April 15-19) and presenting your work on #GDTcells? Please connect with @payalyokota.bsky.social - founder/organizer of the #GDTcellclub series - esp if you'd like to give a talk in the 2027 series or be a part of the organizing committee.

1 week ago 5 3 0 0

Are you attending the upcoming @aai.org meeting in Boston (April 15-19) and presenting your work on #GDTcells? Please connect with @payalyokota.bsky.social - founder/organizer of the #GDTcellclub series - esp if you'd like to give a talk in the 2027 series or be a part of the organizing committee.

1 week ago 5 3 0 0
An immunobiliary single-cell atlas resolves crosstalk between type 2 conventional dendritic cells and γδ T cells in cholangitis - Nature Communications Primary sclerosing cholangitis (PSC) is an autoimmune condition affecting the liver. Here, the authors generate an immunobiliary transcriptomic atlas and show that dendritic cell and γδ T cell interactions play a role in murine models of cholestatic liver injury and fibrosis.

An immunobiliary single-cell atlas resolves crosstalk between type 2 conventional dendritic cells and γδ T cells in cholangitis

#gdTcells @natcomms.nature.com

1 week ago 6 1 0 0

Cytotoxic Vδ2+ T cell subsets expand in response to malaria in human tonsil and spleen organoids

#gdTcells

1 week ago 3 0 0 0

Thank you for joining us for the webinar today and here's a link of the recording. *See* you on May 21st!

nyulangone.zoom.us/rec/share/8R...

Passcode: #GDTcellclub040926

1 week ago 1 0 0 0

Brilliant talk by Dr. Anna Bold talking about exciting clinical avenues with Vg9Vd2 cells and bispecific antibodies! #OnNOW

1 week ago 1 0 0 0
Delete an event - Android - Google Calendar Help If you don't want an event to show up anymore, you can delete or remove it from Google Calendar. Important: Calendar might mark some events as spam and move them to the trash. If you have an account

If anyone is having issues adding this event to your google calendar - please follow the link below for instructions on how to move it from the trash. Google may have flagged this even due to the large amount of traffic! support.google.com/calendar/ans...

2 weeks ago 0 0 0 0

Join us for a fantastic seminar by Dr. Anna Bold from Paracelsus Medical University at Nuremberg talk about her new approach to target tumors using a combination of ex vivo activated Vg9Vd2 T cells with antibodies. 👇

April 9, 2026 - 12p NYC time / 6p German time
nyulangone.zoom.us/j/9589051706...

2 weeks ago 4 2 0 0
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Join us for our April #GDTcellclub webinar talk with Dr. Anna Bold (Paracelsus Medical University) on

April 9, 12p EDT (NYC time) / 5p London/UK

Zoom ID: 958 9051 7066/ passcode 369081
nyulangone.zoom.us/j/9589051706...

subscribe to the calendar event here:
calendar.google.com/calendar/u/0...

2 weeks ago 3 1 1 3
JCI Insight - Dietary Indoles Influence the AHR–RORγt Axis and Mucosal Immune Homeostasis in ART-Treated SIV Infection

Dietary Indoles Influence the AHR–RORγt Axis and Mucosal Immune Homeostasis in ART-Treated SIV Infection

#gdTcells @insight.jci.org
insight.jci.org/articles/vie...

2 weeks ago 3 0 0 0
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In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development Human γδ T cells differ greatly from mouse γδ T cells. La et al. report that it is possible to generate bona fide human γδ T cells in a humanized immune system mouse model. Additionally, they show tha...

www.cell.com/cell-reports...

3 weeks ago 4 0 0 0
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Seven subsets, two fates: mouse γδ T cells in cancer immunity The importance of γδ T cells in cancer, as defenders against tumorigenesis, was established more than 2 decades ago. Since that time, research using mouse models of cancer has brought to light a nonun...

www.cell.com/trends/immun...

3 weeks ago 5 1 0 0

So great to see this out in print! Congratulations to Yue and @drshrutinaik.bsky.social team on this fantastic story! 🎉 #GDTcells

1 month ago 10 3 1 0
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Seven subsets, two fates: mouse γδ T cells in cancer immunity The importance of γδ T cells in cancer, as defenders against tumorigenesis, was established more than 2 decades ago. Since that time, research using mouse models of cancer has brought to light a nonun...

Seven subsets, two fates: mouse γδ T cells in cancer immunity: Trends in Immunology www.cell.com/trends/immun...

@coffeltlab.bsky.social
#gdTcells

3 weeks ago 12 2 0 0
KRT17 promotes triple negative breast cancer through activation of Wnt signaling and γδ T-cells recruitment - Communications Biology Black American patients with TNBC show elevated KRT17 versus White Americans, linked to poor metastasis free survival. KRT17 activates Wnt signalling, CSCs, and γδ T-cell recruitment, promoting metast...

