Cancer mtDNA mutations: metabolic plasticity and therapeutic promise? Mitochondria, once viewed mainly as cellular powerhouses, are now recognised as key regulators of cancer metabolism, redox balance, and immune interactions. While early models emphasised a switch to a...

Cancer mtDNA mutations: metabolic plasticity and therapeutic promise? www.cell.com/trends/molecular-medicine/fulltext/S1471-4914%2826%2900033-X

Cell biology: Killing the prisoner escaping from mitochondria
www.sciencedirect.com/science/arti...

Emerging mechanisms of genome degradation during the mtDNA life cycle - Nature Cell Biology Mitochondrial DNA (mtDNA) is not static but undergoes a regulated ‘life cycle’ that encompasses replication, maintenance, spatial distribution and turnover. Here, we update emerging mtDNA degradative ...

Emerging mechanisms of genome degradation during the mtDNA life cycle
www.nature.com/articles/s41...

Mitochondrial transfer from immune to tumor cells enables lymph node metastasis How cancer cells subvert immunity to colonize the lymph node remains unclear. Terasaki et al. uncover that lymph node metastasis may be driven by an immune-to-cancer mitochondria transfer axis that impairs immune function and augments cancer immune evasion programs through type I interferon signaling.

Online now: Mitochondrial transfer from immune to tumor cells enables lymph node metastasis

Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier CRISPR-based tools can’t easily access the DNA in these organelles, but researchers are finding other ways in.

Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier.

CRISPR-based tools can’t easily access the DNA in these organelles, but researchers are finding other ways in

www.nature.com/articles/d41...

New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦

Structural insights into DdCBE in action enable high-precision mitochondrial DNA editing Based on cryo-EM structures of functioning DdCBE, Xiang et al. developed a model to guide TALE-recognition region and spacer length design. Application of the model and an engineered editor with a 2–3...

Structural insights into DdCBE in action enable high-precision mitochondrial DNA editing

www.cell.com/molecular-ce...

Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells Somatic mtDNA mutations undergo positive selection, shaping cell fitness and contributing to functional heterogeneity.

Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells
www.science.org/doi/full/10....

Nuclear mitochondrial DNA transfer revisited: From genomic noise to hallmark of aging Nuclear insertions of mitochondrial DNA (mtDNA) segments (NUMTs) represent an evolutionarily conserved phenomenon originating from the ancient endosym…

Nuclear mitochondrial DNA transfer revisited: From genomic noise to hallmark of aging
www.sciencedirect.com/science/arti...

Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations Somatically acquired mitochondrial DNA mutations accumulate with age, but the mechanisms and consequences are poorly understood. Here we show that transient injuries induce a burst of persistent mtDNA...

Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations | Science www.science.org/doi/10.1126/...

Mitochondria protect against an intracellular pathogen by restricting access to folate As major consumers of cellular metabolites, mitochondria are poised to compete with invading microbes for the nutrients that they need to grow. Whether cells exploit mitochondrial metabolism to protec...

Mitochondria protect against an intracellular pathogen by restricting access to folate

www.science.org/doi/10.1126/...

Mitochondrial origins of the pressure to sleep - Nature Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

“A mitochondrial electron surplus induces sleep”

Mitochondrial origins of the pressure to sleep www.nature.com/articles/s41...

A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....

Thanks for citing HaploGrep 2!

Selfish mutations promote age-associated erosion of mtDNA integrity in mammals - Nature Communications Mutations in mtDNA contribute to mitochondrial disease and aging only if they rise in abundance. Here, the authors show that deleterious mutations reach high abundance by hitchhiking on genomes that h...

Selfish mutations promote age-associated erosion of mtDNA integrity in mammals
www.nature.com/articles/s41...

Donor genetics and storage conditions influence mitochondrial DNA and extracellular vesicle levels in RBC units insight.jci.org/articles/vie...

Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood One of the strongest signatures of aging is an accumulation of mutant mitochondrial DNA (mtDNA) heteroplasmy. Here we investigate the mechanism underlying this phenomenon by calling mtDNA sequence, ab...

