Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr
We are looking for a postdoctoral scientist to work on challenging and exciting neuroproteomics problems. Close collaboration with @coscialab.bsky.social Apply: jobs.helmholtz-hzi.de/job/Braunsch...
... looking forward to re-connect in person next year, slightly jealous of y'all who made it to Melbourne! :)
Our new experimental evolution study across 30+ locations using the plant Arabidopsis thaliana —— we direct "see" adaptation and extinction to different climates at the genetic as it happens!
Read it in Science
dx.doi.org/10.1126/scie...
@ucberkeleyofficial.bsky.social
@hhmi-science.bsky.social
The latest AI/ML tools for co-folding proteins around small molecule ligands can produce impressive results.
Until you start looking at them closely.
Photo taken from the rear of a full auditirium. The opening slide of MSS 2026 is displayed on the screen
The Mutational Scanning Symposium 2026 has just opened in Melbourne, Australia. We can't wait to see all the fantastic talks and posters!
#VariantEffect26
On the uses and misuses of airborne DNA detection 🌬️🌱🧬
www.elperiodico.com/es/ciencia/2... 🇪🇸
with David Duffy @ufresearch.bsky.social in @elperiodico.com
Our warmest congratulations to #ICREAResearcher José Luis Riechmann and team at @cragenomica.bsky.social!
They discovered tiny peptides that could be key for flower development, conserved across plant species. 🌿🧪
Very few things in academia are as rewarding as witnessing the progress and growth of your students, their research and discoveries over the years.
Such a nice weekend read by @robjohnnoble.bsky.social 🫶 (also: great title!)
What a piece of art on L1! Big congrats to you all
Today in
@science.org:
We are pleased to present our last work entitled:
"Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis"
by Zumalave et al.
www.science.org/doi/10.1126/...
Wonderful to have David Duffy with us last week! Lots of new biodiversity genomics and eDNA approaches in the making ... 🧬🐢🌦️ @crg.eu @prbb.org @ufresearch.bsky.social
Two survival curves. One ('late') goes all the way down, the other ('early') stays well above it all the way and bottoms out at like 30%
This is just nuts.
In a well-powered randomised trial, giving immunotherapy in the morning rather than afternoon/evening produced ludicrously big improvements in progression-free survival
www.nature.com/articles/s41...
via
www.science.org/content/blog...
🌱 Join us tomorrow for the seminar "Deep mutational scanning of plant hormone receptors" by Maximilian R. Stammnitz (@maxstammnitz.bsky.social) from the Center for Genomic Regulation (@crg.eu)
👀 Don't miss it!
👉 https://f.mtr.cool/pgnowtoakf
Isomorphic Labs Drug Design Engine (IsoDDE), a unified computational drug-design system
Announcement:
www.isomorphiclabs.com/articles/the...
Report:
storage.googleapis.com/isomorphicla...
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
The power of plant hormones! 🌱+🪱
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
Why fundamental research is fundamental to progress, seeding major breakthroughs
Editorial @nature.com this week
And 7 basic science discoveries that changed the world
nature.com/articles/d41...
nature.com/articles/d41...
Congrats @ferriol.bsky.social and co!!
O maior fotógrafo do Brasil e um dos maiores do mundo descansa hoje. Vá em paz, Sebastião Salgado.
🎲 Our paper on the genetics, energetics, and allostery in proteins with randomized cores and surfaces is out today @science.org!
🧬 By charting a protein’s sequence universe, we could rationalize which versions were kept through evolution – and why many stable ones were not.
... so please have a look at our preprint and get in touch if you’d like to learn more, explore and use the data, etc 🙂
AND: definitely also check out @taylor-mighell.bsky.social's fascinating story on GPCRs – with even more receptor dose-response curves!
www.biorxiv.org/content/10.1...
[7/7]
Deep mutational scanning is developing really fast. One of the new directions lies in the exploration of larger, more dynamic proteins. Another in the study of small-molecule interactions.
Chemically inducible receptors and other glueable dimerisation systems offer us one way forward …
[6/7]
These rich data allow us to fit thousands of dose-response curves.
With these we can systematically compare mutants’ key signalling parameters including basal phosphatase binding, hormone sensitivity and maximum response.
And there are lots of cool examples & correlations, surprises … 🔎🕵️💚
[5/7]
Now what does one get out of this??
A massive map of position-, amino acid-, and small-molecule concentration-dependent variant effects!
[4/7]
To better understand this ABA receptor’s genetic encoding, we mutated every position to all 20 amino acids.
A glueable protein complementation assay (GluePCA) then allowed us to measure the relative binding strength of each receptor variant vs. phosphatase – at 12 different dosages of ABA.
[3/7]
PYR/PYL receptors (grey) are key to plant water homeostasis and stress signalling. 💦🌱🌞
Abscisic acid ('ABA', green), is bound through a deep hydrophobic pocket. This triggers the allosteric closure of two loops which generate a new binding interface with response phosphatases (white).
[2/7]
1 plant hormone receptor ☘️
3,500 mutants, to single-site saturation 🧬
>45,000 binding and abundance measurements 📶
Very happy to present our latest work – where deep mutational scanning meets the world of small molecules.
www.biorxiv.org/content/10.1...
With @benlehner.bsky.social
[1/7]
