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Posts by April Hayes

Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.

2 days ago 1532 434 16 43
Mechanistic insights into plasmid transfer inhibition in Enterobacterales by nucleoside analogues - npj Antimicrobials and Resistance npj Antimicrobials and Resistance - Mechanistic insights into plasmid transfer inhibition in Enterobacterales by nucleoside analogues

My main postdoc paper is now out in @natureportfolio.nature.com npj Antimicrobials and Resistance! www.nature.com/articles/s44.... Using flow cytometry, we show that the nucleoside analogues azidothymidine, didanosine, stavudine, and trifluridine reduced transfer of AMR plasmids pCT and pKpQIL (1/3)

1 week ago 44 12 1 0

LLMs are like your stoner friend who is a voracious reader. They have a lot of information in their brains, but it's not necessarily in the right order, and sometimes they talk utter nonsense.

1 week ago 6 1 0 0
myRSB: Me and the RSB

📢 Excited to be offering a Plant Health vacation studentship this summer on plant disease biocontrol and predatory bacteria! Supervised by me at Manchester Uni! @manchester.ac.uk

If interested—or know someone who might be—please share and apply! my.rsb.org.uk/services.php... 28th April deadline 🌿🍅🦠

3 weeks ago 4 3 0 1

would 100% recommend this as a PhD position to anyone interested in bacteria/temperature/amr. Dan is a great scientist to work with, and more importantly is a kind person who cares about people and (also) how science works

3 weeks ago 0 0 0 0
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New paper showing that bacteria with more genes for cooperation can live in a broader range of habitats and that genes for cooperation are more more likely to be in the accessory genome www.pnas.org/doi/10.1073/... @lauriebelch.bsky.social

1 month ago 70 33 2 0
Cover of Microbiology Outlooks featuring an article by Dr Damien Meyer on integrating game dynamics with within-host evolution genomics.

Cover of Microbiology Outlooks featuring an article by Dr Damien Meyer on integrating game dynamics with within-host evolution genomics.

Is virulence a fixed trait? This first commentary in Microbiology Outlooks considers why it may be better understood as a context-dependent evolutionary strategy. Discover the Open Access article: https://doi.org/10.1099/mout.0.00001

1 month ago 4 2 1 0

🚨 New preprint 🚨

How promiscuous really are conjugative plasmids, and what does that mean for plasmid co-occurrence?

A pleasure to collaborate with @craigmaclean.bsky.social on the first paper of my fellowship!

www.biorxiv.org/content/10.6...

2 months ago 30 11 0 0
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(President's Doctoral Scholar Award) A mechanistic understanding of microbe-immune cross talk in the face of pollutant challenge at The University of Manchester on FindAPhD.com PhD Project - (President's Doctoral Scholar Award) A mechanistic understanding of microbe-immune cross talk in the face of pollutant challenge at The University of Manchester, listed on FindAPhD.c...

📣 2026 PhD studentship 📣
Via @manchester.ac.uk 's President's Doctoral Scholar Awards, we are encouraging applications for a PhD on the effect of pollutant exposure on microbe-immune cross talk. This project will incorporate microbiology, immunology, & bioinformatics. Deadline: 16 March 2026!

2 months ago 7 6 0 2

He may have only barely known about bacteria, and not at all about viruses, but Darwin was right about hating an ill-defined species concept

2 months ago 40 4 1 2
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The Resistance-Nodulation-Division efflux pump EefABC is highly conserved within lineages of E. coli commonly associated with infection Resistance-nodulation-division (RND) efflux pumps confer multidrug resistance in Gram-negative bacteria and are critical for many physiological functions including virulence and biofilm formation. The...

The coolest finding of my PhD is finally out! E. coli has a 7th RND pump that is present in phylogroups B2/D/E/F but absent in A/B1/C. As a result EefABC has been absent in all K-12 RND studies! Co-authored by the very talented Dr. Lizzy Darby. @jessicamablair.bsky.social
doi.org/10.1099/mgen...

3 months ago 22 5 2 1
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Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation - Nature Genetics Population-based studies from Sweden with replication in Norway identify associations between host genetic variants and gut microbial composition and implicate short-chain fatty acid chemosensors as m...

Delighted to have contributed to this impressive work led by @tovefall.bsky.social & many others👏 (w/ @gazollavolpiano.bsky.social from our side). This novel microbiome GWAS (n=~16k+12k valid) expands knowledge on genetic factors associated w/ gut microbiota variation.
www.nature.com/articles/s41...

2 months ago 11 4 2 0
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Co-occurrence is associated with horizontal gene transfer across marine bacteria independent of phylogeny Abstract. Understanding the drivers and consequences of horizontal gene transfer (HGT) is a key goal of microbial evolution research. Although co-occurring

Now out & nicely formatted in @isme-microbes.bsky.social

A big analysis of ocean genomes & metagenomes co-led by former postdocs, now PIs, @gmdouglas.bsky.social & @cyanophage.bsky.social along with co-PIs @lbobay.bsky.social & Samuel Chaffron.

A few highlights... 🧵 (1/n)

doi.org/10.1093/isme...

2 months ago 78 38 2 0

I am pleased to share that our paper is now published in Cell!
www.cell.com/cell/fulltex...
I am deeply grateful to all co-authors for making this possible.

This work was made possible through the guidance of Dr. Peer Bork. I share this in grateful memory and with deep respect for his mentorship.