KRT17 promotes triple negative breast cancer through activation of Wnt signaling and γδ T-cells recruitment

#gdTcells @commsbio.nature.com

3 weeks ago 3 0 0 0
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@biorxivpreprint.bsky.social Innate immune sensing by γδ T clls of cell traversal by Plasmodium sporozoites drives protective T cell responses
www.biorxiv.org/content/10.6...

4 weeks ago 4 2 0 0
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4 weeks ago 0 0 0 0

Thank you for joining us on March 19 #GDTCellclub webinars with Drs. Judith Wienke and Monika Wolkers on pediatric neuroblastoma.

For recorded talks:
nyulangone.zoom.us/rec/share/wL...
Passcode: #GDTcellclubMarch19

👉payalyokota.com/gamma-delta-t-cell-webin... to stay informed!

1 month ago 0 0 0 1

Our second speaker, Dr. Monika Wolkers, with more insights about the specific phenotypes of GDTs in the neuroblastoma TME

1 month ago 0 0 0 0

Please join us for the March #GDTcellclub webinar today w/ our first speaker Dr. Judith Wienke talking GDTs in neuroblastoma

1 month ago 1 0 1 0
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Dual faces of γδ T cells in trypanosomatid infections In this review, we tell the story of how two related parasites that belong to the same genus, Trypanosoma brucei and Trypanosoma cruzi, cause very dis…

Dual faces of γδ T cells in trypanosomatid infections

#gdTcells @cp-trendsparasitol.bsky.social

1 month ago 1 2 0 0
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In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development Human γδ T cells differ greatly from mouse γδ T cells. La et al. report that it is possible to generate bona fide human γδ T cells in a humanized immune system mouse model. Additionally, they show tha...

In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development

#gdTcells @cp-cellreports.bsky.social

1 month ago 3 2 0 0

γδ T cell, αβ T cell and B cell

2 months ago 5 1 0 0
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Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model In lung cancer, airway macrophages are modulated by an unconventional T cell subset, relevant to care for pulmonary comorbidities.

Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model

#gdTcells @coffeltlab.bsky.social

1 month ago 3 2 0 0
GFI1 as a novel regulator of γδ T cell development and the IL-17/IFNγ lineage commitment GFI1 is a DNA-binding zinc finger transcription factor regulating the commitment of hematopoietic precursors to myeloid and lymphoid lineages. Here we report that GFI1 is expressed in γδ T cells and restricts the cellularity of RORγt+Vγ6+ γδT cells that produce high levels of IL-17A, while promoting the expansion of Vγ1+ and Vγ4+ γδT cells. Absence of GFI1 results in a pronounced bias toward the production of γδT17 cells, commencing post-birth. Additionally, we observe an expansion of RORγt+/MAF+ cells within the thymic DN1e population of GFI1-deficient mice. The DN1e population, along with other DN subsets in GFI1 knock-out (KO) mice, exhibits a distinctive γδT17 cell-specific transcriptomic profile. Specifically, DN1, DN3, and γδ T cells lacking GFI1 show upregulation of the B-ZIP transcription factor MAF, which regulates genes critical for γδT cells, such as Il17a, Il22, and Blk that are all induced in Gfi1 deficient cells. The Maf gene is occupied by GFI1 in DN pre-T cells at cognate binding sites in its promoter region, suggesting that GFI1 acts as a direct repressor of Maf. We conclude that GFI1 functions as a novel regulator of Vγ6+ γδT17 precursor cells restricting their peripheral expansion by acting upstream of a MAF dependent regulatory network. ### Competing Interest Statement The authors have declared no competing interest. Canadian Institutes of Health Research, https://ror.org/01gavpb45, FDN - 148372

www.biorxiv.org/content/10.6...

1 month ago 2 0 0 0
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γδ T Cells for Cancer Immunotherapy: Unconventional Players Take the Spotlight The success of cancer immunotherapy depends on the mobilization of leukocytes with the capacity to eliminate tumor cells. γδ T cells represent a lymphocyte lineage with strong cytotoxic potential and ...

γδ T Cells for Cancer Immunotherapy: Unconventional Players Take the Spotlight

#gdTcells @bsilvasantos.bsky.social

1 month ago 1 1 0 0
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Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection TCRγδ+ intraepithelial lymphocytes (γδIELs) are crucial for maintaining intestinal homeostasis, yet their functional regulation remains incompletely u…

Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection

#gdTcells @cp-immunity.bsky.social

1 month ago 4 2 0 0
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Peripheral immune-inducer dendritic cells drive early-life allergic inflammation - Nature Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation

#gdTcells @nature.com

1 month ago 2 0 0 1