Autologous and allogeneic stem cell-derived islet therapy in three recipients with type 1 diabetes and complete loss of endogenous pancreatic β-cell function pretransplant In a large population of people with type 1 diabetes, the glycaemic target might not be achieved despite insulin therapy and issues around recurrent severe hypoglycaemia caused by insulin excess can r...

(🧵18/18) Works from Feb+March 2026🍀.
From Dr. James Shapiro:
“Autologous and allogeneic stem cell-derived islet therapy in three recipients with type 1 diabetes and complete loss of endogenous pancreatic β-cell function pretransplant”
PMID: 41765034
www.thelancet.com/journals/lan...

(🧵17/18) Works from Feb+March 2026🍀.
From Dr. Michael Riddell:
“Beyond Euglycemia: Case Studies Using Continuous Glucose Monitoring in Elite Athletes Without Diabetes During Record Athletic Events”
PMID: 41829603
www.mdpi.com/1424-8220/26...

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(🧵16/18) Works from Feb+March 2026🍀.
From Dr. Michael Riddell:
“Advances in Exercise and Nutrition as Therapy in Diabetes”
PMID: 41800627
journals.sagepub.com/doi/10.1177/...

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(🧵15/18) Works from Feb+March 2026🍀.
From Dr. Michael Riddell:
“Continuous Glucose Monitoring–Derived Glucose Metrics Over Time in Physically Active Adults Without Diabetes Using a Commercial Continuous Glucose Monitoring Application”
PMID: 41773465
journals.sagepub.com/doi/10.1177/...

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(🧵14/18) Works from Feb+March 2026🍀.
From Dr. Michael Riddell:
“Marked Increases in Continuous Glucose Monitor-Detected Hypoglycemia During a Seven-Day Water-Only Fast in Healthy Men and Women”
PMID: 41724658
journals.sagepub.com/doi/10.1177/...

Realizing a vision to improve access to diabetes care Amidst the worldwide physician shortage, we share how realizing our vision can improve access to diabetes care. Central to this vision is a methodical…

(🧵13/18) Works from Feb+March 2026🍀.
From Dr. Rémi Rabasa-Lhoret:
“Realizing a vision to improve access to diabetes care”
PMID: 41794171
www.sciencedirect.com/science/arti...

(🧵12/18) Works from Feb+March 2026🍀.
From Dr. Marc Prentki:
“Non-enzymatic ABHD6 interacts with Akt-FoxO1 axis to regulate selective hepatic insulin resistance”
PMID: 41727161
www.biorxiv.org/content/10.6...

Integrated metabolomics and metagenomics analysis identifies a unique signature characterizing metabolic syndrome :Metabolic Syndrome (MetS) presents a global health challenge, characterized by obesity, hypertension, dyslipidemia, and insulin resistance. Despite r…

(🧵11/18) Works from Feb+March 2026🍀.
From Dr. Kacey Prentice:
“Integrated metabolomics and metagenomics analysis identifies a unique signature characterizing metabolic syndrome”
PMID: 41794383
www.sciencedirect.com/science/arti...

(🧵10/18) Works from Feb+March 2026🍀.
From Dr. M. Cristina Nostro:
“Efficient control of enterochromaffin versus islet differentiation from human pluripotent stem cell-derived pancreatic progenitors”
PMID 41851084
www.nature.com/articles/s41...

ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice with DPP-4 inhibition Obesity management has limited oral pharmacotherapies. Bitter taste receptor (TAS2R) agonists may modulate hunger, satiety, and metabolism via gut-bra…

(🧵9/18) Works from Feb+March 2026🍀.
From Dr. Timothy Kieffer:
“ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice with DPP-4 inhibition”
PMID: 41833222
www.sciencedirect.com/science/arti...

Frontiers | New-onset diabetes as an emerging risk group for early detection of pancreatic cancer: current evidence, clinical challenge, and future directions Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by late-stage manifestation and relative resistance to standard therapies. Challeng...

(🧵8/18) Works from Feb+March 2026🍀.
From Dr. James Johnson:
“New-onset diabetes as an emerging risk group for early detection of pancreatic cancer: current evidence, clinical challenge, and future directions”
PMID 41822268
www.frontiersin.org/journals/gas...

