From the ɑβ- and γδ-TCR to important checkpoint inhibition targets like PD-1 and CTLA-4, this review gives focus to the important previous contributions from @imm.ox.ac.uk and collaborators to this field.

@ox.ac.uk @rdmoxford.bsky.social @imm.ox.ac.uk
(with @sumanasharma.bsky.social)

The Structural Biology of T‐Cell Antigen Detection at Close Contacts T cells physically interrogate their targets using tiny membrane protrusions called microvilli, forming junctions ~400 nm in diameter and ~ 15 nm deep, referred to as “close contacts”. These contacts...

Happy to share that our review on the structural biology of T-cell surface proteins is out in Immunological Reviews.

Here we describe the ways in which crystal structures and cryo-EM have informed our understanding of receptor behaviour and T-cell biology.

onlinelibrary.wiley.com/doi/full/10....

Wellcome Career Development Award For Sumana Sharma Dr Sumana Sharma has won a Wellcome Career Development Award for her research investigating receptors in T cells.

Congratulations to Dr Sumana Sharma (@sumanasharma.bsky.social), who has won a Wellcome Career Development Award for her research investigating receptors in T cells 🎉

Read more: www.imm.ox.ac.uk/news/wellcom...

@rdmoxford.bsky.social | @wellcometrust.bsky.social