🚀 We’re hiring! EMBL TechDev Internship (TDI25-14)

We’re looking for an organic chemist to help develop novel fluorogenic HaloTag ligands for deep-tissue imaging. You’ll contribute to molecular design and run in silico, in vitro, and microscopy-based assays to quantify fluorophore performance.

Thank you!

Thank you!

Thank you Carolyn!

New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇

www.biorxiv.org/content/10.1...

Thank you!

Bridging Light and Sound: a Spironaphtopyran-Rhodamine Dyad with High-Contrast Photoswitching Between Fluorescence and Photoacoustic Signal Fluorescence and photoacoustic imaging are complementary modalities that provide distinct advantages for biological imaging: fluorescence microscopy offers high sensitivity and resolution, while photo...

Happy to share our new preprint, a fantastic collaboration with @prevedel-lab.bsky.social ! We developped a probe that can switch between fluorescence and photoacoustic contrast upon illumination. Congrats to @kaydanych.bsky.social and Magda who led this project.
www.biorxiv.org/content/10.1...

Thanks Brian !!

A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells Photoswitchable fluorophores are critical for advanced bioimaging. Here, we develop a photoswitchable self-labeling HaloTag that can reversibly modulate the emission of a bound fluorogenic dye via a ....

Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....

Thanks Brian!!! Great to present at my favorite seminar series 😊!

Applications are now open for the 4th edition of the “Ecole de Physique des Houches” on Fluorescence Markers for Advanced Microscopies, a WE-Heraeus seminar.
March 15th-20th 2026
Join us to learn everything you wanted to know about Fluorescent Markers for advanced microscopies.

Research Technician - Open Chemistry Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147 Current HHMI Employees, click here to apply via your Workday account. Summary: Open Chemistry is a collaborative research group whose missio...

We're looking for 1-2 enthusiastic early career chemists to join our Open Chemistry team at @hhmijanelia.bsky.social. Come help us create amazing dyes and share them with the world. Please share with the best recent/soon-to-be B.S. chemists you know! bit.ly/42w8C6N

Advertisement for PhD position

My lab at @ethzurich.bsky.social is looking for a motivated PhD student. We develop chemical tools for advanced fluorescence microscopy 🔬 and work at the interface of synthetic chemistry ⚗️ and protein engineering 🦠. Sharing with skilled Master students appreciated. More info at tinyurl.com/2dbjk5ty

🧵Prepint alert! Optimizing Multifunctional Fluorescent Ligands for Intracellular Labeling | tinyurl.com/3n55hvsc. With Jason Vevea, Ed Chapman, and @so-lets-kilab70.bsky.social, we combined dye chemistry, HaloTag, microscopy and cell biology to make protein purification and manipulation tools.

Quantitative Imaging: From Acquisition to Analysis Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Join me, @talleylambert.bsky.social, @bethcimini.bsky.social, @florianjug.bsky.social & Hunter Elliott for our two week CSHL course on microscopy & image analysis starting March 24, 2025! Applications are due 1/31/25. meetings.cshl.edu/courses.aspx...

General principle of photoswitchable HaloTag (psHaloTag) and open-closed equilibrium of JF635-HaloTag ligand (HTL).

A photoswitchable HaloTag for spatiotemporal control of fluorescence in living cells by @clairedeo.bsky.social and team:
www.biorxiv.org/content/10.1...

We made a photoswitchable HaloTag (psHaloTag), which can reversibly turn-on fluorogenic dyes upon illumination 💡. Congrats to Franzi, Bego and all co-authors, check out our preprint below 👇
www.biorxiv.org/content/10.1...