Nobel Laureate Professor Sir John Gurdon dies aged 92 It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

Science has lost a GIANT and the world has lost one of the kindest most inspiring people I had the pleasure of knowing. Just an extraordinary man whose curiosity was infectious and whose dry wit will always be memorable- RIP John

www.cam.ac.uk/research/new...

This is such a wonderful perspective from the amazing @fendtlab.bsky.social - in so many ways it was an incredible experience for both myself and @thedawsonlab.bsky.social to have Sarah share her time & brilliant intellect with us - I will always be grateful for the opportunity to host her 🙏🏿

Clinician Scientist Fellowship - Parkville, Melbourne (AU) job with Peter MacCallum Cancer Centre – Parkville | 12839522 Peter Mac is launching Australia’s first clinician-scientist fellowship to advance cancer care, fostering innovation and global collaboration.

Australia completely lacks a dedicated training program for clinician scientists. With the vision and support of VMIAL
@petermaccc.bsky.social is extremely proud to announce the first clinician-scientist fellowship. If you meet the eligibility criteria PLEASE APPLY!
www.nature.com/naturecareer...

It was a huge pleasure having with us on sabbatical!

😁

😁 - that would be awesome! Enid still remembers here zebrafish roots!

Hope you are surviving the madness 🤞🏾

Group Leader - Melbourne (Suburb), Greater Melbourne (Inner) (AU) job with Peter MacCallum Cancer Centre | 12837590 Peter Mac is recruiting a Group Leader to increase the capacity and efficiency of our “discovery to translation” cancer research pipeline.

This is the one for you mate !!!

It would be awesome to have you at our institute!!

www.nature.com/naturecareer...

Postdoctoral Fellow (Bioinformatics & Computational Biology) - Parkville, Melbourne (AU) job with Peter MacCallum Cancer Centre – Parkville | 12837684 Applicants are invited to join an exciting multi-discliplinary research program within Mark Dawson’s Laboratory at the Peter MacCallum Cancer Centre.

We are looking for a talented postdoctoral bioinformatician @thedawsonlab.bsky.social to work with us on single cell multiomics incorporating lineage tracing and spatial technologies- we specifically want someone curious, fearless with a licence to innovate!! Come join us!!

A huge pleasure to host Safia Danovi from @naturegenet.bsky.social @petermaccc.bsky.social - great advice for the students, postdocs & faculty

Four or five people of unknown experience or expertise review it blindly provide a score (out of 7) - that is averaged and provided to the candidate - no discussion takes place - no normalisation of scores takes place - it’s a lottery! Good luck if that is the future in the USA

We have not done grant review panels in Australia for the major grant funding body (NHMRC) since 2020

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing

Where have I heard this before? 🤔 “Let’s cancel grant review panels as they don’t facilitate accountable peer review or education of the next generation” - Ah Yes! that’s the SHAMBOLIC MESS we have where submitting a grant is like buying a lottery ticket! If Trump says it’s a good idea it must be 🤦🏽

Awesome day at the tennis with @sj-dawson.bsky.social - Melbourne at its summer best!

Thanks Lluis

Thank you Chris

Thank you Rob

Thanks Dan

Thanks Yogesh - we were taken on a fascinating journey with this work

Good question Jordan - we did not look at specific TFs but I suspect this response is most pronounced with global inhibition of transcription

Thanks Anna

A huge congratulations to @fendtlab.bsky.social on this amazing body of work!

Thanks to all our collaborators especially the labs of Vi Wickramasinghe & Jeff Chao who co-led the work - very grateful to everyone in @thedawsonlab.bsky.social & @petermaccc.bsky.social for supporting the team

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this!

So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!

www.cell.com/molecular-ce...

Happy holidays from everyone @thedawsonlab.bsky.social

Bioinformatician Postdoctoral Level - VIB Position summary The Chris Marine lab at the VIB Center for Cancer Biology (https://ccb.sites.vib.be/en) is actively seeking a skilled bioinformatician proficient in analyzing and integrating single-...

Looking for an enthusiastic bioinformatician (long-term postdoctoral follow or staff scientist) interested in cancer/melanoma biology and therapy resistance. Data Science (single-cell, spatial multiomics integration), Machine learning, R, Pyhthon... jobso.id/ik9e

I love a bit of "whilst" - sets up an sentence laced with intrigue 😁

Thanks KJ

Thanks Rob

Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia Understanding the molecular pathogenesis of MLL fusion oncoprotein (MLL-FP) leukaemia has spawned epigenetic therapies that have improved clinical outcomes in this often-incurable disease. Using genet...

Thrilled to share a wonderful collaboration with Scott Armstrong, Florian Perner & Shellaina Gordon - exciting times ahead!

www.biorxiv.org/content/10.1...