Finally published. Many thanks to a wonderful collaborative team and scientific platforms!!! And thanks to editors and reviewers for enthusiasm and a great review.

www.nature.com/articles/s41...

Each publication in a #Microbio26 journal helps fund 4 student travel grants. Please publish with us if you can!

Ah this is great news Phil, I’m delighted for you to see this out!!

Implications for methenamine hippurate use in recurrent urinary tract infection management: Formaldehyde resistance and altered urinary composition Author summary The mainstay of treatment for urinary tract infections is short course antibiotics, often sufficient to clear the infection. However, a significant proportion of UTIs are recurrent, lea...

So my last publication is out! From a clincial trial for a treatment that was argued could not lead to bacterial resistance, uro-associated bacterial isolates were found to be resistant and we show genetically how. Thanks to Chris Harding and Frank Sargent

journals.plos.org/plospathogen...

Expanding the LuxR-type receptor functional repertoire: Protein-protein interactions in quorum sensing regulation Quorum sensing (QS) enables bacteria to coordinate gene expression in response to population density, with LuxR-type transcription factors playing a central role in this process for many Gram-negative...

A true labor of love for @calebmallery.bsky.social is out now in PLOS Pathogens: a review article where we highlight current and emerging examples of key protein-protein interactions with LuxR-type receptors that control community behaviors and pathogenesis.
journals.plos.org/plospathogen...

Phages communicate across species to shape microbial ecosystems Gallego-del-Sol et al. show that arbitrium-coding phages can sense non-cognate peptide signals from other phages to regulate lysis-lysogeny decisions. This crosstalk affects lysis-lysogeny outcomes of...

This paper started as an idea @albertomarina.bsky.social had many years ago… which of course means he was right all along 😄. Some of us just needed a few years (and a lot of experiments) to catch up.
Grateful (and slightly humbled) to be part of this. Thanks Alberto!
www.cell.com/cell/fulltex...

Fabulous opportunity

Unbelievably proud of the work that everyone has put into this paper. Really grateful for such fab colleagues! Mycobacteria continue to be (subjectively) the most interesting bacteria 🤭

We've been we've been working on this for quite a while now (hopefully published soon). Grateful to @proftracypalmer.bsky.social for concinving me & @lislowe.bsky.social that mycobacteria produce inter-bacterial toxins. Team science, led by @sambenedict5.bsky.social www.biorxiv.org/content/10.6...

Well done team, I know how hard you have all worked on this!!!

All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy?

Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation.

www.nature.com/articles/s41...

(1 out of 3)

Research Fellow (Postdoctoral) at University of Birmingham Explore an exciting academic career as a Research Fellow (Postdoctoral). Don't miss out on other academic jobs. Click to apply and explore more opportunities.

Two post-doctoral positions open in our lab. We're looking for people with expertise in molecular microbiology and/or genome-scale tools. Initially 3 yrs, posts could be extended for upto 8 yrs. If you'd like to know more about us take a look at www.graingerlab.com

www.jobs.ac.uk/job/DQY475/r...

Pseudomonas aeruginosa dynamically prioritizes motility and resource recycling during prolonged starvation | mSystems Molecular microbiology has traditionally focused on exponential growth in model organisms as the preferred context in which to study bacterial physiology, especially the regulation of new protein synt...

Now out in its final form, our investigation of how Pseudomonas aeruginosa manages resources to permit ongoing adaptations to environment during starvation:
journals.asm.org/doi/10.1128/... Congrats to first author @findunmun1.bsky.social, and co-authors Claudia Hemsley and Elize Ambulte.

Image of the cover of the 1st volume of ISME Host Microbe a new official journal of the International Society for Microbial Ecology. Cover images shows a plant stomata with bacteria around and entering.

Excited to announce our new journal from @isme-microbes.bsky.social ISME Host Microbe is live and now accepting submissions. Look forward to receiving your papers! #Microsky 🧫 🦠

Here we show that buildup of uremic toxins during CKD generates nitrate in the colon. Nitrate supports expansion of Enterobacteriaceae, turning them into a major source of uremic toxins. Inhibiting nitrate production (iNOS inhibition) mitigates disease progression. www.science.org/eprint/YGNMK...

