First of its kind research shows the potential role of coffee as a further intervention to promote positive gut health and its effects on the gut-brain axis. Photo (L-R): Professor John Cryan, Dr Serena Boscaini and Dr Gerard Moloney. Image credit: Provision.

Coffee may influence mood & stress through the gut microbiome, not just caffeine.
A new paper in 𝑵𝒂𝒕𝒖𝒓𝒆 𝑪𝒐𝒎𝒎𝒖𝒏𝒊𝒄𝒂𝒕𝒊𝒐𝒏𝒔 studied 31 coffee & non coffee drinkers. Both caffeinated & decaf coffee were linked to lower stress & mood scores, alongside shifts in gut microbes & metabolites.
📰 buff.ly/VwaUKiX

It was a privilege to have contributed to this exciting work on coffee and the microbiota-gut-brain axis (as I currently sip on my third coffee of the day 😀)

Congrats to first authors Serena Boscaini, Gerry Moloney, & @biothomaz.bsky.social & @jfcryan.bsky.social!

@ucc-apppsych.bsky.social

☕☕☕

The gut #microbiome may relate to mental health in later life. A new paper in @plosone.org studied 153 older Chilean adults with cognitive complaints and linked neuroactive microbial pathways with cognitive and psychological measures. @bvalderrama.bsky.social @jfcryan.bsky.social #GutBrainAxis

Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis - Nature Metabolism This Review provides an overview of the interplay between host diet and the gut microbiota, and how this affects brain function.

#Throwback 🧪

REVIEW | Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis

@elizschneider.bsky.social‬
@jfcryan.bsky.social et al

Impressive keynote from @jfcryan.bsky.social #MicrobiomePTsummit in Lisbon
From brain development to ageing and stress response…
our microbiota is involved at every step
Once again, he delivered a powerful vision of the gut–brain axis. @anasalmeida.bsky.social

Pesticides may wreak havoc on the gut microbiome
Disruption of intestinal ecosystem could contribute to diabetes & other health issues, scientists say
I enjoyed discussing our research on the impact of pesticides on the microbiome with Sanket Jain for @science.org

www.science.org/content/arti...

“Everything interesting begins with one person and one place”

Great to get a sneak peek of The John McGahern Museum at the Barracks in Cootehall, Co. Roscommon - Thanks Michael Cryan
Definitely worth a detour over the summer months if people are up West

Theatrical poster for the Iranian film It Was Just An Accident. Beneath a clear blue sky, a dirty white van is parked in the desert. A group of five people are gathered around it, two of them a bride and groom sitting in the open back of the van facing the setting sun. The bride is wearing her white wedding dress which looks very incongruous in the dusty context.

I think this might have been a perfect film? Soooooo good!
So assured in every way, from the opening scene right through to the brilliant final shot. Can't recommend it highly enough, do yourself a favour and watch it. You can rent it on the streamers for a couple €€

Your gut may shape how the brain reads hunger and food reward.

A new review in @ibrojournals.bsky.social Neuroscience proposes a framework linking microbiome research in eating disorders with interoception and reward.
📰 Read: buff.ly/679j1RQ

#Microbiome #Neuroscience #EatingDisorders #BrainGutAxis

Pleased to share our latest review led by the dream team, Bella Ziade and Meghan McDermott, with @kjdoriordan.bsky.social and @jfcryan.bsky.social, where we discuss a potential integrated mechanism of the gut microbiome, interoception, and reward across all eating disorders:
doi.org/10.1016/j.ne...

Huge congratulations to Dr Ramya Balasubramanian (@rabal97.bsky.social )on her PhD graduation 🎓

Wishing her all the best for the next chapter at the University of Calgary — you’ll be missed!

With proud APC supervisors John Cryan (@jfcryan.bsky.social )and Paul Cotter (@pauldcotter.bsky.social)👏

Congratulations to @jfcryan.bsky.social and Gerard Clarke on their election as Fellows of the European Academy of Microbiology 👏

A fantastic recognition of their contributions to microbiome science and the gut–brain axis.

#Microbiome #Research @uccresearch.bsky.social

buff.ly/LqJ7Njp

Magnificent and truly inspiring presentation by Prof. John Cryan! @jfcryan.bsky.social #MicrobiomeToLife2026

Antipsychotic-related weight gain may be linked to changes in the gut microbiome. A review published in Dialogues in Clinical Neuroscience reviewed 24 papers and found consistent microbiome shifts linked to metabolic side effects.
📰 buff.ly/7hGze8O
#microbiome #gutbrainaxis
Collaborators below⬇️

Serotonin’s role in mental health is more complex than we thought Recent research has opened the debate on whether chemical imbalances cause depression, anxiety, and other conditions

Serotonin’s role in mental health is more complex than we thought

“I’ve been trying to get away from working on serotonin for a long time,” says John F. Cryan, “And I can’t because every time I leave serotonin, it keeps coming back.”
cen.acs.org/pharmaceutic...

