Photo of Dr Luke Yates

'Huge' congratulations to Dr Luke Yates, on being awarded a highly competitive Academy of Medical Sciences' Springboard programme — for research investigating how cells coordinate the process of DNA repair, using advanced molecular imaging and genetic tools @acmedsci.bsky.social

Nature Communications banner with title of latest paper from the Yates, Oliver, and Rass groups at the Genome Damage and Stability Centre, University of Sussex: "Break-induced replication is enhanced by a phospho-activated RPA-binding module in Pol32".

An in-press version of our latest paper in @natcomms.nature.com on phospho-activated protein-protein interactions with ssDNA-binding protein RPA during BIR. If your favorite pathway involves RPA, this may be for you! Thanks to the lab, collaborators & @ukri.org!
www.nature.com/articles/s41...

Now live on Find-A-PhD-dot-com:
Joint project between @labneale.bsky.social and @drjonbaxter.bsky.social @gdsc-sussex.bsky.social
Get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.

www.findaphd.com/phds/project...

To kickstart this new Bluesky account: We're hiring!
The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab.
Details in the flyer — get in touch! 👇

Fantastic to see this published! Congratulations to all the authors on a very nice study.

DNA2 enables growth by restricting recombination-restarted replication - Nature DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex Nature Communications - Centromeres play an essential function in faithful chromosome segregation. Here, the authors demonstrate the mechanism by which human cells dynamically modulate the activity...

#NEW_PAPER

In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).

rdcu.be/eCGxF

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells Nature Communications - The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify...

#NEW_PAPER
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf

DNA2 enables growth by restricting recombination-restarted replication - Nature DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.

doi.org/10.1038/s415...

Exclusive Interview with Nobel Prize Winner John Jumper: AI's Next Frontier After AlphaFold YouTube video by Agents of Tech

Absolute pleasure to be invited back on the @agentsoftech.bsky.social podcast to join Stephen Horn and Laila Rizvi and talk with #Nobel winner John Jumper about #AlphaFold and research at Google DeepMind. We also touch on needing experimentalists, and what he & AI will tackle next in biology

I use Modevectors in PyMol pymolwiki.org/index.php/Mo... to depict the motion between my structures in this paper www.nature.com/articles/s41...

Congratulations!

Published online now in @annualreviews.bsky.social Annual Review of Biochemistry, Prof Zhang @crick.ac.uk and Prof Burgers @washu.bsky.social and I summarise current mechanistic understanding of DNA damage checkpoints, which act as a barrier to cancer in humans. www.annualreviews.org/content/jour...

I had a case where the grids were OUTSIDE of the grid box and were at the bottom of the dewar 😱 eBIC skilfully retrieved them and loaded - they were completely fine 😵‍💫

Dear all,

Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk

I have a funded PhD position in my lab in @gdsc-sussex.bsky.social (UK fees only).

This is an exciting new project using structural biology to investigate proteins involved in ovarian cancer, with opportunities for drug discovery and collaborations with clinicians. Application link below.

OK, I’ll bite - the Mre11/Rad50/Nbs1 complex?

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute.

Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!

3 postdoc positions advertised soon.

The Genome Damage and Stability Centre at the University of Sussex has now joined BlueSky! Follow us here, for news, views and publications.

Online today @science.org 👀Molecular basis of FIGNL1 in dissociating RAD51 from #DNA and #chromatin by @alexcarver.bsky.social @layates.bsky.social et al. in @imperialcollegeldn.bsky.social @mskcancercenter.bsky.social
www.science.org/doi/10.1126/...

Lovely structures, Alessandro!

Celebrating 70 Years of Organ Transplants: Inspiring Stories of Legacy, Innovation, and Hope YouTube video by WebsEdgeMedicine

The Equal Dose podcast by @websedgetv.bsky.social covered a topic very close to my heart - organ donation. And it was wonderful to share my story and very humbling to hear about Billy Moon’s legacy. Episode available here: youtu.be/9UAruhx2vk0?...

Building Blocks of Life, AlphaFold and AI Drug Development YouTube video by WebsEdge

It was a pleasure to be invited on the ‘Agents of Tech’ podcast from @websedgetv.bsky.social to talk about how AlphaFold3 is transforming structural biology and biomedical research. Link to the episode below: youtu.be/ohKGM6A9vhQ