Exciting preprint from @rahulg603.bsky.social and colleagues!

Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood
www.biorxiv.org/content/10.1...

The Hidden Social Lives of Mitochondria When these energy-giving organelles thrive, so do we

Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell

great work by Martin Picard

www.scientificamerican.com/article/why-...

Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat? Human DNA is unavoidably present in metagenomic analyses of human microbiomes. While current protocols remove human DNA before submission to public repositories, mitochondrial DNA (mtDNA) has been ove...

🥁 NEW:

Commentary in @cellcellpress.bsky.social!

by @msabrysarhan.bsky.social Giacomo Antonello @whansi.bsky.social @cengoni.bsky.social @dmascalzoni.bsky.social @leviwaldron1.bsky.social Nicola Segata, Christian Fuchsberger

www.cell.com/cell/fulltex...

1/4

#microbiome #genomics #mitochondrialdna #openscience #cellpress #genetics | Christian Fuchsberger 🚀 Good start to the day, our research, "Human Mitochondrial DNA in Public Metagenomes: Opportunity or Privacy Threat?", has been published in Cell. We explore an important issue in research ...

for those on LinkedIn - Christian Fuchsberger wrote a great summary here:

www.linkedin.com/posts/christ...

Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat? Human DNA is unavoidably present in metagenomic analyses of human microbiomes. While current protocols remove human DNA before submission to public repositories, mitochondrial DNA (mtDNA) has been ove...

Exciting news! Our commentary is finally out, cudos to the team at EURAC (BZ) and CIBIO (TN) 👏

Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat? www.cell.com/cell/fulltex...

Mitochondria – the CEO of the cell Summary: In light of research advances recognizing the roles mitochondria play in directing cellular processes and behaviors, we propose reframing mitochondria as the chief executive organelle of the ...

Mitochondria – the CEO of the cell
journals.biologists.com/jcs/article-...

Mitochondrial DNA disease discovery through evaluation of genotype and phenotype data: The Solve-RD experience Exome and genome reanalysis from the Solve-RD cohort done with an automated mtDNA-filtering pipeline and MitoPhen-based HPO phenotype similarity scoring uncovered previously undiagnosed mtDNA variants...

Mitochondrial DNA disease discovery through evaluation of genotype and phenotype data: The Solve-RD experience

www.cell.com/ajhg/fulltex...

First map of human brain mitochondria is ‘groundbreaking’ achievement Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

The brain’s energy landscape as a potential window into brain health
www.nature.com/articles/d41...

(study led by Martin Picard and Michel Thiebaut de Schotten)

Mitochondrial DNA signals driving immune responses: Why, How, Where? - Cell Communication and Signaling There has been a recent expansion in our understanding of DNA-sensing mechanisms. Mitochondrial dysfunction, oxidative and proteostatic stresses, instability and impaired disposal of nucleoids cause t...

Mitochondrial DNA signals driving immune responses: Why, How, Where?
biosignaling.biomedcentral.com/articles/10....

Mitochondrial transplantation: Triumphs, challenges, and impacts on nuclear genome remodelling Mitochondria are membrane-bound organelles of eukaryotic cells that play crucial roles in cell functioning and homeostasis, including ATP generation f…

Mitochondrial transplantation: Triumphs, challenges, and impacts on nuclear genome remodelling

www.sciencedirect.com/science/arti...

Not really my announcement to make--I am but a lesser co-author--but IQ-TREE 3 has just been released!

(Most credit to Minh Bui and @roblanfear.bsky.social and their labs)

ecoevorxiv.org/repository/v...

Cells are swapping their mitochondria. What does this mean for our health? Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

Cells are swapping their mitochondria. What does this mean for our health?

www.nature.com/articles/d41...

Small molecules restore mutant mitochondrial DNA polymerase activity - Nature An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.

Small molecules restore mutant mitochondrial DNA polymerase activity
www.nature.com/articles/s41...