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Posts by Brett J. Manley 🤷🏼‍♂️

Caffeine is good for the preterm brain; might more caffeine be even better? One of the pivotal RCTs in neonatology was the CAP study (Schmidt B, et al. Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med. 2007;357(19):1893–902). We performed that study because there was no data on the long term impacts of caffeine, and there was a worry that blocking adenosine receptors in babies having multiple hypoxic episodes might be a bad idea. Adenosine is an inhibitory neurotransmitter that is produced during hypoxia, and decreases the brain metabolic rate to protect against hypoxic damage. So giving caffeine to babies having a lot of apnoeas could potentially have been a bad idea.

Caffeine is good for the preterm brain; might more caffeine be even better?

One of the pivotal RCTs in neonatology was the CAP study (Schmidt B, et al. Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med. 2007;357(19):1893–902). We performed that study because there was no…

6 months ago 3 2 0 0

Global Neonatal Journal Club
Sept 24th 1700 AEST

Discussing: Lancet Commission on the Future of Neonatology, incl. interviews w/ Danny DeLuca & Steve Abman

Featuring: Arti Maria, Alex Stevenson, Hoang Thi Tran, Patrick Too, Tendai Mutema & Peter Davis

mercyhealthau.zoom.us/webinar/regist…

7 months ago 1 0 0 0
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NEONATAL RESPIRATORY TRIALS IN SICK & PRETERM NEWBORN INFANTS With Professor Brett Manley, Consultant Neonatologist Mercy Hospital For Women, Melbourne & Professor of Neonatal Medicine Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Australia youtu.be/NAY_0xBGsrw

8 months ago 1 1 0 0

Read this!

8 months ago 3 0 0 0
Cool Topics in Neonatology 2025 | The Royal Women's Hospital

Delighted & honoured to be contributing to the iconic “Cool Topics in Neonatology 2025” at The Women’s Melbourne with great friends & colleagues!
@ebneo.bsky.social @drbretty.bsky.social @nnrdbase.bsky.social @europerinatal.bsky.social
www.thewomens.org.au/health-profe...

9 months ago 7 5 0 0
https://www.eventbrite.com.au/e/cool-topics-in-neonatology-2025-tickets-1393383139479?aff=oddtdtcreator

Registration for Cool Topics in Neonatology 😎 November 2025 in Melbourne is NOW OPEN! #neosky

Anup Katheria!
Neena Modi!
Richard Martin!
TORPIDO 30/60 results!
Coconut oil trial (COSI-2) results!
AIROplane results (maybe)!

t.co/DwpA3rkUCi

9 months ago 3 2 0 0
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Thrilled to have Prof. Georg Schmölzer @research4babies.bsky.social presenting on resuscitation studies @mercyperinatal.bsky.social #neosky

1 year ago 5 3 1 0
AAP SONPM Journal Club - March 19th, 2025 - PLUSS Trial
AAP SONPM Journal Club - March 19th, 2025 - PLUSS Trial YouTube video by Neo TECaN

The most recent AAP SONPM Journal Club webinar is available - youtu.be/beh82Mgor7Q
Dr. Aung (Neonatal-Perinatal Fellow, St. Christopher's Hospital) gave an excellent overview of the PLUSS trial. Thank you to @drbretty.bsky.social and Dr. Watterberg for joining! #neobluesky

1 year ago 4 3 1 0
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There’s a specific reason I have the idk 🤷🏼‍♂️ emoji in my profile

It’s because idk 🤷🏼‍♂️ a LOT of stuff, and openly admit that

We are playing catch up in neonatology because we have so many established practices that are not strongly based in evidence

#neosky

1 year ago 21 7 4 0
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Adapt to survive and thrive: the time is now for adaptive platform trials for preterm birth In this Viewpoint, we discuss the challenges facing perinatal clinical researchers, many of which are unique to this field, and how traditional two-arm randomised trials using frequentist analysis mig...

Have you read our article about adaptive platform trials for preterm birth yet? #neosky

We discuss the challenges facing perinatal clinical researchers and how traditional RCTs may no longer be fit for purpose in our field.

Are APTs the answer?

www.thelancet.com/journals/lan...

