🔥 Late Breakers
SNAP platform RCT| Adjunctive Clindamycin in S.aureus bacteraemia
❌ No mortality benefit
90d mortality:16.9% vs 15.2% aOR 1.16 (CrI cross 1)
📊PPSup(~7%)→Futility threshold reached
⚠️ICU subgp:numerically worse with clinda
⚖️CDAD:no # (~2%)😯
#ESCMIDGlobal2026 #idsky
Very nicely written Tom! We should share this with the SNAP community.
Very interesting! We need to get funded for the RCT. @gurujosh.bsky.social
📣 New CLARITY articles by Erin McCreary, PharmD & Ahmad Mourad are out to help us understand the GAMECHANGER trial & #cefiderocol The first notes a mortality signal among metallo-β-lactamase–producing infections... #IDSky #clinmicro https://ow.ly/GAqx50Yq6uh
And @gurujosh.bsky.social and I just recorded a podcast with Scott Berry for 'In the Interim'. We discuss the SNAP journey so far. www.berryconsultants.com/resources/po....
Episode should drop in 2-3 weeks. Will post again when it does.
@thedohertyinst.bsky.social #IDSky
Just woke up and checked emails to see that 8 new participants recruited to #SNAP_Trial in the past 8 hours! While a number of domains have closed (PSSA, MSSA, adjunctive clindamycin) we continue to recruit to other domains. Beyond 5,800 total participants now.
@gurujosh.bsky.social
We were absolutely the beneficiaries of your visit @angelahuttner.bsky.social!
We learnt so much about scientific communication and publishing, gender equity in medicine and science, and UTIs! (each was the focus of a talk / discussion Angela led).
#IDSky
Still waiting for journals to accept the SNAP papers...
Also has been my interpretation.
Awesome to have @angelahuttner.bsky.social visiting in Australia!
I think you are probably right. But it feels like +FUBC for VGS/S anginosus would raise the ‘risk’ of endocarditis (compared to -FUBC). And would contribute to equivalent of a VISTA score for S aureus.
With ESCMID Global quickly approaching!
To help you spread the word and get involved, check out ESCMID Global 2026 Promotional Toolkit
The official hashtag for the congress this year is #ESCMIDGlobal2026 on all social media channels. #IDSky
www.escmid.org/congress-eve...
My top 10 ID papers for 2025. Full citations and descriptions available at clarityinitiative.org/hot-takes
Also see/hear our Communicable podcast episode on this at communicable.transistor.fm/episodes/com...
What were your top 10? Any thoughts about what I missed welcome!
#IDSky #Top10papers
Medical research spending has a positive return on investment; for every $ invested there's an estimated $4 return. Beyond economics, delays hold up medical innovations
Australians deserve better
If you agree, please sign the petition to let #auspol leaders know why medical research matters
#NHMRC
🎙️ Just published Communicable E45: Top infectious diseases papers in 2025
Hosted by Josh Davis & Emily McDonald w/ invited guest Steven Tong
Listen on #Communicable: https://share.transistor.fm/s/9e626f2a
#IDSky #clinmicro
📣 New #Communicable drops Mon 26 Jan! In our last episode, we brought you some favorite #clinmicro papers of 2025. We continue this thread in our next episode with top ID papers of 2025, picked by our editors, Josh Davis & Emily McDonald and guest, Steven Tong. ⭐ Tune in Monday🎙️
#IDSky
C gattii?
Great to see this paper and editorial! Convincing for HIV and C neoformans.
Where is the field regarding non HIV patients? And also C gattii meningitis? Are there trials being conducted in these populations?
We're going to randomise patients in SNAP to: 1) clopidogrel vs no clopidogrel (CLOPIDO SNAP #1) and; 2) aspirin vs clopidogrel for those already on aspirin (CLOPIDO SNAP #2).
💊Drug Hypesensitivity Symposium 2026 - #DHS2026
Registrations are now open for our amazing 3-day #drugallergy & #antibioticallergy program in Melbourne 23-25th October 2026.
Stellar international🌏speaker lineup. @allergy-eaaci.bsky.social @thedohertyinst.bsky.social
➡️https://dhs2026.org/
Agree. It's a short, well researched, and strangely moving book. Well worth reading.
I see patients with TB every week. I can access modern diagnostics and treatments. Reading this book reminded me that is not the case in much of the world.
TB kills 1.25 million per year.
A disease of injustice.
Everything Is Tuberculosis: John Green www.goodreads.com/book/show/22...
We are genotyping and phenotyping as many of the isolates as we can get hold of (will be most). So the analysis of blaZ and cefazolin inoculum effect will follow once done. Can't wait to see what this shows!
Altogether there were 1341 participants in SNAP, so much larger than CloCeBa.
Saw the post on X also - but I've decided today to deactivate my X account!
Agree with others that the numbers are too small in CloCeBa to draw strong conclusions.
Across the board in SNAP, cefazolin was better (15% mortality vs 17%). Similar in the 100 odd patients with endocarditis.
Exciting news - there's a spot open in the #IDepi team at @thekidsau.bsky.social !
Prof Chris Blyth is looking for a Research Officer to work on influenza research
1-year initial contract based in Perth
Slight bias (my team/boss) but it's a fantastic opportunity!
#EpiSky #AcademicSky #AusAcademia
Now I'll have a look at how Covid-19 deaths have changed over time.
See the quoted thread for discussion of how cases, emergency department visits, and hospitalizations have changed over time.
1/
That's a pretty cool idea!
Laurens Manning has done some of the research with antibodies. Suggests that SDSE is the predominant cause of lower limb cellulitis!
academic.oup.com/ofid/article...
Ouli’s a clinician who developed incredible bioinformatics and coding skills. Plus the smarts to use those skills to communicate ideas
Pretty cool that Robin Patel picks Ouli Xie's @lancetmicrobe.bsky.social paper on SDSE and S pyogenes as one of her top 3 clinical microbiology papers for 2025! As expected, Robin does a great job explaining the paper.
www.thelancet.com/journals/lan...
@onisillos.bsky.social
The other thing that hasn't been well measured is secondary GAS infections (that are not 'invasive'). Possible that some of these are prevented.