Towards predictive virtual embryos with genomics and AI - Nature Methods Predictive virtual embryo systems that integrate single-cell and spatial data with artificial intelligence (AI) techniques offer a promising avenue for modeling mammalian embryogenesis across scales a...

Predictive virtual embryo models integrate single-cell and spatial data with AI, offering a tool for modeling mammalian embryogenesis across scales, as discussed in this Comment.

www.nature.com/articles/s41...

Submit your Breaking Abstract to #ESHG2026!

🗓 Be part of the “Late Breaking Abstracts” session on June 15 (10:30–12:00 CEST)

🚨 Deadline: April 28, 23:59 CEST (no extension!)

🔗 2026.eshg.org/abstracts/br...

The turning point for rare diseases, which affect >300 million people around the world.
A call to get rid of its many structural obstacles, to consider it as molecular surgery unlike drug treatments
gift link:
www.nytimes.com/2026/04/09/o...

Latest from Shendure & Qiu labs (@cxqiu.bsky.social)
)! We combined a new 4M cell mouse whole embryo scATAC-seq atlas (E10-P0), millions of 'evolutionarily coherent' orthologs from 241 mammalian genomes (Zoonomia), and the CREsted CNN framework (@steinaerts.bsky.social).

Super excited that our two companion papers on saturation genome editing (SGE) of RNU4-2 and discovery of a novel recessive neurodevelopmental disorder (NDD) were published yesterday 🥳

SGE experiment: www.nature.com/articles/s41...
Recessive NDD characterisation: www.nature.com/articles/s41...

🧵

"I find artists' creativity inspiring, and I hope to apply some of it to science"

Raquel Fueyo's lab studies the impact of transposons on human embryonic development and disease. We talked with her about what drew her to this field, her lab's work culture, and how she finds inspiration for her science in art. @fueyoraquel.bsky.social
Read more: www.molgen.mpg.de/news-2026-in...

Nuclear speckles of GC richness - Nature Reviews Molecular Cell Biology Nuclear speckles support the splicing of levelled exon–intron architecture transcripts, and their evolution shaped genome organization in amniotes.

The research highlight of our recent work on nuclear speckles is online. The photo choice is eggcellent. Happy Easter! 🌸🐰🥚
www.nature.com/articles/s41...

Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in dominant and recessive developmental and epileptic encephalopathies - Nature Genetics Analyses of snRNA genes in a French cohort of people with rare disorders, with validation through international collaboration, identify monoallelic and biallelic variants in RNU2-2 as frequent causes…

🧬Three papers newly published in Nature Genetics spotlight RNU2-2 as a major cause of recessive developmental and epileptic encephalopathies.
Congratulations to all three teams!

👉 www.nature.com/articles/s41...
👉 www.nature.com/articles/s41...
👉 www.nature.com/articles/s41...

Limitations of serial cloning in mammals - Nature Communications Here they show that extended serial somatic cell cloning imposes a threefold increase in de novo mutations compared to natural reproduction, progressively reducing birth rates and ultimately limiting clonal propagation to 58 generations.

Repeated cloning cannot be sustained indefinitely in mammals, according to a 20-year study in mice published in Nature Communications. The results suggest that sexual reproduction is necessary to eliminate large-scale genetic mutations that can accumulate in mammalian clones. 🧬 🧪

🌍 Can’t make it to Gothenburg? Join ESHG 2026 online!

💻 Live-streamed sessions
📅 6 months on-demand access
🌐 Global genetics insights

👉 2026.eshg.org/registration/

Reduced virtual registration fees for participants from low- & middle-income countries.

#eshg2026 #Genetics #Genomes #HumanGenetics

Monocyte-derived IL-10 drives sex differences in pain duration Peripheral monocytes and IL-10 are associated with shorter pain duration in males in both mice and humans.

Sex differences in pain duration
Finding interleukin-10 from monocytes as an/the explanation (in the experimental model and people
www.science.org/doi/10.1126/...

Professorship awarded to Mina Gouti Mina Gouti has been awarded a professorship at Charité – Universitätsmedizin Berlin. The appointment will strengthen her pioneering organoid research at the Max Delbrück Center and deepen collaboratio...

Congratulations to Mina Gouti on her promotion to Professor

www.mdc-berlin.de/news/news/pr...

