Dual Redox Behavior of Mitochondria‐Targeting Antioxidant: Prooxidant Activity Through Light‐Induced Redox Active Triplet State In mammalian cells, mitochondria targeting charge neutral molecule (compound 1) shows antioxidant properties in dark but becomes prooxidant in presence of visible light to induce apoptosis. Mechanist....

doi.org/10.1002/ceur...

Potent Preorganized Pyrazolidine Cyclophilin D Inhibitors Prevent Mitochondrial and Organ Injury in a Mouse Pancreatitis Disease Model Cyclophilin D inhibitors that prevent opening of the mitochondrial permeability transition pore (MPTP) are potential treatments for a range of acute and chronic diseases, including acute pancreatitis....

doi.org/10.1021/acs....

Newly discovered cellular trigger could lead to possible therapies for Parkinson's disease Autophagy is essentially the "rubbish collection" of our cells. If there are problems in this process, which is so important for our health, diseases such as Parkinson's can result.

A newly identified cellular pathway involving WIPI proteins offers fresh insight into mitophagy, suggesting new directions for targeted Parkinson’s disease therapies. doi.org/g9t998

Researchers discover new way cells protect themselves from damage An international research team has uncovered a surprising way compartments within cells work together to defend themselves against oxidative stress, a finding that could shift how we understand age-associated conditions such as diabetes and neurodegenerative diseases.

A newly identified mechanism shows mitochondria and peroxisomes cooperate to manage oxidative stress, offering fresh insight into cellular defense and potential targets for age-related disease therapies. doi.org/g9ssj9

Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities.

Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis

https://go.nature.com/46c474I

Amazing! Would be interesting to know how these phagosomes containing chloroplast did not fuse with lysosomes.

Thank you @iycnglobal.bsky.social
for the grant award. I would also like to thank Prof. G. Mugesh for supporting my grant application.

Imaging 3D cell cultures with optical microscopy - Nature Methods This Review discusses current 2D and 3D microscopy methods for imaging three-dimensional cell cultures and emerging strategies to address key challenges.

www.nature.com/articles/s41...

Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences Bidirectional transfer of mitochondria between cancer and immune cells.

The bidirectional transfer of mitochondria between cancer and immune cells is a newly discovered mechanism that thwarts anticancer defences

https://go.nature.com/3PNuEfh

Congratulations to Prof. Madhav Gadgil, the true Earth champion. I am from the Western Ghats and travel through them every vacation to reach my village. I am always thankful for your efforts!

A mechanism for why durable weight loss is so difficult: epigenetic memory of fat cells
www.nature.com/articles/s41...

A new kind of mitochondria YouTube video by nature video

New research in Nature showing mitochondria can split into two different forms resolves a longstanding mystery of how mitochondria can simultaneously provide cells with energy and essential building blocks, even when resources are limited. go.nature.com/40LeBW3 🧪