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Posts by Christopher Whyte

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Integrated information theory: the good, the bad and the misunderstood The integrated information theory of consciousness (IIT) is uniquely ambitious in proposing a mathematical formula, derived from apparently fundamental properties of conscious experience, to describe ...

🎉 📜 NEW #PREPRINT !! 📜 🎉

Spearheaded by Adam Barrett we tried to tackle some of the challenges of IIT.

We confront aspects worth delving into, with an incredible team of collaborators, inc. Pedro Mediano, @frosas.bsky.social, Daniel Bor, Lionel Barnett, and @anilseth.bsky.social.

1 week ago 17 11 3 0

If you need a method to infer causality from neural data, even when the signal is short, check our recent paper:

Paper: joss.theoj.org/papers/10.21...
Code: github.com/CMC-lab/Tran...

2 weeks ago 50 22 0 1
Schematic of theta waves and gamma packets recorded from the mouse visual cortex

Schematic of theta waves and gamma packets recorded from the mouse visual cortex

How does the visual cortex coordinate neural activity over spatial and temporal scales? We found broad θ waves organize local γ bursts and spiking, forming a flexible spatiotemporal code to multiplex feedforward/feedback signals. Now out in full @natcomms.nature.com: doi.org/10.1038/s414... 🧵

4 weeks ago 34 12 2 0

I've been inspired to become a founder of a new startup that develops brain-to-brain interface technology. It's called Talk. We're going to reinvent communication for the digital age.

The best part is that we're able to zero-shot transfer the full computational stack already used by your brain!

2 months ago 104 7 6 1
Nine subcortical/cerebellar atlases included in the subcortex_visualization Python package (and subcortexVisualizationR package in R). The atlases are depicted in two-dimensional vector graphic format.

Nine subcortical/cerebellar atlases included in the subcortex_visualization Python package (and subcortexVisualizationR package in R). The atlases are depicted in two-dimensional vector graphic format.

The extended version of my thesis procrastination project/subcortex visualization package is out now in both Python and R, now that I’ve graduated 🤠 This figure shows the 9 atlases included (and counting)!

Preprint: www.biorxiv.org/content/10.6...
Website: anniegbryant.github.io/subcortex_vi...

2 months ago 115 46 3 6
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BBC Radio 4 - What Is Quantum? Marnie Chesterton travels to the birthplace of quantum theory armed with just one question

Finally, after much delay from the BBC, Marnie Chesterton's "What Is Quantum?" is being broadcast at 9.30 am on Radio 4 on Tues 30th Dec. Recorded on Helgoland in the summer, with input from the leading figures in quantum mechanics (and me).
www.bbc.co.uk/programmes/m...

3 months ago 48 15 0 4

Really hoping bifurcations are the new manifolds. What a time to be alive 🥲

5 months ago 54 5 4 0
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1/ "Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans" - out now in @plosbiology.org, led by Michele Colombo, Jacopo Favaro, & Marcello Massimini. 🧠

6 months ago 23 9 1 0
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A Minimal Physiological Model of Perceptual Suppression and Breakthrough in Visual Rivalry Visual rivalry paradigms provide a powerful tool for probing the mechanisms of visual awareness and perceptual suppression. While the dynamics and determinants of perceptual switches in visual rivalry...

This was a whole lot of fun. The paper is unapologetically nerdy (even by vision science standards), and it was also a dream come true to work with Hugh Wilson extending his model to a new domain.

The first paper in the series ⬇️

www.biorxiv.org/content/10.1...

6 months ago 3 0 0 0
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TLDR?

We derive a closed-form expression for the hysteretic difference between contrast thresholds for awareness and suppression, and test a prediction of the expression in human psychophysical data.

2/3

6 months ago 0 0 1 0
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A Minimal Quantitative Model of Perceptual Suppression and Breakthrough in Visual Rivalry When conflicting images are presented to either eye, binocular fusion is disrupted. Rather than experiencing a blend of both percepts, often only one eye's image is experienced, whilst the other is su...

The final paper of my PhD is now out as a preprint. This is a follow-up piece in series of two companion papers modelling awareness and suppression in a new variant of continuous flash suppression.

arxiv.org/abs/2510.17154

🧵 1/3

6 months ago 16 5 1 0
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What changes and what stays the same as you scale from single neurons up to local populations of neurons up to whole brains?

Michael and Mac @macshine.bsky.social on the systems approach to study brains across scales.

braininspired.co/podcast/220/

7 months ago 23 8 0 0

Thank you so much for having me!! I always have a blast chatting with @bethfisher.bsky.social and this time was no different! 💕 Also I loved your reflections in the end and how both of you have change your mind perhaps a bit through sharing your experiences with each other. So cool and precious!

7 months ago 14 5 1 0
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Integrated information and predictive processing theories of consciousness: An adversarial collaborative review As neuroscientific theories of consciousness continue to proliferate, the need to assess their similarities and differences -- as well as their predictive and explanatory power -- becomes ever more pr...

The first major output of the @templetonworld.bsky.social @arc-intrepid.bsky.social adversarial collaboration testing IIT & predictive processing theories of consciousness is out now

arxiv.org/abs/2509.00555

7 months ago 40 17 1 3
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Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level).

If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...