The glucose uptake inhibitor SgrS is induced by D-serine yet does not contribute to growth arrest in enterohaemorrhagic Escherichia coli Bacterial pathogens sense and respond to host-derived metabolites to regulate virulence and establish successful infections. d-Serine, an amino acid abundant in some extraintestinal environments but s...

Delighted to share the hard work of undergraduate student Ella Rellis and first publication from my group since relocating to TCD. Here we identify a new stress response regulator induced by D-serine. 🦠🔬🧫 @microbiologysociety.org #publishforthecommunity www.microbiologyresearch.org/content/jour...

Absolutely delighted to see this out! Huge congrats to all involved, especially @pathonick.bsky.social and @drandyjroe.bsky.social for keeping the d-serine saga going!

Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids - Nature Microbiology Clostridium perfringens lacking perfringolysin O toxin isolated from preterm infants metabolizes human milk oligosaccharide disialyllacto-N-tetraose to produce metabolites that promote the growth of c...

🚨 A new piece of the preterm gut microbiome puzzle just fell into place!

Bifidobacterium metabolise human milk oligosaccharides (HMOs) in early life — shaping immunity, supporting gut development, and protecting against diseases like necrotising enterocolitis (NEC).

www.nature.com/articles/s41...

non-correlating mRNA-protein levels during stress 🦠

Great talk from @hobbslabmicro.bsky.social - thank you for visiting @mhd-newcastle.bsky.social and telling us why antibiotic tolerance is so important

Another brilliant opportunity to work the fantastic Andreas in St Andrews!

Unraveling posttranscriptional regulatory networks in phage infection Phages employ sophisticated transcriptional regulatory networks to optimize replication. Recently, Silverman et al. used RIL-seq (RNA interaction by l…

Like bacteria, phages use sRNAs to regulate gene expression! Out today in @cp-trendsmicrobiol.bsky.social, @mvelascogomariz.bsky.social and I highlight a recent RIL-seq study from the @saharmelamed.bsky.social lab that looked into posttranscriptional regulation of lambda!

tinyurl.com/lambda-RIL-seq

Last chance to apply for this exciting PhD with us. Deadline tomorrow the 27th of February!

Superb opportunity to learn from one of the smartest scientists I know. And a lovely place to live so what’s not to like! Apply now!

Early bird registration for VTEC 2026 ends this Friday (February 27th). Please share with your networks and consider registering for this great One-health conference covering all topics VTEC related, taking place in Aberdeen on the 10-13th of May.

Loss of Fsr quorum sensing promotes biofilm formation and worsens outcomes in enterococcal infective endocarditis - Nature Communications Infective endocarditis (IE) is an understudied biofilm-associated infection. Here, analyses of preclinical and clinical data reveal that the Fsr quorum sensing (QS) system of Enterococcus faecalis is ...

What if quorum sensing doesn’t promote biofilms - but restrains it? 🤔

New work from @harisantypas.bsky.social shows that the Fsr QS system in Enterococcus faecalis acts as a brake on biofilm formation and pathogenesis during infective endocarditis (IE).

www.nature.com/articles/s41...

Recurrent and chronic UTIs have a huge impact on patient's quality of life and is an area of research which is often overlooked and understudied. There are massive gaps in our understanding which we can fill to... (1/3)

See all images in this post and that follow for the top 10!

#MicroSky #UTISky

Mechanism and reconstitution of circadian transcription in cyanobacteria - Nature Structural & Molecular Biology Fang et al. reveal how a bacterial circadian clock turns genes on and off at the right times of day and use the purified proteins to drive circadian gene transcription in a test tube for days.

Mechanism and reconstitution of circadian transcription in cyanobacteria

in @natsmb.nature.com by Mingxu Fang et al from Sudan Golden @kevincorbett.bsky.social Yulia Yuzenkova

www.nature.com/articles/s41...

Bidirectional promoters in Escherichia coli: regulatory rules and implications for gene expression noise Abstract. In prokaryotes, bidirectional promoters are pseudo-symmetrical DNA sequences that stimulate divergent transcription. Ubiquitous, and far more lik

@ewarman.bsky.social has followed up on her discovery of bidirectional promoters in bacteria by defining their basic rules for regulation and links to gene expression noise...

academic.oup.com/nar/article/...