Flexible ensheathment of axons enables myelination of complex CNS networks - Nature The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide&nbsp...

Latest offering. How myelin ensheathes axons!

Born from chat with Dwight Bergles on "weird things" we saw oligodendrocytes do, like making "bridges" between sheaths.

Driven forward by Cody Call, Kelly Monk, and myelin folks @edinburgh-uni.bsky.social

Enjoy!
www.nature.com/articles/s41...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

Thrilled that our paper is now published. It’s been a real privilege to work on this project together with co-first author @ara-donia.bsky.social, under the supervision of @lyons-lab.bsky.social, and with such an outstanding team in Edinburgh and internationally!
www.science.org/doi/10.1126/...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

I am delighted to see this work published. A big thanks to everyone, particularly the excellent supervision of @lyons-lab.bsky.social, the work of co-first author @juliavdkorput.bsky.social and wonderful collaborators in Amsterdam and Oregon.
www.science.org/doi/10.1126/...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social

Huge team effort, with immense contributions by friends from nearby and around the globe.

www.science.org/doi/10.1126/...

Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors Oligodendrocytes form myelin sheaths around axons to enable rapid signaling within neural circuits. The generation of new oligodendrocytes through differentiation of oligodendrocyte precursor cells (O...

alert! fundamental myelin biology - led by the amazing Yevgeniya Mironova and Dwight Bergles www.science.org/doi/10.1126/...

Prof Khakh quote - I hope to make a meaningful difference to the lives of people affected by dementia by advancing new therapeutic mechanisms grounded in fundamental neuroscience, and by helping to build a research environment where great science and great scientists can thrive.

Very excited to share the news today that Professor Baljit Khakh will become the new Centre Director of the UK DRI at Cardiff University!

Read our full announcement 👉 www.ukdri.ac.uk/news-and-eve...

Led by Marcus Keatinge
"Mislocalisation of TDP-43 to the cytoplasm of either neurons or oligodendrocytes causes axonopathy and dysmyelination"

www.biorxiv.org/content/10.1...

A man in a lab coat stands in a laboratory witht he background lab lit up in purple and blue

£70 million investment in IRR spinout Trogenix to tackle aggressive cancers.
The funding will enable the rapid advancement of its pipeline of potentially curative cancer therapies across multiple treatment-resistant cancers
regeneration-repair.ed.ac.uk/ps70-million...
@edinnovations.bsky.social

www.nature.com/articles/s41...

Brilliant Kick off day #ISNASN2025
@neurochemistry.org with the best conference views ever 😎
Glad to be part of it #TogetherForScience

If you wanna know more about my work on axons & zebrafish in the @lyons-lab.bsky.social join me during the poster session tmr evening (LBA45) or just reach out 🐠

Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...

For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker

www.nature.com/articles/s41...

The LSI Exeter invites you to join the first UK Zebrafish Meeting, 10/ - 12/9/ @lsiexeter.bsky.social. We are looking for motivated PhD students/ECRs to present their work - as talks and posters. www.exeter.ac.uk/research/ins... . The deadline for the early bird registration is 15/5/. So, be quick!

Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals Optical recording of intricate molecular dynamics is becoming an indispensable technique for biological studies, accelerated by the development of new…

Fun to have contributed a little to this, led by the team of the incomparable Guoqiang Yu.

Suspect that this will prove to be an immensely popular image analysis platform for interrogation of dynamic signallingl!
www.sciencedirect.com/science/arti...

Hot damn!
Spectacular news Karl. Massive congrats Michelle!@michellemonje.bsky.social

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates Hasel et al. show that molecularly and morphologically specialized astrocytes make up the brain and spinal cord surface, thereby creating the glia limitans superficialis. These astrocytes selectively ...

Our paper on the superficial glia limitans is now published - huge thank you to all co-authors that helped getting this work across the finish line! www.cell.com/cell-reports...

Two new opportunities in Edinburgh:

Research technician in our lab
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Senior research technician to support the Zebrafish Imaging and Screening Facility
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

One week to go before application deadlines...

1. Postdoc, investigating how neurons respond to demyelination.
2. Research assistant, investigating how conduction properties are established in neural circuits

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Couple of opportunities up to join the group!
One at postdoc level, but open to senior support path.
One research assistant role.
Please share, or drop a line if you want to learn more!
Or just apply!
Thanks!

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes Myelination facilitates the rapid conduction of action potentials along axons. In the central nervous system (CNS), myelinated axons vary over 100-fold in diameter, with conduction speed scaling linea...

First post at this side.

Latest axon diameter action led by Jenea Bin, in collaboration with Nolan, Mobius, Monk, Werner, and Emery labs.

www.biorxiv.org/content/10.1...