7 months ago 57 25 3 0

OHBM Oz rego + abstracts now open. Get amongst it!

7 months ago 8 3 0 0
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Theoretical neuroscience has room to grow Nature Reviews Neuroscience - The goal of theoretical neuroscience is to uncover principles of neural computation through careful design and interpretation of mathematical models. Here, I examine...

I wrote a Comment on neurotheory, and now you can read it!

Some thoughts on where neurotheory has and has not taken root within the neuroscience community, how it has shaped those subfields, and where we theorists might look next for fresh adventures.

www.nature.com/articles/s41...

8 months ago 151 52 8 3

It’s touching and wonderful the amount of people saying reading Pratchett has made them a better person, myself included.

Was it @adamchapman.bsky.social I remembering saying that his downstream positive effect on UK society is something we should increasingly be considering as his readers age?

8 months ago 54 8 1 0
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🎊Ain’t no party like a thesis submission party🎊

Honored to have submitted my PhD as a recipient of the Paulette Isabel Jones Career Development Award from The University of Sydney!

Thank you x1000000 to MVP supervisor @bendfulcher.bsky.social & co-supervisor @macshine.bsky.social 😊

8 months ago 22 2 2 0

I need some help from the #neuroskyence Bluesky-verse. Anyone know the source of this ~quote from Walter J. Freeman Jr.: "the secrets of the brain are hidden by two of God’s own firewalls: neurobiology and non-linear dynamics". I read it yrs ago but can't seem to find my way back to the source.

8 months ago 13 4 5 0

Position open for a neuroimaging focused postdoc to come work with us in Sydney

Feel free to get in touch for a chat if you have any questions about it :)

usyd.wd105.myworkdayjobs.com/en-GB/USYD_E...

8 months ago 56 50 1 0
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Interested in cortical wave dynamics? Check out our new preprint led by J Cruddas with @jchrispang.bsky.social where review the physics and physiology of cortical waves and their implications for psychological function:

osf.io/preprints/ps...

@nsb-lab.bsky.social

8 months ago 70 24 1 0
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The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex - Nature Neuroscience This study maps the connections of layer 5 pyramidal neurons in the mouse cortex, revealing distinct local and intercortical wiring patterns, and provides an open framework for exploring the connectiv...

New electron microscopy study in @nature.com Neuroscience finds that layer 5 ET neurons mostly connect to inhibitory cells locally, esp. those suppressing other excitatory cells, suggesting a "winner-take-all" system.

🧠📈 www.nature.com/articles/s41...

8 months ago 33 8 1 0
OSF

After five years of confused staring at Greek letters, it is my absolute pleasure to finally share our (with @smfleming.bsky.social) computational model of mental imagery and reality monitoring: Perceptual Reality Monitoring as Higher-Order inference on Sensory Precision ✨
osf.io/preprints/ps...

8 months ago 129 35 4 4
moritz kriegleder presenting a slide on the current state of consciousness science

moritz kriegleder presenting a slide on the current state of consciousness science

finally recovered from all the thought provoking discussions I had at @assc28.bsky.social! presented a meta analysis of the current state of consciousness science and why we should leave theory convergence behind (based on work with @mnoichl.bsky.social & @niccolonegro.bsky.social)

9 months ago 15 2 2 0
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Dynamical independence reveals anaesthetic specific fragmentation of emergent structure in neural dynamics Conscious experience depends on the coordinated activity of neural processes that span multiple scales--from synapses to whole-brain dynamics. A recently introduced measure, dynamical independence, id...

📜🪇[PUBLISHED]: NEW PREPRINT!🪇📜

I am incredibly excited to announce that we have published our paper on how "Dynamical independence reveals anaesthetic specific fragmentation of emergent structure in neural dynamics"
w@thomasandrillon.bsky.social @anilseth.bsky.social Barnett, Carter

Strap in!
1/n

9 months ago 40 17 3 5
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A new study led by @timothysit.bsky.social reveals that different layers of mouse V1 integrate visual and non-visual signals differently.

Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries.
www.biorxiv.org/content/10.1...

9 months ago 72 19 0 2

New paper!

We introduce an efficient set of statistical features for fMRI time series (calibrated on mouse manipulation experiments and tested on mouse and human data): catchaMouse16.

Paper: doi.org/10.52294/001...

Code (python/Matlab/C): github.com/DynamicsAndN...

9 months ago 27 16 0 1
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Cooperative thalamocortical circuit mechanism for sensory prediction errors - Nature Experiments in mice show that a cortico-thalamic circuit generates prediction-error signals in primary visual cortex that amplify visual input that deviates from animals’ expectations.

Pairs well with www.nature.com/articles/s41...

“Our results indicate that individual V1 neurons do not signal how the actual visual input deviates from the animal’s predictions, as postulated within the predictive coding framework”

Thrilling to see a major theory get tested!

9 months ago 57 11 3 1
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Sensory responses of visual cortical neurons are not prediction errors Predictive coding is theorized to be a ubiquitous cortical process to explain sensory responses. It asserts that the brain continuously predicts sensory information and imposes those predictions on lo...

1/3) This may be a very important paper, it suggests that there are no prediction error encoding neurons in sensory areas of cortex:

www.biorxiv.org/content/10.1...

I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.

But...

🧠📈 🧪

9 months ago 220 79 13 5