Collectively, mapping the landscape of autosomal mCAs in populations of diverse ancestry illustrates similarities but also highlights important ancestry, geographic, and sex differences.

We also showed how mCAs impact blood transcriptomes, implicating stabilizing selection as a mechanism by which copy number gain mutations are tolerated in healthy blood.

We identified autosomal mCA hotspots that were ancestry- and sex-specific, mapped novel ancestry-specific germline variants associated with autosomal mCA prevalence, and estimated heritability rates to quantify the germline genetic contribution to autosomal mCA variance.

We profiled mCA, large chromosomal mosaic alterations in the blood of >60,000 participants European-descent and African cohorts, including a founding population cohort in Quebec, and individuals from within South, Central, West and East Africa.

Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood Clonal hematopoiesis, through the age-associated accumulation of somatic mutations in blood, is strongly associated with hematological malignancies and other chronic diseases. These mutations have lar...

New preprint live! www.medrxiv.org/content/10.1...
Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood

My first time awarding a PhD to a candidate, what a precious honour. Keep up the good work, students!

Now: @jsdron.bsky.social (JD): Age- and BMI-dependent genetic architecture of blood lipids in 2.5 million individuals from globally diverse populations #ASHG25 🧪🧬🖥️

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

Canada Research Chair Tier II in Applied Synthetic Biology | Faculty of Arts and Science - Concordia University The Department of Biology in the Faculty of Arts and Science at Concordia University invites applications for a tenure track faculty position and Tier II Canada Research Chair (CRC) in Applied Synthet...

Come join us in beautiful vibrant Montréal! Job opening for a CRC position in Applied Synthetic Biology at Concordia University. www.concordia.ca/jobs/artsci/... #ASHG25 #ASHG2025

I will be missing #ASHG25 but please keep posting about it! I can't wait to read all the updates of great science and people! #FOMO

Cell-extrinsic controls over neocortical neuron fate and diversity Cell-extrinsic cues are key for neocortical cell identity and diversity.

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Arctic glaciers face ‘terminal’ decline as microbes accelerate ice melt Scientists in Svalbard in race to study polar microbes as global heating threatens fragile glacial ecosystems

Interesting, well-written article from the Guardian.
www.theguardian.com/world/2025/a...

Music to my ears. This is brilliant. Either 90% of us can claim to be better musicians than Beethoven or… maybe just maybe polygenic scores aren’t perfect?

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early events during cancer development.

Nature research paper: Multigenerational cell tracking of DNA replication and heritable DNA damage

https://go.nature.com/4jxWDMJ

This ancient pathogen became deadlier when humans started wearing wool Ancient genomes reveal that a bacterial fever jumped from human-borne ticks to lice around the time wool textiles became common.

I never thought about wool as a possible route of infection.

www.nature.com/articles/d41...

On parle souvent de l'importance de la fluidité automobile au centre-ville. Pourtant, seuls 21% des déplacements vers le centre-ville se font en voiture. On devrait plutôt parler de comment améliorer le transport collectif (55%) et actif (23%) si on veut attirer les clients et travailleurs au c-v.

Assistant Professor (Research), Department of Microbiology & Immunology, (C2-240724) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Come join us at @mcgill.ca as an assistant professor in virus-host interactions! Please share widely.

mcgill.wd3.myworkdayjobs.com/en-US/McGill...

I’ll take it as a compliment today ☺️ maybe this retinol cream is working 😅

Getting mistaken for a student at my final exam ✅

Should I have pretended and write my own exam? 😁

This morning, teaching an undergraduate class in population genetics gave me hope and confidence for the future, those students are rocking it!!

Thanks your post made me realize how much I needed to hear that today ☺️

To the women in science. To the allies in science. To the ones who lift each other up.

I spend my life in science, constantly trying to figure out where I fit in. At times, it feels like pushing against an invisible force-one that questions, doubts, resists. But through it all, I am never alone. 🧵

Cephalopod sex determination and its ancient evolutionary origin Coffing et al. assemble a chromosome-level octopus genome assembly, revealing that the female octopus has just one sex chromosome (ZO karyotype), and males have two (ZZ karyotype). They conduct genomi...

Sex determination in cephalopods: hemizygosity (ZO) in females and ZZ males, and predates the radiation of the group 480 milions years ago. Fascinating work by Andrew Kern lab!

Our blood tests are interpreted by average reference values. That's missing a lot of rich information!
Each person has their own tightly regulated setpoints. One healthy person's complete blood count setpoint can be differentiated from 98% of other healthy adults.
www.nature.com/articles/s41...

When even your office phone knows you only as per your initials. #LongNameProblems

Hybridization lead to a reduced rate of LOH and influence
adaptation - Very cool work by the Landry lab!

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

Does my mutation have the same impact as yours? Population genetics 🤠 🥸 🤓 🤡 meets single cell CRISPRi ⚡ ! www.biorxiv.org/content/10.1... Led by Claudia Feng, Oliver Stegle, Britta Velten, @sangerinstitute.bsky.social .

Different statistical software/programming languages represented as different types of cars: Excel: Shown as a broken-down car with a person holding their head in frustration SPSS: Represented by a vintage brown station wagon from the 1980s SAS: Depicted as a classic black 1930s luxury car Python: Shown as a sleek, modern blue sports car with glowing effects MPLUS: Represented by a DeLorean with its distinctive gull-wing doors STATA: Shown as a modern blue SUV MINITAB: Depicted as a vintage red Vauxhall Chevette or similar compact car R: Represented by a scene from Mad Max: Fury Road with multiple modified post-apocalyptic vehicles

#RStats

that DeLorean though!

Would love to be included 😊