Screening and validation of key metastasis-associated genes in pancreatic cancer using a multi-omics and machine learning approach Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies worldwide, characterized by early metastasis and challenges in early di…

Screening and validation of key metastasis-associated genes in #PancreaticCancer using a multi-omics and machine learning approach www.sciencedirect.com/science/arti... 🧬🖥️🧪

Role of SCAP in regulation of pancreatic homeostasis, pancreatitis, and tumorigenesis - Oncogene Oncogene - Role of SCAP in regulation of pancreatic homeostasis, pancreatitis, and tumorigenesis

Role of SCAP in regulation of pancreatic homeostasis, pancreatitis, and tumorigenesis www.nature.com/articles/s41... #PancreaticCancer 🧪

Elraglusib and chemotherapy in metastatic pancreatic ductal adenocarcinoma: a randomized controlled phase 2 trial - Nature Medicine In this phase 2 trial, combination treatment with elraglusib, a cell-permeable ATP-competitive inhibitor of glycogen synthase kinase-3β, and gemcitabine plus nab-paclitaxel (GnP), in patients with pre...

Elraglusib and chemotherapy in metastatic pancreatic ductal adenocarcinoma: a randomized controlled phase 2 trial www.nature.com/articles/s41... #PancreaticCancer 🧪

Mutant KRAS promotes NF-kB driven CCL20 chemokine expression in pancreatic ductal adenocarcinoma www.biorxiv.org/content/10.6... #PancreaticCancer 🧪

Metabolic Salvage and Acyl-chain Remodeling Support Glycosphingolipid Synthesis with the PDAC Tumor Microenvironment www.biorxiv.org/content/10.6... #PancreaticCancer 🧪

kermit the frog is typing on a typewriter . ALT: kermit the frog is typing on a typewriter .

Writting mode...

Targeting HAS2 to enhance anti-tumor immunity in #PancreaticCancer via PD-L1 regulation 🧪 idp.nature.com/authorize?re...

Integrating Radiomics and Computational Pathology to Predict Early Recurrence of Pancreatic Ductal Adenocarcinoma and Uncover Its Biological Basis in Tumor Microenvironment Accurate prediction of early recurrence in pancreatic ductal adenocarcinoma is vital for optimizing treatment. A novel, integrated radiomics-pathology machine learning model successfully forecasts re...

Integrating Radiomics and Computational Pathology to Predict Early Recurrence of Pancreatic Ductal Adenocarcinoma and Uncover Its Biological Basis in Tumor Microenvironment advanced.onlinelibrary.wiley.com/doi/10.1002/... #PancreaticCancer 🧪

Exosomal miR-92a-3p promotes #PancreaticCancer cells' extravasation by inducing vascular permeability through inhibition of DAB2IP idp.nature.com/authorize?re... 🧪

Transcriptomic, Genomic, and Clinical Characterization of Morphological Classes in Localized and Metastatic #PancreaticCancer 🧪 www.biorxiv.org/content/10.6...

Ketogenic supplementation enhances KRASG12D inhibitor efficacy in pancreatic ductal adenocarcinoma

Ketogenic supplementation enhances KRASG12D inhibitor efficacy in pancreatic ductal adenocarcinoma #PancreaticCancer 🧪 www.sciencedirect.com/science/arti...

CA19-9 promotes liver metastasis of #PancreaticCancer through E-selectin mediated extravasation 🧪 www.biorxiv.org/content/10.6...

Hereditary chronic pancreatitis induced plasticity cooperates with mutant Kras in early pancreatic carcinogenesis gut.bmj.com/cgi/content/... 🧪 #PancreaticCancer

NFATC2 in pancreatic cancer-associated fibroblasts predicts treatment response and facilitates ERBB-targeted therapies www.biorxiv.org/content/10.6... 🧪 #PancreaticCacner

Prostaglandin E2-driven dedifferentiation of Schwann cells leads to perineural invasion in pancreatic ductal adenocarcinoma - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Prostaglandin E2-driven dedifferentiation of Schwann cells leads to perineural invasion in pancreatic ductal adenocarcinoma

Prostaglandin E2-driven dedifferentiation of Schwann cells leads to perineural invasion in pancreatic ductal adenocarcinoma idp.nature.com/authorize?re... #PancreaticCancer 🧪

Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense stromal fibrosis that promotes immune exclusion and treatment resistance, yet the up…

Targeting PI3Kδ suppresses #PancreaticCancer by dual disruption of fibrosis and immune evasion 🧪 www.sciencedirect.com/science/arti...

