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It's very long, and quite dense in places, so here are my favourite hosts discussing it.

Beware, this is a half hour NotebookLM AI generated conversation. I've not had a chance to check it got all the details right...

notebooklm.google.com/notebook/9bf...

Disease-modifying pharmacological treatments of type 1 diabetes (T1D): Molecular mechanisms, target checkpoints and possible combinatorial treatments. After a century of extensive scientific investigations, there is still no curative or disease-modifying treatment available that can provide long-lasting remission for patients diagnosed with Type 1 D...

If you haven't heard of them, Levicure are creating a treatment that delays the onset of Type 1 using GABA, DPP-4 inhibitors and Omeprazole.

They just published their paper on "how type 1 diabetes works and what you can do to counter it" .

pharmrev.aspetjournals.org/article/S003...

It's also because it helps to down regulate glucagon production by the same pathways that in a healthy system, increase insulin response.

Add in GABA (another key missing endocrine component) and you really start to see the effects.