1 year ago 6 5 0 0
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When you suggest extubating instead of increasing sedation and it goes really well #neosky

1 year ago 5 0 0 0

Keith Barrington’s thoughts on @platipus.bsky.social #neosky

1 year ago 1 0 0 0
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Keeping the baby still in the MRI #neosky

1 year ago 5 0 0 0
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Save the dates for Cool Topics in Neonatology 😎

November 27-28, Melbourne 🇦🇺🦘

With:
⭐️ Anup Katheria 🇺🇸
⭐️ Neena Modi 🇬🇧
⭐️ Richard Martin 🇺🇸
… and many more!

Additional workshops and details to be announced in the coming months.

1 year ago 4 1 1 0

So excited to share our commentary out now in LancetCAH and freely available via the link below!

The time is NOW for Adaptive Platform Trials to improve outcomes for preterm infants! @platipus.bsky.social

url.au.m.mimecastprotect.com/s/ukzLCmOxr6...

1 year ago 3 2 1 1
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Attending #PAS2025?

Don't miss our workshop on Evaluating Trustworthiness: Identifying Spin, Fraud, and Deception in Modern Research

Date: Friday, April 25, 2025
Time: 4:00 PM - 5:30 PM

@ebneo.bsky.social
Rasheda Vereen @atulmalhotra.bsky.social @briankingneo.bsky.social @drabdulrazak.bsky.social

1 year ago 10 7 0 0

In ÉCLAT, extubating extremely preterm infants to a CPAP of 10 (range 9-11 for 24 hrs) vs. 7 (range 6-8 for 24 hours) decreased extubation failure, without obvious safety issues.

PEEPophobes lament! 😪

1 year ago 6 2 0 0
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In this cohort study, Lipp et al compare neonatal outcomes & neurodevelopmental outcomes between extremely preterm infants(23–25 wks GA) managed with noninvasive respiratory support & those intubated during 30 min after birth buff.ly/3WuTe8L
#neosky #neoEBM #EBNEOalerts

1 year ago 3 3 0 0
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In this multicenter RCT, Greenberg et al compare proportions of preterm infants who had apnea and other adverse events in the 48 hours after 2-month vaccinations vs after no vaccinations. buff.ly/423iztP @jama.com
#neosky #neoEBM #EBNEOalerts

1 year ago 5 2 0 0
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Congrats to the MATISSE & ECLAT trials - finalist in 2023 @ebneo.bsky.social Impact Article of the Year campaign! Consider both below & navigate to buff.ly/3R5JhMy on 12/31/24 to cast your final vote!

MATISSE: buff.ly/418aHni

ECLAT: buff.ly/4fzwECw

#neosky #neoEBM

1 year ago 3 1 0 0
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ÉCLAT of course! 🥇

1 year ago 2 1 0 0
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A very big day for our PhD student, and neonatal nurse, Anna Kidman today, as her PhD was conferred from The University of Melbourne.

Her PhD supervisors, @drbretty.bsky.social , Risha Bhatia, Prof Peter Davis and myself are very proud of her achievements, and congratulate her- Dr Anna Kidman.

1 year ago 9 1 0 0
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#neosky
#pediatrics

1 year ago 78 11 4 3
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APT.

One for all the Adaptive Platform Trial enthusiasts out there!

Go on… Meet me at the A.P.T. 🎶

@platipus.bsky.social #MedSky #NeoSky #NICUSky
open.spotify.com/track/5vNRhk...

1 year ago 2 0 0 0

I hope you demanded a premicath! 🤣 Seriously though, all the best and get well soon.

1 year ago 2 0 1 0

I’m pretty sure it lulls the pH into a false sense of security with light conversation, waits patiently for the base excess to leave the room, and…. Bam!

The lactate never even saw it coming.

1 year ago 1 0 0 0
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ABC3 trial shows that physiological-based cord clamping in very preterm infants did not increase survival without major cerebral injury or NEC compared to time-based cord clamping. @thelancet.bsky.social
buff.ly/3ZHyFrD
#neoEBM #EBNEOalerts #neosky

1 year ago 10 8 0 0
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A close look at the evidence-base for treating the most premature babies, as in international newborn early-life care guidelines (ILCOR, ERC and Euro-RDS consensus) - take a look and share your thoughts
@ebneo.bsky.social
doi.org/10.1016/j.jp...
@drbretty.bsky.social @donsharkey.bsky.social

1 year ago 14 8 1 0
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This week's #Neographic for #Neosky - A periviable infant (~ 22 to 23 weeks gestation). Immaturity of multiple organs plays an important role in outcomes - lung airspace and vascular immaturity leads to respiratory failure and high incidence of pulmonary hypertension; #NEOCON2024

1 year ago 21 7 1 1