🧑🔬📰🚀 #RxivMaker is here! A framework automating the creation of publication-ready scientific #preprints from simple Markdown. Goodbye manual formatting, and hello gorgeous manuscripts! A great adventure with @guijacquemet.bsky.social's lab
📜: zenodo.org/records/1575...
👨💻: github.com/HenriquesLab...
We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design!
github.com/martinpacesa...
Barcoded viral tracing identifies immunosuppressive astrocyte–glioma interactions @quintanalabhms.bsky.social @nature.com
www.nature.com/articles/s41...
Introducing Arc Institute’s first virtual cell model: STATE
@saramostafavi.bsky.social (@Genentech) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/
If post doc opportunities in ML for genomics were a mountain, then perched at the summit, straddling the border between impossibly alluring and actually real, sits this. You. Should. Apply.
Join the @steinaerts.bsky.social Lab via the VIB.AI International PhD Call 2025!
Use ML to decode how DNA sequences control gene activity.
Work with single-cell & spatial genomics, deep learning models, and CRISPR validation.
📍 Leuven
🗓️ Apply by June 22nd → https://tinyurl.com/53nc9vnd
FutureHouse's goal has been to automate scientific discovery. Now we used our agents to make a genuine discovery – a potential new treatment for one kind of blindness (dAMD). We had multiple cycles of hypotheses, experiments, and data analysis – including identify the mechanism.
Congrats! Thanks for the acknowledgement. Happy to contribute in a tiny way.
A triumph of perseverance from twitterless Tom Weber, Christine Biben and the team, our in vivo barcoding "LoxCode mouse" used to resolve epiblast fate to fetal organs is finally published in @cellpress.bsky.social and available through @jacksonlab.bsky.social www.sciencedirect.com/science/arti...
Australia completely lacks a dedicated training program for clinician scientists. With the vision and support of VMIAL
@petermaccc.bsky.social is extremely proud to announce the first clinician-scientist fellowship. If you meet the eligibility criteria PLEASE APPLY!
www.nature.com/naturecareer...
Start a lab in Australia @wehi-research.bsky.social. and don't assume we're a scientific backwater. WEHI had Science, Cell and Nature Medicine papers among others all in the last month. Wet have a kick ass environment that values discovery, translation and spin outs.
i believe there are major implications for single-cell ATAC-seq, with possibly strong cell type-dependent Tn5 activity differences making it difficult to sample heterogeneous cell populations effectively.
scATAC has been slow to take off, and variable data quality could be a big reason why
Inverse folding NNs are better at predicting changes to a mutated protein's equilibrium dynamics, relative to WT, than protein folding NNs (BioEmu & AF-Cluster). This was shown on an enzyme that is more enzymatically promiscuous in the open state.
🔬 Working with #spatial biology or keen to explore its potential?
Register now for the WEHI Spatial Technology Symposium 2025!
🔎 Expert talks, poster presentations & networking
📍 At WEHI and online
👇 Event info and registration
Our speaker next week is an amazing scientist from out of town, and this is one that you won't want to miss!
Thursday, May 15th, 7pm EDT
Cannon Room, Building C, @harvardmed.bsky.social
Sarel Fleishman
www.fleishmanlab.org
"Designing new and improved functions in natural protein folds"
bpdmc.org
Madhavi Krishnans lab with an absolutely amazing new measurement technique:
Measurements of molecular size and shape on a chip | Science www.science.org/doi/10.1126/...
We will put forward a 500 million package for 2025-2027 to make Europe a magnet for researchers.
As well as ambitious proposals for R&I in the next EU budget.
We will also offer the best and brightest the right incentives to come to Europe ↓
Huge thanks to Koen Theunis and the brilliant collaborators: @dviousmind.bsky.social @leuccilrcb.bsky.social @jdemeul.bsky.social @marinelab.bsky.social and Thierry Voet for making this possible! (8/9)
Overview of Lyra
State-space models naturally model epistatic relationships in their hidden states. An SSM with 55k parameters to matches models with hundreds of millions of parameters for predicting the properties of biological sequences.
@krithik-bs.bsky.social @sameedms.bsky.social
@pardissabeti.bsky.social
New research article from the lab led by the amazing @amydashwood.bsky.social !
In collaboration with @vib-switch-lab.bsky.social @cbdresearch.bsky.social we engineered variants of #IL2 designed for therapeutic use. 1/11
www.sciencedirect.com/science/arti...
Check out this talk from our own Garyk Brixi talking about Evo 2!
Labeling your axes and then explaining them slowly is perhaps the biggest bang for the buck you can get for making your slides more understandable.
Very excited our work out in @jem.org “Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection”
@wehi-research.bsky.social led by talented (and determined) PhD student @benjbroom.bsky.social
Thread below.
L-R: Professor Vihandha Wickramasinghe, WEHI laboratory head and Inaugural Moderna Australia Fellow, Dr Kate Jeffrey, Moderna’s vice president and global head of immune therapeutics and genomic sciences, Professor Ken Smith, WEHI director, and Felicia Pradera, director of the Regional Research Centre for Respiratory Medicines and Tropical Diseases at Moderna.
Accelerating life-saving therapies, together. WEHI is partnering with Moderna in an Australian-first that will advance research into mRNA medicines for autoimmune diseases.
Learn more👉 www.wehi.edu.au/news/austral...
we recently found some really neat RNA-guided DNA-cutting systems in phages. Despite remarkable similarities to CRISPR systems, including encoding guide RNAs in arrays, they appear entirely evolutionarily distinct (but definitely related to snoRNAs 🤓)
We decided to call them TIGR-Tas systems 🐯
We @prescientdesign.bsky.social Genentech pre-printed our "Lab-in-the-loop for therapeutic antibody design." We built a general ML system to accelerate molecule design for challenging, therapeutically relevant targets.
www.biorxiv.org/content/10.1...