Big congrats to the entire Kaessmann lab for this spectacular achievement and beautiful insights. It was a great honour to contribute to this study and to host Ioannis in our lab, an absolutely brilliant scientist. Evolution of genomic enhancers controlling neuronal cell types is just too cool..

We are thrilled that our study on the evolution of gene regulation in mammalian cerebellum development – led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social – is now out in @ScienceMagazine! www.science.org/doi/10.1126/...

This is figure 1, which shows AlphaGenome model architecture, training regimes and comprehensive evaluation performance.

A paper in Nature presents AlphaGenome, a deep learning model that can predict the function of long DNA sequences, up to one million base pairs. The tool can predict how DNA sequence variations affect different biological processes. go.nature.com/4t5JQa7 🧬 🧪

Interpretation, extrapolation and perturbation of single cells Nature Reviews Genetics, Published online: 02 January 2026; doi:10.1038/s41576-025-00920-4Causal and mechanistic modelling strategies, which aim to infer cause–effect relationships, provide insights into cellular responses to perturbations. The authors review computational approaches that harness machine learning and single-cell data to advance our understanding of cellular heterogeneity and causal mechanisms in biological systems.

FYI: New online! Interpretation, extrapolation and perturbation of single cells

🧬 Only one month until the 2nd meeting on early embryogenesis & epigenetics. #Embryo2026

Barbara Treutlein (@ethz.ch) will speak about her work reconstructing human brain development with organoids and single-cell technologies!

More information: www.molgen.mpg.de/embryo2026

An expanded registry of candidate cis-regulatory elements - Nature The existing ENCODE registry of candidate human and mouse cis-regulatory elements is expanded with the addition of new ENCODE data, integrating new functional data as well as new cell and tissue types...

Our paper on the newest version of the Registry of candidate cis-Regulatory Elements (cCREs) is out 🧬

Huge thanks to the many collaborators, experimentalists, analysts and software developers who made this work possible — truly a team effort!

A "meme-torial" of the science is coming soon 👀

Now out: The new ENCODE registry of candidate cis-regulatory elements (🐭/👶)

Major consortium effort, led by @moorejille.bsky.social - stay tuned for her "meme-torial"

www.nature.com/articles/s41...

@berkeleylab.lbl.gov @biosci.lbl.gov

Huntington's disease successfully treated for first time One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

Meanwhile, in countries that still do scientific research and medicine.....

www.bbc.com/news/article...

Excited to share our final accepted version of the CiFi method out today: www.nature.com/articles/s41...

Mapping single-cell diploid chromatin fiber architectures using DAF-seq - Nature Biotechnology Single-molecule chromatin fiber sequencing exposes single-cell-level heterogeneity in the chromatin architecture of individual regulatory elements.

Mapping single-cell diploid chromatin fiber architectures using DAF-seq
www.nature.com/articles/s41...

If you are planning to attend the Mutational Scanning Symposium (and companion workshops!) we recommend that you register as soon as possible to secure your spot!
ℹ️ www.mss2026.org
Keynotes! @mehurles.bsky.social @maitreya.bsky.social
#VariantEffect26 #Symposium #Workshop #RegisterNow

"We thank the reviewers for their helpful suggestions"

IMPRS-BAC #gradschool: Our new groupleader @sedonamurphy.bsky.social has an open PhD project in her lab. Topic: Spatial feedback between epigenetic regulation and chromatin regulation. Apply by Jan 7, 2026!
👉 www.molgen.mpg.de/5091778/Murp...

Ten days left to apply to be a @crick.ac.uk Early Career Group Leader

Closing date 27th November

www.crick.ac.uk/careers-stud...

📢 Speaker showcase for our 2nd Meeting #Embryo2026 🧬Vincent Pasque @pasquelab.bsky.social from @kuleuvenuniversity.bsky.social will speak about his work on modelling early human embryogenesis with naïve pluripotent stem cells.
More information👇
www.molgen.mpg.de/embryo2026

We were very happy to welcome this amazing group of early-career researchers as part of the @Falling Walls Science Summit in Berlin! Special thanks to @annaamonaco.bsky.social (Mundlos Lab) and @matthewkraushar.bsky.social for hosting the group and providing an in-depth tour of their labs!

Thrilled to start my Group Leader adventure with these and other great scientists!

Three new research groups joining the MPIMG

We are excited to welcome @fueyoraquel.bsky.social, @sedonamurphy.bsky.social, and @jmstein.bsky.social as new group leaders at our institute!
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...