Congrats to Marcus on this years-long effort. Read it at doi.org/10.1038/s41586-025-09159-9

#ChemSky ⚗️🧪 (3/3)

Scheme showing a chemical reaction from Cyclosporin A to homo-Cyclosporin A. The novel one carbon homologation acts on the internal alkene in the WHO essential medicine Cyclosporin A and homologates it to give a novel analog with unexplore properties.

Our methodology demonstrates broad applicability across a diverse range of highly functionalised alkene substrates. It homologates terminal and internal alkenes and complex molecules like Cyclosporine A, enabling the synthesis of analogs with modified ​biological properties. (2/3)

Scheme showcasing and explaining the novel one-carbon alkene homologation. An (allyl)siloxymethylsulfone reagent is attached to the alkene via cross metathesis, deprotected via acid-mediated fragmentation to the sulfinic acid, and undergoes the retro-ene to deliver the homologated alkene. This reaction works across a broad scope of simple and complex alkenes, including monosubstituted, 1,1-disubstituted and 1,2-disubstituted internal alkenes.

Excited to share that our one-carbon alkene homologation has been published in @nature.com. 🎉 Marcus developed a simple reagent that enables the homologation of alkenes by a one-pot cross metathesis-fragmentation-retro-ene cascade giving easy access to the homologated alkene. (1/3) 🧵

Some Items of Interest to Process R&D Chemists and Engineers

Happy to see our Carbonyl Azinylative Amination highlighted in @acs.org OPR&Ds new items of interest. Alex, Roopender and Rachel's work uses in situ generated heteroarylindium species to form diverse heteroarylaklyamines from three readily available starting materials.

pubs.acs.org/doi/10.1021/...

Pd-Catalyzed C–H Activation vs β-H Elimination: An Experimental and Computational Insight into the Reactivity of Tertiary Alkylamines Tertiary alkylamines can coordinate palladium salts and direct C–H activation reactions. However, these tertiary alkylamines can suffer from decomposition through oxidative pathways. This report descr...

Find this work at pubs.acs.org/doi/10.1021/...

A graphic showing a central chemical structure of a palladium-coordinated central N-alkyl piperidine which then undergoes either productive γ-C-H cleavage or decomposition via β-H elimination. DFT structures highlight how an N-Ac amino acid ligand favours the productive γ-C-H cleavage due to geometic restriction around the Pd-centre. Find this work at https://pubs.acs.org/doi/10.1021/acscatal.4c06160

Check out our new work in 3° alkylamine directed #Pd catalysed C-H activation in #ACSCatalysis. Jesus shows how an amino acid ligand favours one CMD pathways to preferentially give γ-C(sp3)-H actiavtion over β-H elimination enabling us to make some strained 4° centres.

#ChemSky 🧪⚗️

Some Items of Interest to Process R&D Chemists and Engineers OR SEARCH CITATIONS

We are thrilled to see our recent work on carbonyl acylative amination be highlighted in #OPRD. Congrats once more to our colleague Dr. Jianzhong Liu, who is starting his own lab at the University of Science and Technology of China (USTC).

#ChemSky ⚗️🧪

pubs.acs.org/doi/10.1021/...

A celebration in the Gaunt Group's lab kitchen including Matthew Gaunt and the newly graduated Dr. Joe Phelps.

Congratulations on Dr. Joe Phelps for passing his viva 🎉🎉!!
#ChemSky 🧪⚗️