Thank you to @cp-devcell.bsky.social for selecting our story to feature on the cover of today’s issue of Developmental Cell!
Thank you to Zoë Ruiz for the wonderful art work! Read more here: www.cell.com/developmenta...

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

part of figure 5 from the linked preprint. shows 3d plot of fluorescent data where strong signal looks like dark mountains rising above a gray floor.

Cool work from Sarah Bray's lab at Cambridge looking at Notch-induced transcription hubs:
www.biorxiv.org/content/10.1...

from Fig 5: hubs are stabilized/strengthened when initiation is inhibited and diminished when P300 is inhibited.

A big mission of @crick.ac.uk is to bring Science to everyone. Thank you chris agathangelou and Clare green for your help with making our latest work on a new stem cell model of the human amnion accessible to all 🙏

Very proud to be among the authors of this story!

Big welcome to the lab to physicist turned quantitative biologist Beth Westbrook @bethwestbrook.bsky.social! Beth did her PhD in Jonathan Chubb’s lab at UCL and has been very interested in how fate transitions are coordinated. We are lucky she joined our lab for her postdoc!

So excited for this new chapter and honoured to have been invited to join such a talented team!

Transcription factor hubs exhibit gene-specific properties that tune expression The spatial and temporal control of gene expression relies on transcription factors binding to and occupying their target sites. Transcription factor hubs - localized, high-concentration microenvironm...

1/n: Excited to share our new preprint. We find that Dorsal transcription factor hubs exhibit gene-specific biophysical properties that tune transcriptional output. Read here: www.biorxiv.org/content/10.1.... Project was led by amazing graduate student Samantha Fallacaro (not on bsky)