Diet is one of the major modulators of the microbiota-gut-brain axis across the lifespan. Milk bioactive components, including human milk oligosaccharides such as fucosyllactose and sialyllactose, and prebiotics, including GOS and FOS, promote the viability of commensal bacteria, fortify the intestinal barrier, and improve cognitive development. Here, we investigate the ability of these dietary components alone or in combination to counter the behavioral and physiological effects of early-life microbiota depletion via broad-spectrum antibiotics in mice.

Early-life changes to the gut microbiome can affect social behaviour.
A study published in @cp-iscience.bsky.social found certain diet ingredients helped restore that response and changed brain pathways linked to learning and development.
buff.ly/YeQk7LV
#GutBrainAxis #Microbiome
Collaborators⬇

Great summary by @maclomaclee.bsky.social of efforts to improve the reproducibility and integrity of research @ecnp.eu Workshop today

Today in @nature.com, the @christophthaiss.bsky.social & @maayanlevy.bsky.social labs trace age-related memory loss to the gastrointestinal tract & map the complete gut-to-brain pathway driving it. Targeting this pathway can reverse cognitive aging in mice.

www.nature.com/articles/s41...

I really enjoyed taking part in the @shushradio.bsky.social Takeover at @ucc.ie where I had the chance to choose a few favourite songs and talk about the importance of libraries in research and innovation.

Thanks @martinoconnor.bsky.social for expert hosting
Listen: soundcloud.com/shush-radio-...

It's #InternationalWomensDay -always a timely reminder of what a privilege it is to work with such an incredible, creative (and very international) group of female scientists in the Microbiota-Gut-Brain Axis lab at APC Microbiome Ireland @apcmicrobiomeirel.bsky.social , @ucc.ie
#iwd2026 #iwd26

Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis - Nature Metabolism This Review provides an overview of the interplay between host diet and the gut microbiota, and how this affects brain function.

#Throwback 🧪

REVIEW | Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis

@elizschneider.bsky.social‬, ‪@jfcryan.bsky.social et al

The big lecture is drawing near. While #Monahan26 is free of charge, registration is essential. Send an email to government@ucc.ie 👍.

@ucc.ie @corkbeo.bsky.social @joh2024.bsky.social @jfcryan.bsky.social @theresareidy.bsky.social @irishtimes.com

An unhealthy diet disrupts feeding behavior and the gut microbiota, but whether early-life dietary effects persist, or can be restored later in life, remains unclear. We investigated whether microbiota-targeted interventions (FOS + GOS or Bifidobacterium longum APC1472) could restore early-life highfat/ high-sugar (HFHS) diet-induced feeding alterations in adult female and male mice.

New APC paper in Nature Comms
First author Cristina Cuesta-Marti and colleagues examine how eating unhealthy foods early in life leaves lasting brain and feeding changes but bacteria can help restore healthy eating.

www.nature.com/articles/s41...
#Microbiome #GutBrainAxis
Tagging collaborators ⬇️

If you missed @jfcryan.bsky.social and Ted Dinan talking with Síle Seoige on @tg4.bsky.social last night, you can watch in on the player. They are talking about their research on gut feelings and #anxiety.
#microbiome #gutbrainaxis
@uccresearch.bsky.social

What a great way to kick off our UCC Futures Lecture Series with Agustin Ibanez on campus talking about “Rethinking Brain Aging in the Big Data World” - Neuroscience meets Social Science meets Big Data

@moloneyger.bsky.social @bvalderrama.bsky.social @uccresearch.bsky.social

If you missed @jfcryan.bsky.social and Ted Dinan talking with Síle Seoige on @tg4.bsky.social earlier this week catch it again 𝐭𝐨𝐧𝐢𝐠𝐡𝐭 𝐚𝐭 𝟗𝐩𝐦 . They talking about their research on gut feelings and #anxiety.
#microbiome #gutbrainaxis
@uccresearch.bsky.social

Pages 20-21 of the Ticket from the Irish Times with a review of Irish Romanticism: A Literary History by Claire Connolly.

Very pleased with my first piece for the @irishtimes.com - a review of @claireconnolly.bsky.social new book, Irish Romanticism: A Literary History. Thank you @martindoyle.bsky.social for the opportunity!

Congratulations to wonderful colleague @claireconnolly.bsky.social on her new book, Irish Romanticism: A Literary History, launched this evening by @jfcryan.bsky.social, VP for Research & Innovation @ucc.ie, and Prof. Clair Wills, King Edward VII Prof. of English Literature at Cambridge.

What a great way to end the week! Thanks @jfcryan.bsky.social for the fantastic talk and discussion ! We are all delighted here @cbitoulouse.bsky.social

Fascinating new link between stress, liver tryptophan metabolism, and liver cancer in this new article @natmetabolism.nature.com www.nature.com/articles/s42...

We unpack it in our Nature Metabolism News & Views with John Cryan & Gerard Clarke, have a read: rdcu.be/eZHvs