All positions are part of the @maxplanck.de
#Postdoc Program — competitive pay, world-class environment, international community. Don't miss out! postdocprogram.mpg.de/all-postdoc-...

3/3 Mass Spectrometry-Based Proteomics Postdoc — work at the cutting edge of MS-based biology in one of the world's leading proteomics groups! Apply → postdocprogram.mpg.de/node/43386
#MassSpec #PostDoc #Parkinson

2/3 Computational Postdoc in Multi-Omics Data Integration — if you speak protein & beyond, we want you in Munich! Apply → postdocprogram.mpg.de/node/43387
#MultiOmics #PostDoc #Parkinson

1/3 Computational Omics Scientist — join us in building the AlphaX Proteomics Software Ecosystem. Code meets biology at scale! Apply →
postdocprogram.mpg.de/node/43388
#Proteomics #PostDoc

We are hiring! The Matthias Mann Lab @mannlab.bsky.social @mpibiochem.bsky.social in Munich has 3 exciting #postdoc openings in proteomics & computational biology. #MSProteomics #PostDoc
postdocprogram.mpg.de

2026 Canada Gairdner Award Winners Announced 2026 Canada Gairdner Awards recognize world-leading scientists for breakthrough discoveries advancing human health.

Congratulations to all laureates and a big shout out to fellow Max Planck Director Wolfgang Baumeister, also among the 2026 recipients — Big Day for @mpibiochem.bsky.social
Incredible science being celebrated. #Gairdner2026
www.gairdner.org/resource-hub...

Big day for proteomics and in good company! Matthias Mann @mannlab.bsky.social @mpibiochem.bsky.social, John Yates and Ruedi Aebersold receive the 2026 GairdnerAwards for transforming how we measure and understand proteins at scale. #SystemsBiology #Proteomics #Gairdner2026

Postdoc in Computational Spatial Proteomics and Multiomics Integration - Vacancy at Aarhus University Vacancy at Department of Biomedicine - Forsk. & udd., Skou-bygningen, Aarhus University

Exciting opportunity — if you are exploring your next move, check it out and apply!
health.au.dk/en/about-hea...

The Catalyst One of <em>Literary Hub</em>'s Most Anticipated Books of 2024<br /><br />&#8220;Lively and entertaining.&hellip; Biology will never be the same.&#8221; &#8212;Adrian Woolfson, <em>Wall Street Journal<...

wwnorton.com/books/978132...

The legendary Tom Cech delivered a masterful distinguished lecture @mpibiochem.bsky.social on how RNA controls DNA. The audience was captivated! Tom's infectious energy, humility and groundbreaking science continue to inspire us all. Thanks so much for your memorable visit!

Characterizing the ZenoTOF 8600 in collaboration
@sciex.bsky.social . Scanning DIA on a compact platform — ~10K protein groups in bulk to single-cell proteomics & Parkinson's-relevant phosphosite detection with complementary CID & EAD fragmentation.
biorxiv.org/content/10.64898/2026.03.12.711261v1

Congratulations to first author Jakob Bader and thanks to our wonderful collaborators Bernhard Hemmer, Christiane Gasperi @tum.de and the entire team!

Beyond diagnosis, the CSF proteome at diagnosis informs disability progression and disease course evolution years later — a major unmet need in MS. At ~2,000 proteins per sample, proteomics is becoming a powerful engine for biomarker discovery in neurology, for MS and beyond.

For multiple sclerosis, we focused on the ~10% of patients lacking oligoclonal bands, where diagnosis is hardest. Our 22-protein panel outperforms current CSF parameters for differential diagnosis from other inflammatory CNS diseases — validated with a targeted assay.

Now in @cellpress.bsky.social: We profiled cerebrospinal fluid proteomes from 5,000 neurology patients by mass spectrometry — mapping protein changes across stroke, brain cancer, infections & autoimmune diseases, revealing shared and disease-specific signatures.
www.sciencedirect.com/science/arti...

6/
Curious to see where the combination of single-cell resolution and spatial context in proteomics will take us next! Congrats to @carolineweiss.bsky.social , @poratshliomlab.bsky.social and team at the NCI and Karsten Borgwardt and team @mpibiochem.bsky.social

5/
We also examined liver tissue with disrupted architecture (desmoplasia). Protein zonation is globally reduced, but pericentral proteins are hit hardest. Only 11.6% maintained their zonation vs. 41.2% for portal vein proteins.

4/
How conserved is liver zonation between species? Re-analyzing our mouse scDVP data with the same framework showed: core metabolic functions are conserved, but ribosomal proteins show periportal enrichment only in humans - reflecting higher protein synthesis demands in oxygen-rich regions?

3c/
~47% of the proteome is zonated. 171 proteins show particularly strong spatial gradients. Explore any protein yourself: human-liver-dvp.streamlit.app

3b/
(2) A continuous gradient analysis assigning each protein a quantitative zonation coefficient - no binning required.

3 a/
Two key developments made this possible: (1) CellPick (cellpick.app) — a strategic cell selection framework maximizing spatial coverage per section, now a general tool for spatial (prote)omics.

2/
Liver divides labor spatially. Hepatocytes near portal veins perform different metabolic functions than those near central veins, known as liver zonation. Disrupted zonation are hallmarks of liver disease. A comprehensive protein-level map of human liver zonation was lacking. We provide one.

1/
18 individuals - 800 cells - 2,500+ proteins per cell. First author @carolineweiss.bsky.socialexplains further below.

Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture - Nature Metabolism Using the single-cell Deep Visual Proteomics technique, the authors develop a resource providing spatially resolved proteomic analysis of individual cells in human liver tissue.

Ever wondered how the human liver looks like at single-cell, spatial protein resolution? We used single-cell Deep Visual Proteomics to map human liver zonation at the protein level - one hepatocyte at a time. Our paper is out in @natmetabolism.nature.com! www.nature.com/articles/s42...

He was a visionary who helped make Denmark a powerhouse in proteomics and built a legacy through the many scientists he trained. Rest in peace, Peter.

Obituary for Peter Roepstorff Professor Peter Roepstorff passed away on 3 February 2026 at the age of 83. Thus ended a long research career focused on mapping the functions of proteins in living organisms.

Peter Roepstorff, one of the founding figures of biological mass spectrometry, has passed away at 83. As my postdoc advisor at the University of Southern Denmark, he showed me early on what MS could do for understanding proteins. sdunet.dk/en/enheder/i...

We compared 3 MS and 1 aptamer proteomics workflows on elite athlete plasma. Platform differences aren't just technical—they reveal distinct biology of exercise adaptation and metabolic health. New preprint just in time for Winter Olympics 🏆 🥇
biorxiv.org/content/10.6...

Discovery proteomics → clinical diagnostics? ADAPT-MS makes it possible by adapting to each sample's protein coverage on-the-fly. No imputation, no fixed panels, multiple diagnostic questions from one measurement. Out now in @natcomms.nature.com
www.nature.com/articles/s41...

Congratulations Dr. Vu!

In remembrance of Peer Bork  | EMBL EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.

Very sad to hear about Peer Bork's untimely passing. I have known him since my time at EMBL in the 1990s - a brilliant mind and wonderful collaborator. His contributions to bioinformatics were transformative. The community has lost a giant.
www.embl.org/news/embl-an...