how did I only just become aware of Spicy Pepper Pokémon Scovillain, which evolves from Capsakid and has a “spicy rage attack”.

A hypoxia-sensitive medullary nucleus modulates cerebral blood flow via a disynaptic pathway to cortex www.biorxiv.org/content/10.64898/2026.02...

Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.

Acute threats modulate hunger circuit dynamics to instruct avoidance behaviour www.biorxiv.org/content/10.64898/2026.02...

Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition www.biorxiv.org/content/10.64898/2026.02...

A scalable approach to resolving variants of uncertain significance www.biorxiv.org/content/10.64898/2026.02...

Genome-wide single-cell perturbation screens with VIPerturb-seq www.biorxiv.org/content/10.64898/2026.02...

Genomic insights into substance use and disinhibitory disorders Externalizing spectrum disorders- spanning attention-deficit/hyperactivity disorder, conduct disorder, substance use disorders, and other disorders characterized by disinhibition - frequently co-occur...

Our multi-ancestry GWAS of EXTernalizing conditions (ADHD, substance use...) in ~4M people reveals neurodevelopmental risk, drug-repurposing targets, and yields one of the strongest psychiatric polygenic indices yet! 🧬🎉 doi.org/10.64898/202...

Identification of a neural basis for anorexia nervosa www.biorxiv.org/content/10.64898/2026.02...

Sex-specific control of feeding and defensive behaviors by MC3R neurons in the bed nuclei of the stria terminalis www.biorxiv.org/content/10.64898/2026.02...

A multi-omics atlas of human hindbrain development www.biorxiv.org/content/10.64898/2026.02...

🧬 New preprint alert! After years of collaborative work across 52 datasets we are presenting eQTLGen phase 2: a genome-wide eQTL meta-analysis covering 43,301 blood samples: www.medrxiv.org/content/10.6... (1/8)

A modular transcript enrichment strategy for scalable, atlas-aligned, and clonotype-resolved single-cell transcriptomics www.biorxiv.org/content/10.64898/2026.02...

dplyr 1.2.0 dplyr 1.2.0 fills in some important gaps in dplyr's API: we've added a new complement to `filter()` focused on dropping rows, and we've expanded the `case_when()` family with three new recoding and re...

dplyr 1.2.0 is out now and we are SO excited!

- `filter_out()` for dropping rows

- `recode_values()`, `replace_values()`, and `replace_when()` that join `case_when()` as a complete family of recoding/replacing tools

These are huge quality of life wins for #rstats!

tidyverse.org/blog/2026/02...

You can easily switch between magrittr pipe `%>%` and base pipe `|>` in the RStudio settings 🧰

#rstats #dataviz #phd

Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human Brain www.biorxiv.org/content/10.64898/2026.02...

A projection atlas of excitatory and inhibitory inputs to the preBötzinger Complex: substrates for multimodal breathing control www.biorxiv.org/content/10.64898/2026.02...

Advancing regulatory variant effect prediction with AlphaGenome - Nature AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...

I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵
www.nature.com/articles/s41...

A Single-Cell and Spatial 3D Multi-omic Atlas of Developing Human Basal Ganglia and Inhibitory Neurons www.biorxiv.org/content/10.64898/2026.01...

Scientific Paper Planner - AI-Powered Research Planning Structure your scientific research with AI-powered guidance. From hypothesis to methodology, plan your research paper with intelligent mentoring.

First week where planyourscience.com had more than 1000 organic users. I know this is nothing by software standards but it is quite something by academic standards. And to everyone using it - tell me what could/should be better. And use it to export a first draft ;)

SqueakPose Studio: An end-to-end platform for pose estimation and real-time edge-AI deployment www.biorxiv.org/content/10.64898/2026.01...

Bright calcium-modulated bioluminescent indicators for activity imaging and red photon-assisted synaptic transmission www.biorxiv.org/content/10.64898/2026.01...

New preprint on technologies to scale up CRISPR screens.

We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells.

We also introduce an approach for cloning lentiviral libraries with billions of elements.

TL;DR: Indirect costs as a percentage of total costs - like the private sector tends to calculate it - for NIH grants is typically around 30-35%.

I'd be interested!

New revolutionary hack about to change our molecular tool-box!

Thanks @ioavlachos.bsky.social for sharing this!

Rapid evolution of a highly efficient RNA polymerase by homologous recombination

www.nature.com/articles/s41...

a man wearing a plaid shirt and a purple hat is saying here we go . ALT: a man wearing a plaid shirt and a purple hat is saying here we go .

Our paper on the Expanded Registry of candidate cis-Regulatory Elements (cCREs) is out 🎉
www.nature.com/articles/s41...

To celebrate, here’s a "meme-torial" walkthrough of the science.

Let’s get started 🧵 1/11

Multiplexed measurements of protein-protein interactions and protein abundance across cellular conditions using Prod&PQ-seq www.biorxiv.org/content/10.64898/2026.01...

A free, open-access library of high-quality organism illustrations for science communication We create vector graphics of model organisms and emerging biological research organisms to enhance our publications. We’re sharing these editable graphics under a CC0 license for other scientists to...

A free, open-access library of high-quality organism illustrations for science communication

Just quit Quitting projects in science is hard, but we should be doing a lot more of it.

Blog post: Just quit
Quitting projects in science is hard, but we should be doing a lot more of it.

open.substack.com/pub/arjunraj...