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Posts by Julien Limenitakis

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Diet-derived LPS determines intestinal IgA induction and repertoire characteristics independently of the microbiota The microbiota’s impact on immune development is well appreciated. Mooser et al. show now that dietary LPS promotes intestinal germinal center reactions and IgA production independently of the microbi...

Interested in the effects of diets on B cell repertoires ? Have a look at our new publication: "Diet-derived LPS determines intestinal IgA induction and repertoire characteristics independently of the microbiota" www.cell.com/immunity/ful... This work was done at @unibe.ch. Share if you like it.

9 months ago 2 0 0 0
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It's an exciting moment for immune repertoire research! At the end of December in Cell Systems, we shared our perspective on recent advances in ML for immune repertoire interpretation: www.sciencedirect.com/science/arti...

1 year ago 4 3 1 0
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Imprint FRO IMPRINT is developing tools to read and analyze immune memory signatures, providing a new approach to identify hidden causes of chronic disease.

Beyond advancing impactful science, Imprint offers a unique culture as a Focused Research Organization (FRO).

FROs are non-profit, impact-driven moonshot initiatives, combining philanthropic support with startup-like agility to tackle humanity's biggest challenges.

Learn more about Imprint:

11 months ago 4 2 1 0
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Jobs — Imprint FRO Join our team—current openings at Imprint

Looking for a job in immunology or biotech research?
✨IMPRINT is #hiring! ✨

Join us to help revolutionize how we decode the body’s immune memory, uncover the causes of chronic diseases, and drive breakthroughs in autoimmunity and neuropsychiatric research.

#BiotechJobs #Immunology #sciencejobs

11 months ago 8 9 1 1
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The AIRR Community Meeting VII #AIRRC7 is starting this Monday, June 3rd, at the University of Porto! A huge thank you to our sponsors. Your support is invaluable! Check out the full agenda and more details on the meeting page: tinyurl.com/airrcmeeting7
#Immunology

1 year ago 2 1 0 0
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Bizarre bacteria defy textbooks by writing new genes Bacterial defensive systems scramble the standard workflow of life. Bacterial defensive systems scramble the standard workflow of life.

A new variety of reverse transcriptase discovered in bacteria “reads RNA as a template to make completely new genes written in DNA. These genes are then transcribed back into RNA, which is translated into protective proteins when a bacterium is infected by a virus.”

🐋🌱🧪🦋🦫 #EvoBio

1 year ago 26 12 1 1
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AIRR Community Meeting VII - Learnings and Perspectives - The Antibody Society 15 years after the first AIRR-seq sequencing, what have we learned in the basic and biomedical research fields? What is next? Join us at the AIRR-C Meeting in Porto this June, the premiere event for g...

Register for the AIRR-C 7 meeting! Once registered, remember to sign up for the workshops and tutorials through the meeting app!. Also, if you haven’t already be sure to sign up for the fabulous Cálem Port Wine Cellars Tour & Group Dinner. www.antibodysociety.org/the-airr-com...
#AIRRC7 #Immunology

1 year ago 1 1 0 0
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Our bit for PLOS Bio’s special on symbiosis thinking about the (under-appreciated) role of fitness trade-offs in the origins of endosymbiosis journals.plos.org/plosbiology/...

2 years ago 15 6 0 0
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In new study led by Andrea Loes, we develop sequencing-based neutralization assay that measures replicate curves for hundreds of virus-serum pairs per 96-well plate (see image below)
www.biorxiv.org/content/10.1...
 
We apply assay to characterize response to repeat influenza vaccination

2 years ago 16 13 2 1

Addressing technical pitfalls in pursuit of molecular factors that mediate immunoglobulin gene regulation biorxiv.org/cgi/content/... #biorxiv_genomic

2 years ago 2 1 0 0
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Single-cell genomics meets human genetics - Nature Reviews Genetics In this Review, the authors describe the emerging field of single-cell genetics, which lies at the intersection of single-cell genomics and human genetics. They review the first single-cell expression...

Review: Single-cell genomics meets human genetics www.nature.com/articles/s41... 🧬🖥️

2 years ago 2 4 0 0
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Bioframe: operations on genomic intervals in Pandas dataframes AbstractMotivation. Genomic intervals are one of the most prevalent data structures in computational genome biology, and used to represent features ranging from

Bioframe: operations on genomic intervals in Pandas dataframes academic.oup.com/bioinformati... 🧬🖥️ github.com/open2c/biofr...

2 years ago 7 4 0 0
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Frontiers | An optimized culturomics strategy for isolation of human milk microbiota <p>Viable microorganisms and a diverse microbial ecosystem found in human milk play a crucial role in promoting healthy immune system and shaping the microbi...

An optimized culturomics strategy for isolation of human milk microbiota www.frontiersin.org/journals/mic... #jcampubs

2 years ago 1 1 0 0
A diagram titled 'Hallmarks of Cancer Research', designed in a clean, academic style, including funding, trend chasing, glam papers, and big data.

