Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze!

www.science.org/doi/10.1126/...

Identification of a plasma membrane complex that interacts with phyB to regulate ROS production Phytochorme B interacts with a plasma membrane complex containing respiratory burst oxidase homolog D to regulate reactive oxygen species production during

Identification of a plasma membrane complex that interacts with phyB to regulate ROS production

academic.oup.com/plphys/advan...

Extracellular ATP signaling regulates systemic calcium signaling in the response of Arabidopsis seedlings to local wounding Abstract. The response of plants to local environmental stimuli can be activated in the tissues or organs that are directly challenged, as well as systemic

Extracellular ATP signaling regulates systemic calcium signaling in the response of Arabidopsis seedlings to local wounding

academic.oup.com/jxb/advance-...

PsAvh109 suppresses SA-triggered immunity by mimicking TPL function to disrupt mediator complex assembly - Nature Communications Tan et al. demonstrate that a P. sojae effector mimics a plant transcriptional repressor to block immune gene activation. Induced by host salicylic acid, PsAvh109 targets the Mediator complex, thereby...

PsAvh109 suppresses SA-triggered immunity by mimicking TPL function to disrupt mediator complex assembly

www.nature.com/articles/s41...

Pathogen-inducible expression of autoactive NLRs confers multi-pathogen resistance in tomato

www.biorxiv.org/content/10.1...

Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation

www.science.org/doi/10.1126/...

Our new experimental evolution study across 30+ locations using the plant Arabidopsis thaliana —— we direct "see" adaptation and extinction to different climates at the genetic as it happens!

Read it in Science
dx.doi.org/10.1126/scie...

@ucberkeleyofficial.bsky.social
@hhmi-science.bsky.social

Signatures of the coevolutionary arms race in response to effector-triggered immunity in the Pseudomonas syringae HopZ type III effector family Host-pathogen interactions are coevolutionary battles often described as arms races, requiring evolutionary change in both partners, functional conseq…

Signatures of the coevolutionary arms race in response to effector-triggered immunity in the Pseudomonas syringae HopZ type III effector family

www.sciencedirect.com/science/arti...

Plant NLRs are getting into higher‐order architectures Plant immune receptors known as nucleotide-binding leucine-rich repeats (NLRs) dynamically assemble into diverse higher-order structures, such as multimeric complexes, filaments, and biomolecular con...

Plant NLRs are getting into higher-order architectures

onlinelibrary.wiley.com/doi/10.1111/...

SIB1‐SEC23A undergo ER to chloroplast relocalization to mediate immunity in Arabidopsis thaliana SEC23A mediates membrane trafficking between the endoplasmic reticulum (ER) and Golgi apparatus and interacts with the immunity protein SIGMA FACTOR-BINDING PROTEIN1 in Arabidopsis. Under stress, bot...

SIB1-SEC23A undergo ER to chloroplast relocalization to mediate immunity in Arabidopsis thaliana

onlinelibrary.wiley.com/doi/10.1111/...

Higher optimal temperature for vegetation transpiration than for photosynthesis - Nature Plants Global observations show that ecosystems sustain transpiration at temperatures above those that maximize photosynthesis. This thermal gap reveals that carbon uptake declines before water loss under cl...

Higher optimal temperature for vegetation transpiration than for photosynthesis

www.nature.com/articles/s41...

Molecular basis for methylation-sensitive editing by Cas9 - Nature ThermoCas9, a genome-editing enzyme that is sensitive to the DNA methylation status of the target locus, is characterized and shows promise for targeting hypomethylated DNA regions in cancer cells.

Molecular basis for methylation-sensitive editing by Cas9

www.nature.com/articles/s41...

N-hydroxypipecolic acid acts as a mobile signal for systemic acquired resistance

N-hydroxypipecolic acid acts as a mobile signal for systemic acquired resistance

www.sciencedirect.com/science/arti...

Brassinosteroid-regulated transcription factors confer epigenetic changes that repress plant immunity

www.biorxiv.org/content/10.6...

Subfamily I ethylene receptors are functionally conserved in calcium permeability across the green lineage #research #MolecularPlant cell.com/molecular-pl...

A plant-specific calmodulin-binding protein, AtCBP60b, mediates Ca2+ dynamics and signaling responses and is critical for plant growth and development in a temperature-dependent manner Abstract. Calcium (Ca2+) is an essential mineral nutrient and a vital signaling molecule for plant growth and development. Ca2+/calmodulins (CaMs) can bind

A plant-specific calmodulin-binding protein, AtCBP60b, mediates Ca2+ dynamics and signaling responses and is critical for plant growth and development in a temperature-dependent manner

academic.oup.com/jxb/advance-...

Jasmonate before salicylate in systemic acquired resistance Systemic acquired resistance (SAR) has long been viewed as a salicylate-driven process. Recent evidence by Gaikwad et al. reveals an earlier, jasmonate- and calcium (Ca2+)-dependent systemic phase tha...

Jasmonate before salicylate in systemic acquired resistance

www.cell.com/trends/plant...