Targeting tumor-intrinsic CDK1/Cyclin B1 complex improves responses to immunotherapy in pancreatic cancer Immunotherapies, especially immune checkpoint blockade, has achieved considerable success in multiple cancers; however, patients with “cold tumors”, i…

Targeting tumor-intrinsic CDK1/Cyclin B1 complex improves responses to immunotherapy in #PancreaticCancer 🧪 www.sciencedirect.com/science/arti...

Filgotinib inhibits METTL3-mediated m6A of EIF3A by targeting ERG-TBP to suppress PDAC progression JAK-STAT3-independently 🧪 #PancreaticCancer www.nature.com/articles/s41...

ALDH1L2 regulates reactive oxygen species and acinar-to-ductal metaplasia in the pancreas - Nature Metabolism In the early stages of pancreatic ductal adenocarcinoma (PDAC) development, loss of ALDH1L2 expression elevates reactive oxygen species levels, driving accelerated acinar-to-ductal metaplasia. Decreas...

ALDH1L2 regulates reactive oxygen species and acinar-to-ductal metaplasia in the pancreas 🧪 #PancreaticCacner idp.nature.com/authorize?re...

NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions - Nature Metabolism Temporal profiling of central carbon metabolism during KrasG12D-driven acinar-to-ductal metaplasia reveals that disruptions in NADPH-producing enzymes accelerate the formation of pancreatic precancero...

NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions 🧪 #PancreaticCancer idp.nature.com/authorize?re...

Quemliclustat and chemotherapy with or without zimberelimab in metastatic pancreatic adenocarcinoma: a randomized phase 1 trial - Nature Medicine In a phase 1b trial, patients with treatment-naive metastatic pancreatic adenocarcinoma received the CD73 inhibitor quemliclustat plus gemcitabine and nabpaclitaxel with or without the anti-PD1 antibo...

Quemliclustat and chemotherapy with or without zimberelimab in metastatic pancreatic adenocarcinoma: a randomized phase 1 trial #PancreaticCancer 🧪 www.nature.com/articles/s41...

DHHC7 palmitoylates KRAS4A and promotes mutant KRAS-driven #PancreaticCancer 🧪 www.biorxiv.org/content/10.6...

Bulk RNA sequencing deconvolution of pancreatic ductal adenocarcinoma identifies cancer-associated fibroblast subsets associated with survival and tumor microenvironment composition 🧬🖥️ #PancreaticCancer www.biorxiv.org/content/10.6...

ASEICA organiza talleres de reuniones efectivas y colaboración en equipos de investigación para Predocs, Postdocs y Jóvenes IPs - Aseica ASEICA-Joven ofrecerá una serie de talleres dirigidos a predocs, postdocs y jóvenes investigadores principales que tratarán aspectos relacionados con la planificación y el trabajo en equipo. ASEICA vu...

‼️TALLERES DE REUNIONES EFECTIVAS Y COLABORACIÓN EN EQUIPOS DE INVESTIGACIÓN

👉Para Predocs, Postdocs y Jóvenes IPs

📆11/12/14 MAYO
🕦10 a 12h
✍️ antes del 19 de abril
✅Aforo limitado

www.aseica.es/aseica-organ...

Upcoming webinar today at 14.00 CET time! 💥

"Liquid Biopsy Diagnostics for Perioperative Care in PDAC - Insights from an East German Academic Surgery Department" 🧪 🧬

Join us and discover the value of liquid biopsy at the frontier of research in pancreatic cancer! 💫

transpan.eu/transpan-web...

A Deep Learning Pathomic Signature Predicts Survival and Recurrence in Pancreatic Ductal Adenocarcinoma Independent of CA19-9 The stratification of pancreatic ductal adenocarcinoma (PDAC) remains challenging due to the limitations of current staging systems and the ineffectiv…

A Deep Learning Pathomic Signature Predicts Survival and Recurrence in Pancreatic Ductal Adenocarcinoma Independent of CA19-9 🧪 #PancreatiCancer www.sciencedirect.com/science/arti...

Thanks to all students and colleagues for the interest. This is how science advances. 🚀

Today we had an incredible seminar with @rcastellsg.bsky.social on how AI is redesigning proteins from scratch. 🧬🤖 We're no longer just predicting structures, we're creating them to treat cancer. A vital session for our researchers and biomedicine students.
Thanks, Roger @cniostopcancer.bsky.social

Rationale for multi-epitope TGFβ vaccination in pancreatic cancer: evidence from immunologic and clinical correlates - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Rationale for multi-epitope TGFβ vaccination in pancreatic cancer: evidence from immunologic and clinical correlates

Rationale for multi-epitope TGFβ vaccination in #PancreaticCancer: evidence from immunologic and clinical correlates idp.nature.com/authorize?re... 🧪

Cross-species single-cell atlases chart progression, therapy-driven remodelling and immune evasion in #PancreaticCancer 🧪 www.biorxiv.org/content/10.6...