A diagram titled 'Hallmarks of Cancer Research', designed in a clean, academic style, including funding, trend chasing, glam papers, and big data.

The Hallmarks of Cancer Research 🧪

2 years ago 30 11 5 0
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Thrilled to share our latest paper on commensal colonization during early life! This study explores how human milk oligosaccharides trigger the colonization program in Bacteroides fragilis. 🦠🧫🧪 www.sciencedirect.com/science/arti...

2 years ago 6 7 1 0
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A nice summary by Jon Cohen
'COVID'S COLD COUSINS'
www.science.org/content/arti...

2 years ago 17 7 2 0
Stochastic Models and Experiments in Ecology and Biology (SMEEB) 2024 L'Aquila, Italy from May 28th to 31st, 2024 poster

Stochastic Models and Experiments in Ecology and Biology (SMEEB) 2024 L'Aquila, Italy from May 28th to 31st, 2024 poster

Stochastic Models and Experiments in Ecology and Biology (SMEEB) 2024 L'Aquila, Italy from May 28th to 31st, 2024

Theory, experiment and data in microbial ecology, evolution and systems biology!

Featuring @saramitri.bsky.social and @seppekuehnlab.bsky.social
#evosky #livingmatter

2 years ago 9 10 1 1
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Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

In new study led by Frances Welsh, we map how mutations to influenza affect neutralization by antibodies from humans of various ages
 
We find differences in mutation effects among age groups
 
Virus seems to evolve especially to escape antibodies of teenagers
 
www.biorxiv.org/content/10.1...

2 years ago 39 19 2 0

Closing out the year with a fresh preprint! 🤓🧪

2 years ago 8 3 1 0

A very nice method for detection of sweeps in gut microbial populations:

2 years ago 30 13 1 0

New paper on statistical predictions of bacterial traits from genomes. This is a deep technical dive into the intricacies of how to perform these predictions, when and how they work, and when they can reveal underlying mechanisms. journals.plos.org/ploscompbiol...

2 years ago 19 14 1 0
Functional and evolutionary significance of unknown genes from uncultivated taxa - Nature Nature - Functional and evolutionary significance of unknown genes from uncultivated taxa

Extremely excited to share that our effort to identify and characterize novel gene families exclusive of uncultivated taxa is now published in Nature!

www.nature.com/articles/s41...

2 years ago 25 14 1 1
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Multistability driven by cooperative growth in microbial communities bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Multistability driven by cooperative growth in microbial communities www.biorxiv.org/content/10.1... #jcampubs

2 years ago 5 2 0 0
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Hybracter: Enabling Scalable, Automated, Complete and Accurate Bacterial Genome Assemblies bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Hybracter: Enabling Scalable, Automated, Complete and Accurate Bacterial Genome Assemblies www.biorxiv.org/content/10.1... #jcampubs

2 years ago 3 2 0 0
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A big step forward in the science of aging: organ-specific tracking via plasma proteins
www.nature.com/articles/s41...
20% of people assessed had accelerated aging in 1 organ, 1.7% multi-organ

2 years ago 41 16 0 1
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Gaining life expectancy up to a decade longer with a healthy diet nature.com/articles/s43...

2 years ago 48 21 3 2
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The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chron... This study shows that chronic brain infection with African trypanosomes induces broad meningeal responses resulting in the development of ectopic lymphoid aggregates containing autoreactive B cells; m...

I’m so proud of @juanquintana.bsky.social for his latest paper & to have played a (very) small part in it! Interested in the brain, autoimmunity, B cells & parasitic infection? Then this is the pajar for you! 🧪🧬🔭 #LGBTQSTEM #Immunosky

2 years ago 14 7 1 0

On the 10 years anniversary of bioRxiv, John and I discuss the birth of bioRxiv, embedding sci comm within CSHL, the the pandemic, and career options for young scientists in a new podcast ebrcintranslation.buzzsprout.com/1581817/1390...

2 years ago 22 12 0 0
Conference Poster

Conference Poster

EMBO|EMBL Symposium

AI and Biology

12-15 March 2024 in Heidelberg
with an exciting line-up of invited speakers and interactive sessions.
Submit your contributed talk before 5 Dec.

www.embl.org/about/info/c...

2 years ago 10 6 0 1
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Defining the minimal components of the influenza A virus replication machinery via an in vitro recon... The influenza A virus genome is composed of eight single-stranded RNA segments. This study reconstitutes the replication of RNA genome segments in a test tube, using purified viral and host proteins, ...

Influenza virus RNA genome segments undergo a full cycle of replication in a test tube in the presence of viral RNA polymerase, viral nucleoprotein and human ANP32B, an essential host factor for influenza virus genome replication.
journals.plos.org/plosbiology/...

2 years ago 28 17 0 2