The rise of spatial TCR profiling: Emerging technologies and open challenges Spatial TCR profiling has the potential answers to key questions in cancer immunology, but challenges remain.

The rise of spatial TCR profiling: Emerging technologies and open challenges | Science Immunology www.science.org/doi/10.1126/...

Improving immunotherapy in solid tumors using FMT Recent clinical trials demonstrate that fecal microbiota transplantation (FMT) enhances first-line immune checkpoint inhibitor efficacy in renal cell carcinoma, cutaneous melanoma, and non-small cell ...

Improving immunotherapy in solid tumors using FMT: Cell www.cell.com/cell/fulltex...

Landmark ancient-genome study shows surprise acceleration of human evolution Data from more than 15,000 ancient people reveal natural selection of hundreds of genes linked to immunity, skin tone, behaviour and other traits.

Landmark ancient-genome study shows surprise acceleration of human evolution www.nature.com/articles/d41...

Massive budget cuts for US science proposed again by Trump administration The 2027 budget proposal would curb federal payments for scientific publishing and reduce funding for many US institutions.

Massive budget cuts for US science proposed again by Trump administration www.nature.com/articles/d41...

A clinic-responder-derived defined microbial consortium enhances anti-PD-1 immunotherapy efficacy in mice - Nature Microbiology A rationally designed 15-member bacterial community engrafts and promotes T cell responses and anti-PD-1 therapy across heterogeneous baseline microbiotas to promote cancer control in mice.

www.nature.com/articles/s41...
Role of specific microbiota in successful cancer immunotherapy 👇

Planetary microbiome structure and generalist-driven gene flow across disparate habitats A planetary-scale analysis of over 85,000 metagenomes establishes a framework for exploring the structure and drivers of global microbial habitats, revealing that generalist species bridge ecological ...

Planetary microbiome structure and generalist-driven gene flow across disparate habitats: Cell www.cell.com/cell/fulltex...

Anticancer antibodies can evolve to cause autoimmune brain disease Immune cells called B cells recognize the NMDA receptor expressed on some cancers and produce antibodies targeting it.

Anticancer antibodies can evolve to cause autoimmune brain disease www.nature.com/articles/d41...

Island birds reveal surprising link between immunity and gut bacteria - Quadram Institute Scientists have uncovered a hidden link between gut health and the immune system – thanks to the Seychelles warbler, a small songbird found on Cousin Island in the Seychelles

The findings from a new study show that immune genes shared by all vertebrates – including humans – interact closely with gut bacteria.

Memory loss is fuelled by gut microbes in ageing mice If confirmed in people, the finding might lead to gut-targeted therapies that could reverse cognitive decline.

Memory loss is fuelled by gut microbes in ageing mice www.nature.com/articles/d41...

Charting the circulating proteome in ME/CFS using cross-system profiling to uncover mechanistic insights Hoel et al. characterize circulating proteomic signatures in ME/CFS and identify widespread tissue-linked alterations, including increased secreted proteins and reduced intracellular proteins. Protein...

Charting the circulating proteome in ME/CFS using cross-system profiling to uncover mechanistic insights: Cell Reports Medicine www.cell.com/cell-reports...

New HIV cure approach forces hidden virus into tripping immune sensor Strategy gains momentum after promising results in cell studies and infected people

New HIV cure approach forces hidden virus into tripping immune sensor | Science | AAAS www.science.org/content/arti...

A single course of antibiotics can have lasting effects on your gut microbiome, with changes that last well beyond 4 years. Three types of antibiotics stood out for their long term disruptive impact (3 at left, Figure)
nature.com/articles/s41...

β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer β-hydroxybutyrate (BHB), the ketone body associated with a ketogenic diet, metabolically reprograms and fuels CAR T cells to achieve proliferation, cytokine production, and superior tumor control. The...

β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer: Cell www.cell.com/cell/fulltex...

I’ve been lucky to know many great scientists, but Robin was really way up there as a creative thinker, intellect, pioneer - yet, unusually, managed to combine this with being utterly kind, generous, warm. We’ll miss him

Conserved CD4+ T cell staphylococcal and streptococcal epitopes enable broad-acting vaccines in mice - Nature Microbiology Immunopeptidomics identify CD4⁺ T cell epitopes from the conserved bacterial Hup protein that confer protection against multiple bacterial infections in mice suggesting potential for development of br...

www.nature.com/articles/s41...

