Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.

The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states!

Out today in Nature: rdcu.be/fdC2A

@uclbrainscience.bsky.social

two men are sitting on a couch talking to each other . one of the men is wearing a sweater . ALT: two men are sitting on a couch talking to each other . one of the men is wearing a sweater .

Three middle-aged white blokes chatting? You crazy beautiful bastard! That's genius!

OpenAI: We’re burning money like the Joker. A miracle needs to happen for us to turn a profit

Microsoft: Please please use our AI systems, we’re teetering on the edge here

Anthropic: I wonder what’ll kill us first: lawsuits, regulations or model collapse

Media and universities: AI is here to stay

Yes, do all that, and also start a podcast. Just far too few middle-aged centrist white blokes at the moment. You'll clean up.

Good chance he just goes off-script and veers into absolute blasphemy, and then afterwards Fox News has to pretend he was starting his own schismatic Church or something.

Diffusion MRI (dMRI) is a powerful tool to study white matter maturation. In our new preprint, we process and distribute a new resource of >24,000 ABCD dMRI scans using open source tools! We then evaluate how methods shape inferences about development.

🔗 www.biorxiv.org/content/10.6...

One of these things is not like the others. Poor Nora. 😢

a man applauds with the #schitts creek logo behind him ALT: a man applauds with the #schitts creek logo behind him

Outstanding. No notes. 10/10.

I mean, everything he touches turns to shit, so... 😬

Trump announces reforms to accelerate access to psychedelic drug treatments President signed executive order directing FDA to expedite review of psychedelic drugs including ibogaine

Very bad man does potentially good thing, likely for very bad reasons. Honestly not sure how to feel about this. 🤷‍♂️
www.theguardian.com/us-news/2026...

I'm Neuroskeptic!

(I'm really not.)

Brilliant. Also, I miss the old days on Twitter with people like Chris on there.

I asked ChatGPT who I am. It said I'm Chris Chambers.

I am not Prof. Chris Chambers, and I didn't reveal myself as Chris Chambers (or anyone else) in 2015...

I can see the logic in thinking that we're the same person, since we agree on a lot of things, but it's not true! And it gets worse...

An international mega-analysis of psychedelic drug effects on brain circuit function - Nature Medicine Analysis of neuroimaging datasets across five major psychedelics revealed a shared brain signature and provides a comprehensive insight into how these drugs reorganize brain architecture.

Now that it has been out for a week, I thought I’d address a few strange takes regarding our recent mega-analysis on the effects of psychedelics on brain function (specifically, resting-state functional connectivity). 1/15
www.nature.com/articles/s41...

Not once in the 80s, 90s or 00s do I recall a politician urging the public to embrace email, mobile phones, texting, two factor authentication, online banking, air fryers, or to replace all their cassette collection with a CD collection.

So forgive me if I smell a rat.

Still good news!

🚨It turns out that semaglutide, known to reduce food intake and obesity, causes rats to increase their food choices compared to cocaine!

This effect is particularly evident when the effort required to obtain cocaine is intermediate

www.nature.com/articles/s41...

I’m looking for an automated way to read others’s scientific data without giving credit or acknowledgement, and also claim full credit for insights from it. And I want it to have a fitting name

OAI: say no more

Professor of Neuroscience at University of Reading Apply for the Professor of Neuroscience role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.

📣 Job alert: We are recruiting a Prof in Neuroscience with MRI expertise to join us at @unirdg-cinn.bsky.social and @unirdg-psych.bsky.social. See tinyurl.com/2kdjph8v for details. Contact me for info/chat. Please spread the word

#neuroskyence #neurojobs

Sadly, applications to the Advanced Python summer school have dropped significantly over the past 2 years.

Plus, there'll be no external funding for the 1st time in *17 years*.

Likely all because of GenAI - but programming skills still matter🔥

Deadline May 3, please help by sharing:
aspp.school

Woo!

The Brexit delusion is dead – so now Keir Starmer doesn’t need to pretend any more | Rafael Behr To rebuild relations with Europe in a dangerous world, the prime minister needs to win big arguments, not hide behind outdated red lines, says Guardian columnist Rafael Behr

Brexit is an unpopular shitshow, global politics and priorities have changed and there’s now a majority of voters who’ve been resolutely scorned since the Brexit vote.
I dunno. Maybe tap into that demographic and see how you go. Or keep losing to Reform.
www.theguardian.com/commentisfre...

Fair enough, that's fairly normal here too, but even expecting a masters student to get a first-author paper is quite unusual.

God no. Are people really getting first-author papers as undergraduates? How does that even work? Would be extraordinarily unusual in the UK.

I'll be giving a talk on psychedelics & memory via Zoom tomorrow. You can register for it here:
open-foundation.org/events/onlin...

Unstoppable gobshite meets an infallible object.

Orban defeated: Good morning and goddamn it's a beautiful day All of a sudden, after months of total darkness, there is hope.

Good morning and goddamn it's a beautiful day iandunt.substack.com/p/orban-defe...