Insulin receptor trafficking and interactions in muscle cells AbstractContext. Insulin action is critical for energy homeostasis and its dysfunction in muscle cells is associated with type 2 diabetes. Insulin receptor

(🧵7/18) Works from Feb+March 2026🍀.
From Dr. James Johnson:
“Insulin receptor trafficking and interactions in muscle cells”
PMID: 41798897
academic.oup.com/jes/article/...

(🧵6/18) Works from Feb+March 2026🍀.
From Dr. Rebecca Hull-Meichle:
“Vascular Destabilization and Pericyte Detachment are Mediated by hIAPP Aggregation in Transgenic Mice”
PMID: 41756871
www.biorxiv.org/content/10.6...

Adiponectin deficiency and high fat and sucrose diets impair pancreatic islet adaptations to pregnancy and contribute to gestational hyperglycemia Gestational diabetes mellitus is characterized by hyperglycemia and impaired glucose tolerance with first onset in pregnancy. Clinical research shows an association between low circulating adiponectin...

(🧵5/18) Works from Feb+March 2026🍀.
From Christine Doucette:
“Adiponectin deficiency and high fat and sucrose diets impair pancreatic islet adaptations to pregnancy and contribute to gestational hyperglycemia“
PMID: 41793898
jpet.aspetjournals.org/article/S002...

Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases - Nature Reviews Endocrinology This Review outlines the potential role of hyperinsulinaemia as an independent driver of obesity and obesity-related conditions. Evidence regarding the potential causes of hyperinsulinaemia are summar...

(🧵4/18) Works from Feb+March 2026🍀.
From Drs. Jenny Bruin and James Johnson:
“Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases”
PMID: 41803509
www.nature.com/articles/s41...

Staying Functional Through Connection and Adaptation: When Islets Inspire Islet Biologists In response to the lockdowns and travel bans during the coronavirus disease 2019 pandemic, Peter C. Butler at the University of California, Los Angeles (UC

(🧵3/18) Works from Feb+March 2026🍀.
From Dr. Vincent Poitout
“Staying Functional Through Connection and Adaptation: When Islets Inspire Islet Biologists”
PMID: 41700931
diabetesjournals.org/diabetes/art...

Beta-cell adaptation to metabolic stresses requires prolactin receptor signaling | American Journal of Physiology-Endocrinology and Metabolism | American Physiological Society β-cell adaptation to maternal insulin resistance of pregnancy involves up-regulation of β-cell mass and function, a process we previously showed depends on prolactin receptor (PRLR) signaling. Emering...

(🧵2/18) Works from Feb+March 2026🍀.
From Drs Carol Huang and Erin Mulvihill:
“Beta-cell adaptation to metabolic stresses requires prolactin receptor signaling”
PMID: 41705537
journals.physiology.org/doi/abs/10.1...

(🧵1/18) Lots of new papers from the members of CIRTN🍀! Here are works from the labs of Drs Mulvihill, Huang, Poitout, Bruin, Johnson, Doucette, Hull-Meichle, Kieffer, Nostro, Prentice, Prentki, Rabasa-Lhoret, Riddell and Shapiro.

STARD10 regulates human pancreatic β cell differentiation and triglyceride metabolism Teo and colleagues uncovered the role of T2D-associated STARD10 lipid transfer protein in human beta cells. They found STARD10 to be important for proliferation and INS+ beta cell formation. Loss of S...

(🧵7/7) From the first half of February 2026.
From Dr: Guy Rutter:
“STARD10 regulates human pancreatic β cell differentiation and triglyceride metabolism”
PMID: 41687621
www.cell.com/stem-cell-re...

(🧵6/7) From the first half of February 2026.
From Dr: Guy Rutter:
“MTFP1 preserves β-cell cristae structure and bioenergetics to ensure insulin release and glucose homeostasis”
PMID: 41648185
www.biorxiv.org/content/10.6...

In vivo functional profiling and structural characterization of the human GLP1R A316T variant The GLP1R A316T missense variant displays improved glucose tolerance but impaired pharmacological incretin responses in vivo.