2 months ago 28 14 1 2
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(CODE M) Losing your head: how do bacterial viruses evolve into anti-competitor weapons? at The University of Manchester on FindAPhD.com PhD Project - (CODE M) Losing your head: how do bacterial viruses evolve into anti-competitor weapons? at The University of Manchester, listed on FindAPhD.com

🚨 PhD Studentship available! 🚨

We're hiring a UK student to start in Oct '26 via the BBSRC CODEM scheme. Full studentship plus £10k top-up PA. Study the mysterious ZOMBIE PHAGES 🧟 🦠 with our fabulous @mermanchester.bsky.social and @uommib.bsky.social communities!

www.findaphd.com/phds/project...

2 months ago 6 6 0 0
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At long last, my final PhD chapter is out: we developed a novel evolutionary simulator of bacterial pangenomes, Pansim, fitting it to data from >600K genomes using a likelihood-free framework, PopPUNK-mod, to explore neutral and adaptive pangenome dynamics www.biorxiv.org/content/10.6...

2 months ago 45 18 2 1
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Historical contingency limits adaptive diversification in a spatially structured environment Abstract. Understanding how genotype-by-environment (G × E) interactions influence evolutionary trajectories and contribute to historical contingency is ke

Historical contingency limits adaptive diversification in a spatially structured environment

@evolletters.bsky.social from @megbehri.bsky.social

academic.oup.com/evlett/artic...

2 months ago 13 4 0 0

New round of PhD studentships in microbial engineering, including one with me on engineering non-canonical DNA mismatch repair into E. coli 🦠🧬
www.findaphd.com/phds/project...

2 months ago 2 12 0 1

PhD projects in microbial engineering now up, including one with @whelanfj.bsky.social @willpjsmith.bsky.social and me! 🦠

www.findaphd.com/phds/project...

2 months ago 7 5 0 1
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Novel artificial selection method improves function of simulated microbial communities Author summary Artificial selection has been extremely powerful in improving properties of complex biological or biochemical entities. The most familiar examples come from the breeding of animals and ...

Thrilled to see this paper finally out! journals.plos.org/ploscompbiol... It was a difficult story to communicate and took us a while to get right. Big congratulations to @wbjorn.bsky.social, Pablo Guridi and Flora Arias-Sanchez!! And thank you the reviewers who helped improve it. Keep reading...

2 months ago 32 12 1 0
Optimising the use of alternative therapies for the treatment of urinary infections - The University of Nottingham

🚨 Fully‑funded PhD for Home Students🚨

We'll explore non-antibiotic alternatives in relatistic environments, uncovering how they work, if they affect antibiotic activity and whether they influcence AMR acquistion. Come join a wonderful supervisory team!

#MicroSky #UTISky #AMar

tinyurl.com/38u552bu

3 months ago 5 10 1 3
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How to lead a journal club you won’t be embarrassed by later One of the jobs facing an early-career scientist, and a developing writer, is to learn what their field’s literature looks like. One of the best tools to that end is the journal club. If you’ve nev…

It's easier to tear down than build up, and in science we have a bad case of that. So: how to lead a journal club that actually finds value in what you read. scientistseessquirre... 🧪

3 months ago 66 28 4 1
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"84.9% of colleagues on FTCs reported that their contracts had negative impacts upon their wellbeing"

^ As long as fixed-term contracts (FTC's) are the norm for early-career scholars + many others, then our workplaces are structurally screwing us.

3 months ago 4 1 1 0

There's still a few days left to apply for our AI-Intervene PhD project mapping the drivers of avian influenza using viral genomics, bird migration data and AI-powered phylodynamics.

Come join us! Details below.

#FindaPhD #LondonPhD #genomics

3 months ago 2 4 0 1
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Biased sampling driven by bacterial population structure confounds machine learning prediction of antimicrobial resistance Machine learning methods have emerged as promising tools to predict antimicrobial resistance (AMR) and uncover resistance determinants from genomic data. This study shows that sampling biases driven b...

Our preprint on predicting drug resistance in bacteria is now out in @plosbiology.org. We show ignoring phylogenetic structure in genome collections leads to overly optimistic evaluations of machine learning methods for AMR prediction. Work from @yanyingyu.bsky.social with @nwheeler443.bsky.social.

4 months ago 35 21 0 1

🦠🧫 a collaboration with the Institute for Tropical Medicine in Tübingen and CERMEL in Gabon @cmfi.bsky.social

4 months ago 5 5 1 0

Asexuality is a global identity.

That’s a major finding in a study I recently published with @francescorampazzo.com in Demographic Research.

Analyzing dating app data spanning 162 countries from over 900,000 users, we found that asexuality showed up in every age group and in every region.

4 months ago 70 29 2 1

MetaPointFinder:
A new approach for detecting mutation-driven antimicrobial resistance directly from metagenomic reads.
Fills a major gap in current resistome profiling by capturing chromosomal AMR mutations that metagenome tools miss.

github.com/aldertzomer/...

4 months ago 24 19 3 1
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We're excited to release metaTraits.embl.de! 🦠 Interactively explore 140+ 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗮𝗹 𝗽𝗵𝗲𝗻𝗼𝘁𝘆𝗽𝗶𝗰 𝘁𝗿𝗮𝗶𝘁𝘀, harmonized & integrated from culture-derived collections 🔬 & genome-based predictions 🧬 for >2M MAGs & genomes.

Publication at NAR: doi.org/10.1093/nar/... @narjournal.bsky.social #microsky 🧵 1/8

4 months ago 38 29 1 0

It’s not only medications—environmental chemicals can also inadvertently harm our gut microbes. Excited to have contributed a bit to this important study!

4 months ago 23 5 0 0