Median survival went from 6 months to 13 months. It may not sound like much, but for metastatic pancreatic cancer, this is big, IMO. We finally have something solid to build on in this field.

Most the RAS WT still have mutations in the pathway. I think this drug will be used for some RTK mutant cancers and in NF1 eventually.

Panicking scientists, canceled experiments – federal funding cuts turned my work as a research dean into crisis management When the Trump administration took aim at higher education and the scientific research enterprise, a university dean had to figure out on the fly how to support scientists and their work at his school...

theconversation.com/panicking-sc...

The immune system is a struggle, the nomenclature alone makes my eyes glaze over. If it wasn’t covered in Osmosis Jones it takes a lot of effort to try and keep up.

So true!!!

I agree!

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But Michigan won 😊. Although now that I work at Michigan State I’m not sure if I am allowed to point that out.

Drugging RAS: What a Long, Strange Trip It’s Been – Channing Der addressed this topic in a keynote address to open the AACR Special Conference on RAS Oncogenesis and Therapeutics.
#AACRras26

Dieter Saur, Zachary Hauseman, James Duncan, and Jennifer Klomp discussed "Effector Signaling" in a plenary session at the AACR Special Conference on RAS Oncogenesis and Therapeutics.
#AACRras26 @saurlab.bsky.social

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Disappointing but we can still be friends.

This post right here convinces me we would be friends if we ever met in real like. If you posted about “Empire Records” I would say best friends 😆

In 1950, the Noyes criteria was established for determining the optimal window of implantation

@gregoryburns.bsky.social, @emmanuelpaul.bsky.social, Nataki C. Douglas & team now identify an epithelial receptivity signature & stromal changes supporting embryo implantation: doi.org/10.1172/jci....

It is my version of Groundhog Day. I go find the sun and warm weather for a week and then I get the needed boost to get through the rest of winter.

We will be in FL that week, I learned from last year and planned a southern retreat for February 😊

Move back to Michigan they said… it doesn’t snow like it used to… the winters aren’t that bad 🤦‍♀️

I agree it is very pretty 😆

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Very well deserved! Congratulations.

What do you do if there have already been 2 snow days this week and you actually want/need there not to be another and it is STILL snowing?

This spot sits just east of Holland, my hometown. I used to drive this route a lot. The lake effect whiteouts would appear like walls in the distance. Inside was blinding whether day or night. I remember the routine: flipping on the hazard lights, driving white knuckled, and praying until Exit 55.

I grew up in Hudsonville just over a month ago was driving from Ann Arbor to Holland in a snowstorm and chose to take Chicago drive just to avoid that part of the highway.

The other day as I contemplated whether one resubmits a “Competitive-ND” or does a new submission… I thought at least I’m wearing corduroys again.

Don’t forget your corduroys. I bought 2 pairs recently 😊.

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I knew I did all those revisions for a reason 😆

We will try not to corrupt you this year by bringing you to breweries 😆

Do we know if Sacks did this whole career or were some of his earlier works more accurate (Awakenings and Migraine for example)? Very disappointing but just curious if this was ubiquitous throughout his career.

I’m going with pure genius for me 😆

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