A pen and ink drawing of a dragon by Michelangelo

Michelangelo was born on this day in 1475 in Caprese near Florence, Italy. The painter, sculptor, architect and poet is widely considered to be one of the greatest artists of the Italian Renaissance period.

Immune cells from the gut drive development of Parkinson’s disease in the brain In ‘body-first’ Parkinson’s disease, misfolded proteins propagate from the gut’s nervous system to the brain. Immune-cell activity seems to play a key part in this spread.

Immune cells from the gut drive development of Parkinson’s disease in the brain www.nature.com/articles/d41...

Measles is raging worldwide: are you at risk? Cases in fully vaccinated people are rare and usually mild, but are likely to become more common as exposure to the virus rises.

Measles is raging worldwide: are you at risk? www.nature.com/articles/d41...

Thanks for getting in touch. We are indeed particularly interested at present in people able to get to us for a blood test. Also, please bring your ‘healthy control’ friends. Contact:
Altmannlongcovidstudy@imperial.ac.uk

Calling family and friends of the @meassociation.org.uk
Your fundraising pays for vital research and services for people with #ME/CFS. Help the charity make a difference in 2026.
From quizzes and head shaves to marathons, they can support you all the way.
Details: meassociation.org.uk/cgnm

COVID-19 vaccination status during pregnancy and preeclampsia risk: the pandemic-era cohort of the INTERCOVID consortium COVID-19 vaccination with a booster reduces the odds of PE by 30% approaching 60% reduction among women with pre-existing morbidities.

COVID-19 vaccination status during pregnancy and preeclampsia risk: the pandemic-era cohort of the INTERCOVID consortium - eClinicalMedicine www.thelancet.com/journals/ecl...

There is a measles outbreak in London, which has been widely reported.

Vaccination rates are low.

And we have been warned that an outbreak could be large.

Some of the reasons are due to misinformation and disinformation. Thankfully the Government appears to be waking up.

A thread.

What’s going on with Measles in England? An explanation of where we are, how we got here and what we can do

Excellent from @chrischirp.bsky.social on the current measles outbreak in London and what this says about vaccine uptake and what we can do to address it

Exclusive: Key US infectious-diseases centre to drop pandemic preparation Staff members have been instructed to scrub this topic and ‘biodefense’ from the agency’s website.

The pandemic preparedness programme at NIAD is to be cut in yet another inexplicable decision by Bhattacharya. Without the research that was done by institutes such as the NIAD that was already looking at coronaviruses we would not have had such speedy vaccine development 🧪🧵 #HealthPolicy

‘We almost lost you in the night’ - the life-threatening rise of measles in the UK It is one of the most infectious diseases around, and can cause blindness and hearing loss – and can also be fatal. Why are cases now soaring and what can be done about it?

Pneumonia, blindness, hearing loss and brain inflammation are just some of the impacts measles can do and these are heartbreaking accounts shared here. Measles is extremely infectious but also preventable by the full course of the MMR vaccine #MMR #Measles

In our lifetimes we’ve witnessed HIV, Ebola, SARS, MERS, Covid and others.
Hard to take that our learning point for the next ones is to close eyes and hope for the best…

Exclusive: Key US infectious-diseases centre to drop pandemic preparation Staff members have been instructed to scrub this topic and ‘biodefense’ from the agency’s website.

Not preparing for the next pandemic doesn't prevent pandemic from happening.
www.nature.com/articles/d41...

Daily briefing: Caffeine might reduce dementia risk and slow cognitive decline Daily cups of coffee and tea have been linked to slower brain ageing. Plus, a view of global hot and cold weather extremes and tips for commanding the conference stage.

Daily briefing: Caffeine might reduce dementia risk and slow cognitive decline www.nature.com/articles/d41...

FDA declines to review Moderna application for new flu vaccine Moderna requests meeting to discuss refusal as decision could have implications for all new and updated vaccines

Vinay Prasad has refused to review Moderna's application to license a new updated flu vaccine for the USA- why - this is puzzling because he basically made up a reason as he claims a trial was not done that was in fact performed. This has huge implications for licensing new vaccines in the States

National Cancer Institute studying ivermectin’s ‘ability to kill cancer cells,’ alarming career scientists The National Cancer Institute is studying ivermectin as a potential cancer treatment, according to its top official, alarming career scientists.

National Cancer Institute studying ivermectin’s ‘ability to kill cancer cells,’ alarming career scientists

The NCI director didn’t cite new evidence that prompted the agency to look into it

www.statnews.com/202...
1/4