Continuous linezolid infusion: the new way to dose, the old risks to fear Abstract. Continuous infusion (CI) of linezolid has been proposed to stabilize exposure and improve pharmacokinetic/pharmacodynamic (PK/PD) target attainme

Pleased to share our new review in JAC:
Continuous linezolid infusion: the new way to dose, the old risks to fear

academic.oup.com/jac/article-...

EMCrit 413 - Translating Recent Sepsis Papers to the Bedside with PulmCrit (Farkas) Ok, new sepsis papers, but what should we actually do?

EMCrit 413 - Translating Recent Sepsis Papers to the Bedside with @PulmCrit (Farkas)
- Confounding Effects of Vasopressin
- Perfusion Index?
- Echo-Pressor-Echo
& so much more...
[#FOAMed for now]
emcrit.org/413

Trimethoprim-sulfamethoxazole carries a very low (but real) risk of causing ARDS.

Duration of therapy is a risk factor (>7 days).

Could likely be minimized by avoiding unnecessarily long courses.

TMP-SMX is usually well tolerated, but can wreak havok (SJS, ARDS, drug-induced meningitis). #EMIMCC

Patient with cirrhosis and INR of 3 needs a procedure

Please step away from the FFP

EVERY guideline & article agrees that FFP shouldn't be given for pre-procedure coag optimization (even high-risk procedures)

Plt & fibrinogen are more controversial

Discussion emcrit.org/ibcc/cirrhos... #EMIMCC