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Posts by Hesper Rego

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We are recruiting postdocs to work on antimicrobial resistance and bacterial cell envelope biology. PLEASE SHARE.

1 week ago 16 27 1 0

We've been we've been working on this for quite a while now (hopefully published soon). Grateful to @proftracypalmer.bsky.social for concinving me & @lislowe.bsky.social that mycobacteria produce inter-bacterial toxins. Team science, led by @sambenedict5.bsky.social www.biorxiv.org/content/10.6...

3 weeks ago 48 26 4 6
Activation of l-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis - Nature Communications Here, the authors report metabolic activation as a potential antimicrobial strategy against Mycobacterium tuberculosis. They show that supra-physiological activation of L-histidine biosynthesis r...

All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy?

Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation.

www.nature.com/articles/s41...

(1 out of 3)

3 weeks ago 67 32 6 2

Abi cook did the impossible and measured homeopathic amounts of metabolites in single mycobacterial infected macrophages preserving spatial information.

1 month ago 3 3 0 0
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

We are searching for a tenure-track junior faculty member. Join our collaborative research environment in the Department of Microbiology and Immunology at WCM. Please see the link to the job posting and distribute among your networks!
apply.interfolio.com/181869

1 month ago 7 4 0 0
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Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...

๐ŸŽ‰ ๐„๐ฑ๐œ๐ข๐ญ๐ž๐ ๐ญ๐จ ๐ฌ๐ก๐š๐ซ๐ž ๐จ๐ฎ๐ซ ๐ง๐ž๐ฐ ๐ฉ๐ฎ๐›๐ฅ๐ข๐œ๐š๐ญ๐ข๐จ๐ง ๐ข๐ง ๐“๐ก๐ž ๐„๐Œ๐๐Ž ๐‰๐จ๐ฎ๐ซ๐ง๐š๐ฅ!

After 8 months of revision, our work is now online: shorturl.at/WHmFq

We uncover a previously unrecognized way that ๐‘€๐‘ฆ๐‘๐‘œ๐‘๐‘Ž๐‘๐‘ก๐‘’๐‘Ÿ๐‘–๐‘ข๐‘š ๐‘ก๐‘ข๐‘๐‘’๐‘Ÿ๐‘๐‘ข๐‘™๐‘œ๐‘ ๐‘–๐‘  survives toxic metal stress during infection.
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2 months ago 31 20 1 1

Monitoring intracellular antibiotic concentrations in real-time using allosteric biosensors www.biorxiv.org/content/10.64898/2026.02...

2 months ago 4 2 0 1
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Thank you! It was great working together and happy to see this out!

3 months ago 0 0 0 0