Eusocial Reproduction Selects for Longevity www.biorxiv.org/content/10.1101/2025.03....

A reciprocal glial circuit calibrates injury information and governs the tissue response balance Brain injury responses must be carefully balanced to limit damage while enabling repair. Luan et al. show that astrocytes and microglia form a reciprocal signaling circuit and achieve balanced ATP rel...

A reciprocal glial circuit calibrates injury information and governs the tissue response balance

I just realised that humans have high cortical folding amongst primates, sort of like shar pei dog skin. Are there any other species with similar cortical folding?

This is interesting from “Matters of size: roles of hyaluronan in CNS aging and disease”. Rodent data shows a strong postnatal HA surge followed by decline.
But in humans?
I can’t find much data, If HA plays a role in development and regeneration, this seems like an area worth looking into!

Matrix composition modulates cancer cell phenotypes and secretions in a blood–brain barrier organ-on-a-chip model: Comparison of collagen and hyaluronic acid Recent advances in organ-on-a-chip (OOC) blood-brain barrier (BBB) models for oncology research have revealed key insights into the metastatic cascade…

Matrix composition modulates cancer cell phenotypes and secretions in a blood–brain barrier organ-on-a-chip model: Comparison of collagen and hyaluronic acid

Rejected from Medical Hypothesis, they did say it was ‘unique’ but didn’t make priority cut.

CD44-mediated meningeal monocyte activity enhances immune surveillance in the central nervous system after traumatic brain injury Download Citation | CD44-mediated meningeal monocyte activity enhances immune surveillance in the central nervous system after traumatic brain injury | Traumatic brain injury triggers a complex immune...

CD44-mediated meningeal monocyte activity enhances immune surveillance in the central nervous system after traumatic brain injury

"Although HA, CSA, and CMC supported comparable numbers of adherent cells, HA exhibited significantly higher adhesion strength. These results demonstrate that cellular adhesion mediated by CD44 displays a nonlinear relationship between adhesion strength and the number of attached cells"

Are the raccoons domesticated? this may explain it..

Survey research is often interpreted as showing that belief in conspiracy theories can be surprisingly widespread, including belief in conspiracy theories that would be astonishing if true. For example, in The Atlantic we learn that “12 million Americans believe lizard people run our country”

Are they domesticated raccoons?

A doctor costume, honestly, not Jesus…

A movie couple that would definitely have a podcast

Praise Je-searchers

Ridiculous..
"Mr Robinson — a former defence force member who served in Afghanistan — told the jury he was "utterly horrified" by the incident, which resulted in the girl's front teeth being knocked out."

Cleavage of Hyaluronan and CD44 Adhesion Molecule Regulate Astrocyte Morphology via Rac1 Signalling Communication of cells with their extracellular environment is crucial to fulfill their function in physiological and pathophysiological conditions. The literature data provide evidence that such a co...

"receptor CD44 enables astrocytes to respond to extracellular signals and decipher them into intracellular signaling pathways, to maintain and modulate their morphology. This mechanism can underlie the morphological changes associated with many physiological and pathological processes in the CNS"

Targeting the hyaluronic acid–CD44 axis in hepatocellular carcinoma Hepatocellular carcinoma (HCC) remains a major global health challenge, with rising incidence, frequent development of drug resistance, and limited long-term survival despite advances in systemic therapies. Within the tumor microenvironment, the interaction between hyaluronic acid (HA) and cluster of differentiation 44 (CD44) is linked to tumor progression and therapeutic failure. Accordingly, targeting the HA–CD44 signaling axis represents a promising strategy to overcome resistance. This review highlights potential approaches, including inhibition of HA synthesis, enzymatic HA degradation, CD44 blockade, and HA-based nanocarriers for selective drug delivery, alone or combined with existing therapies. Leveraging HA–CD44 biology may help refine profiling and support the development of more personalized treatments, ultimately enhancing outcomes for HCC patients.

ONLINE NOW: Targeting the hyaluronic acid–CD44 axis in hepatocellular carcinoma

Luminal surface proteome of the brain vasculature uncovers blood-brain barrier regulators At the blood-tissue interface, vasculature luminal surface is critical for molecular transport, signaling transduction, and cell extravasation. Here, we present a method for proteomic profiling of the...

"the hyaluronan degradation enzyme HYAL2 was found to be required for BBB integrity throughout life"

Check out 2 papers and a related Perspective on tissue regeneration in @science.org this week
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration | Science www.science.org/doi/10.1126/...

Awakening latent regeneration in mammals | Science www.science.org/doi/10.1126/...

Non-canonical roles for Hif-1α in interneuron progenitor proliferation and cortical circuit maturation

"These pathways converge on the HA–CD44 signaling axis, which safeguards centrosome clustering and mitotic fidelity, integrating metabolic and structural adaptations that ensure the survival of genomically unstable CA cells"

Glycobiology: How enzymes make the right choice during biosynthesis

Give it 2 years: Our findings identify ECM composition and mechanics as primary regulators of mammalian development.

"Our findings identify ECM composition and mechanics as a primary mechanism governing mammalian regeneration. By demonstrating that the ECM acts as a mechanochemical signalling hub, we show that “retuning” the physical environment from a stiff, collagenous state to a soft, HA-rich state can.."

Any chance of a recording made available?

Novel use of intrauterine instillation of Hyaluronan enriched media on clinical outcomes of intrauterine insemination treatment: a pilot randomized controlled trial To study the effect of intrauterine instillation of Hyaluronan enriched media on reproductive outcomes of intrauterine insemination treatment.100 coup…

The study provides a concept of proof of benefit of use of hyaluronan enriched media as a novel minimally invasive add-on intervention to facilitate the enhancement of success rates of IUI treatment.

Seed and soil… but what about water?

The Hyaluronan Terrain Hypothesis: Molecular-Weight Dynamics in Development, Ageing, and Disease
osf.io/sd5g4/wiki?w...

Regulating cellular metabolism and morphology to achieve high-yield synthesis of hyaluronan with controllable molecular weights - Nature Communications Biosynthesis of hyaluronan (HA) with controlled molecular weights is challenging due to the poorly understood function of the HA synthase (HAS). Here, the authors characterise and engineer HAS and con...

Stable metabolism allows long chain HA, while disruption leads to shorter chains, potentially shifting ECM signalling.

Human placental matrix hydrogel: A biomaterial for modulating inflammation and promoting repair of refractory diabetic wounds Diabetic wound healing is impaired due to persistent inflammation and dysfunctional angiogenesis, creating a clinical demand for ideal dressings capab…

Human placental matrix hydrogel: A biomaterial for modulating inflammation and promoting repair of refractory diabetic wounds 🤢