Really enjoyed your talk! Sorry you couldn’t be here in person.

Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.

🧪 Really cool new #circadian paper looking at the role of the liver clock in inter-organ crosstalk with muscle during Cachexia "Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia": Cell www.cell.com/cell/fulltex...

Muscle samples from patients with pancreatic cancer inform on muscle wasting—

@andyjudge24.bsky.social and team reveal that complement activation contributes to skeletal muscle pathology in PDAC cachexia.

Full report: buff.ly/ZKft1gx

Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia Ducharme et al. investigate the impact and crosstalk between cancer and FoxP1 on the skeletal-muscle circadian transcriptome that mediates time-of-day-dependent biological functions. They reveal cancer/disease-specific functions of FoxP1 in the disruption and reprograming of the skeletal-muscle circadian transcriptome, which may contribute to cancer-induced muscle loss.

Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia

Cancer induced FoxP1 expression in muscle reprograms muscle clock output. Why does this matter? By co-opting normal clock output, FoxP1 is disrupting homeostatic pathways important for muscle health. We posit that this clock disruption could be a factor contributing to cachectic outcomes.

Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia Ducharme et al. investigate the impact and crosstalk between cancer and FoxP1 on the skeletal-muscle circadian transcriptome that mediates time-of-day-dependent biological functions. They reveal cance...

Its taken a few years but finally had science fun collaborating with @andyjudge24.bsky.social, @sarahjudge.bsky.social and the talented postdoc @jbducharme.bsky.social with support from Miguel Gutierrez-Monreal. Cancer and the muscle clock. 1/ www.cell.com/cell-reports...

Come tune in next week to the CCS Trainee Talks to hear some of our recent work in the Judge Lab! Zoom registration link is on the CCS website.

A great opening session of speakers on the topic of cancer cachexia at the Advances in Skeletal Muscle Biology (ASMB) conference at UFMyology, which included the CMR's Prof Paul Gregorevic

Ablation of satellite cell‐specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile‐induced injury Ablation of SC-Bmal1 lowered force production and altered the magnitude of muscle damage/repair and SC myogenic progression following eccentric contractile injury.

Ablation of satellite cell-specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile-induced injury
faseb.onlinelibrary.wiley.com/doi/10.1096/...

Thank you Andy!

So proud of all the lab for their hard work, some of which they shared at #SCWDConference. Dr. Ducharme even brought home the Young Investigator Award 🙌🏼 Congrats Jeremy

The 8th Cancer Cachexia Conference will be hosted in Turin Italy, Sept 25-27, 2025