Mapping plant cell-type-specific responses to environmental stresses Plants constantly encounter diverse biotic and abiotic stresses that threaten their survival and productivity. With climate change intensifying the severity of these stressors, a deeper understanding ...

Mapping plant cell-type-specific responses to environmental stresses

www.cell.com/trends/plant...

The MicrobeAtlas database: Global trends and insights into Earth’s microbial ecosystems MicrobeAtlas (www.microbeatlas.org) is an integrated, reference-based resource for truly planet-wide microbiomics, analyzing hundreds of thousands of microbial lineages across diverse environments, conditions, and technologies.

Now online! The MicrobeAtlas database: Global trends and insights into Earth’s microbial ecosystems

Planetary microbiome structure and generalist-driven gene flow across disparate habitats A planetary-scale analysis of over 85,000 metagenomes establishes a framework for exploring the structure and drivers of global microbial habitats, revealing that generalist species bridge ecological boundaries to mediate gene flow across disparate habitats, including the dissemination of antimicrobial resistance.

Now online! Planetary microbiome structure and generalist-driven gene flow across disparate habitats

Asymmetric selection of a rice immune module and rebuild of disease resistance - Nature Stacking XA48-mediated effector-triggered immunity with XA21-mediated pattern-triggered immunity in Oryza sativa japonica reconstitutes the broad-spectrum resistance from wild rice.

Asymmetric selection of a rice immune module and rebuild of disease resistance

www.nature.com/articles/s41...

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform Mammalian switch/sucrose nonfermenting (mSWI/SNF) chromatin remodeling complexes modulate DNA accessibility and gene expression; however, their genomic targeting mechanisms remain incompletely underst...

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform

www.science.org/doi/10.1126/...

Protein and genomic language models uncover the unexplored diversity of bacterial immunity The bacterial pangenome contains a vast diversity of antiphage systems, whose overall extent is still unknown. In this study, we developed complementary machine learning approaches to systematically p...

Protein and genomic language models uncover the unexplored diversity of bacterial immunity

www.science.org/doi/10.1126/...

DefensePredictor: A machine learning model to discover prokaryotic immune systems Antiphage defense systems protect bacteria from viral infection and have inspired important biotechnologies such as CRISPR-Cas9 while also revealing the evolutionary roots of eukaryotic innate immunit...

DefensePredictor: A machine learning model to discover prokaryotic immune systems

www.science.org/doi/10.1126/...

Simultaneous Quantification of Salicylic Acid, Pipecolic Acid, and N-Hydroxypipecolic Acid in Plants Using High-Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry Plant immune activation in response to disease-causing pathogens entails proper spatiotemporal regulation of plant hormones and defense-activating metabolites. In Arabidopsis thaliana and numerous pla...

Excited to share our #MethodsMolBiol paper on LC-MS-based quantification of plant immune signals salicylic acid, pipecolic acid & N-hydroxyPip!

This was an excellent collaboration with Lingya and Xiufang. Thanks to @smukhtarlab.bsky.social for editing this volume!
link.springer.com/protocol/10....

General scales unlock AI evaluation with explanatory and predictive power - Nature A fully automated methodology based on rubrics capturing a broad range of cognitive and intellectual demands is illustrated using LLMs and tasks, demonstrating a new way to evaluate the capabilities o...

www.nature.com/articles/s41...

Gene regulatory landscape dissected by single-cell four-omics sequencing - Nature Combining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome pr...

Gene regulatory landscape dissected by single-cell four-omics sequencing

www.nature.com/articles/s41...

Viruses 'eavesdrop' on each other—but it can backfire University of Exeter scientists studied chemical communication by phages (viruses that infect bacteria). The phages assessed in the study have two choices when they enter a cell: lie dormant or kill the cell and release new virus particles to infect other cells nearby.

Phages can intercept chemical signals from other virus species, but responding to these signals may lead to less optimal decisions for the eavesdropping phage. doi.org/hbvf9w

Phages communicate across species to shape microbial ecosystems Gallego-del-Sol et al. show that arbitrium-coding phages can sense non-cognate peptide signals from other phages to regulate lysis-lysogeny decisions. This crosstalk affects lysis-lysogeny outcomes of...

This paper started as an idea @albertomarina.bsky.social had many years ago… which of course means he was right all along 😄. Some of us just needed a few years (and a lot of experiments) to catch up.
Grateful (and slightly humbled) to be part of this. Thanks Alberto!
www.cell.com/cell/fulltex...

Rhizobacteria‐Induced Systemic Priming Against Fungal Pathogens Involves Hydroxycinnamic Acid Amides Untargeted metabolomics in tomato leaves revealed that immunity-inducing root bacteria elevate the hydroxycinnamic acid amides caffeoyl- and feruloyl-putrescine. These metabolites exhibit antifungal ...

Rhizobacteria-Induced Systemic Priming Against Fungal Pathogens Involves Hydroxycinnamic Acid Amides

onlinelibrary.wiley.com/doi/10.1111/...