(🧵5/7) From the first half of February 2026.
From Dr: Guy Rutter:
“In vivo functional profiling and structural characterization of the human GLP1R A316T variant”
PMID: 41637494
www.science.org/doi/10.1126/...

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

(🧵4/7) From the first half of February 2026.
From Dr: Michael Riddell:
“Potential Applications of Inhaled Insulin in Diabetic Ketoacidosis Prevention and During Exercise: Two Case Presentations”
PMID: 41622414
journals.sagepub.com/doi/10.1177/...

Case Reports: Practical Use of Pulmonary Inhaled (Technosphere) Insulin in Type 1 Diabetes, Type 2 Diabetes, and Pregnancy - Irl B. Hirsch, Thomas C. Blevins, Amy M. Valent, Michael C. Riddell, 2026 Limitations in current insulin formulations contribute to suboptimal glycemic control and increased risks of hypoglycemia and hyperglycemia. Afrezza® with Techn...

(🧵3/7) From the first half of February 2026.
From Dr: Michael Riddell:
“Case Reports: Practical Use of Pulmonary Inhaled (Technosphere) Insulin in Type 1 Diabetes, Type 2 Diabetes, and Pregnancy”
PMID: 41622409
journals.sagepub.com/doi/10.1177/...

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro‐Oxidative and Pro‐Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction Adiponectin deficiency remodels the lipid composition of plasma extracellular vesicles (EV), enriching polyunsaturated phospholipids and reducing lysophospholipids. These remodelled EV impact oxidati...

(🧵2/7) From the first half of February 2026.
From Dr. Kacey Prentice:
“Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients...”
PMID: 41656969
isevjournals.onlinelibrary.wiley.com/doi/10.1002/...

(🧵1/7) Several publications coming out of CIRTN labs in the first half of February 2026🎉! This includes labs of Drs: Prentice, Riddell and Rutter.

Islet amyloid disrupts MHC class II antigen presentation and delays autoimmune diabetes in NOD mice - Diabetologia Aims/hypothesis Islet amyloid contributes to beta cell failure in type 2 diabetes through several mechanisms, one being the potent induction of local islet inflammation through activating inflammatory...

(🧵23/23) Jan 2026:
From Dr. Bruce Verchere:
"Islet amyloid disrupts MHC class II antigen presentation and delays autoimmune diabetes in NOD mice"
PMID: 41423547
link.springer.com/article/10.1...

B cells drive CD4 T cell immunosenescence and age-associated health decline B cells promote CD4 T cell aging and decline in health-span parameters through intercellular communication and nutrient sensing.

(🧵22/23) Jan 2026:
From Drs. Sue Tsai and Minna Woo:
"B cells drive CD4 T cell immunosenescence and age-associated health decline"
PMID: 41616067
www.science.org/doi/10.1126/...

Reduced fibre-fermenting capacity of gut microbes in multiple sclerosis may result in prebiotic dietary fibre β-fructan promoting inflammation and CNS damage Background Some people with multiple sclerosis display changes in their gut microbiota with separate evidence suggesting that symptoms may worsen following a high-fibre diet. We hypothesised that in p...

(🧵21/23) Jan 2026:
From Dr. Sue Tsai:
"Reduced fibre-fermenting capacity of gut microbes in multiple sclerosis may result in prebiotic dietary fibre β-fructan promoting inflammation and CNS damage"
PMID: 41585377
egastroenterology.bmj.com/content/4/1/...

ER calcium stores contribute to glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets Defective insulin secretion is a hallmark of diabetes mellitus. Glucose-induced Ca2+ oscillations are critical for the stimulation of insulin secretio…

(🧵20/23) Jan 2026:
From Dr. Guy Rutter:
"ER calcium stores contribute to glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets"
PMID: 41418583
www.sciencedirect.com/science/arti...

Frontiers | Effects of protein intake on glucagon, insulin, and glucose dynamics: implications for diabetes Carbohydrates are the main macronutrient of interest for dosing insulin and managing glycemia in type 1 diabetes (T1D) due to their direct impact on blood gl...

(🧵19/23) Jan 2026:
From Dr. Michael C Riddell:
"Effects of protein intake on glucagon, insulin, and glucose dynamics: implications for diabetes"
PMID: 41602572
www.frontiersin.org/journals/cli...