A targeted protein degrader that doubles as a cancer vaccine One molecule combines two approaches to waken dormant immunity against tumors

Meanwhile, in the lab: intratumor vaccination (or, if you will, "chemical reprogramming") guided by a PD-L1 degrader, all wrapped into one molecule

cen.acs.org/pharmaceutic...

I am organizing a Special Issue in Cancers with Eric Chastre & Larissa Kotelevets on PTEN Regulation. 7 papers published so far and deadline is fixed for 31 Dec 2025. Please reach out if you are interested in contributing.

Delighted to share our new preprint revealing a novel mechanism of ATR inhibitor sensitivity linked to lethal origin firing, thanks Sarah @mcclellandlab.bsky.social and collaborators!

VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation
www.cell.com/cell-chemica...

3 points of progress vs pancreatic cancer!
1. Neoantigen vaccines
www.nature.com/articles/s41...
2. KRAS drugs
www.wsj.com/health/healt...
3. Early diagnosis www.science.org/doi/10.1126/...

Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay A high-throughput, noninvasive, rapid protease-activated nanosensor identifies patients with pancreatic cancer in a small volume of blood.

A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at high-risk (PAC-MANN)
www.science.org/doi/10.1126/...

Congrats @lmkdassama.bsky.social and all co-authors for this comprehensive review on biodegraders! A must read.

Frontiers | Unravelling the druggability and immunological roles of the SOCS-family proteins

Happy to share our latest review on SOCS proteins and their role and therapeutic potential as targets in immunology. To date, drug discovery targeting SOCS proteins have been elusive, due to the difficulty to drug their polar SH2 domain.. 1/3

www.frontiersin.org/journals/imm...

It was a great pleasure to present @CellSymposia #CSchembio2024 our work on intracellular biodegraders in beautiful San Francisco!! Thanks to the organisers for this opportunity! @mariesorbara.bsky.social