Hope our work can expand the understandings of SIRT2‘s diverse functionalities. A perfect ending for 2025 and congratulations to all the authors!

Sirtuin 2 Regulates Histone Glycation as a Semi-deglycase Methylglyoxal (MGO) and glyoxal (GO) are reactive carbonyl species (RCS) generated as side products in glycolysis and carbohydrate, protein, and fat catabolism, which are enriched in most cancer cells...

Late update: We are glad to see our new paper in terms of SIRT2's new enzymatic function as a "semi-deglycase" was published on Biochemistry, one of my favorite journals. pubs.acs.org/doi/full/10....

Biocompatible Chemistry: A Plug‐and‐Play Toolbox for Chemical Biology Research The “plug-and-play” nature of biocompatible chemistry makes it a powerful toolbox for investigating complicated biological systems and producing drug leads for clinical usages. This review summarizes...

Biocompatible chemistry is wildly applied in the current chemical biology research. The MCMP student, Adam Lovato, did a topic introduction in our group meeting, and now we made it published on ChemBioChem as a review paper! So proud~ 🍾🎉🥳 chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Regioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation Triazolinedione (TAD) derivatives have been commonly utilized as protection and labeling reagents for indole and phenol moieties via a reversible ene-type reaction. Previous studies showed that the TA...

I am happy to share that we recently developed and named a pH-controlled regioselective rapid ene-type reaction as "RRER" for the specific bioconjugation of a novel epigenetic mark, histone serotonylation. It is now online @rscchembio.rsc.org pubs.rsc.org/en/content/a...

Bidirectional histone monoaminylation dynamics regulate neural rhythmicity - Nature TG2 functions as an eraser and exchanger of H3 monoaminylations, including histaminylation of Gln5 of histone H3.

Excited to see our paper out @nature.com In this work, we discovered that histone monoaminylation dynamics are regulated by a single enzyme (TGM2) and can promote neural rhythmicity by inhibiting the binding of WDR5 to H3 N-terminus.
www.nature.com/articles/s41...

jobrxiv.org/job/purdue-u...

pH-Controlled chemoselective rapid azo-coupling reaction (CRACR) enables global profiling of serotonylation proteome in cancer cells bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Although serotonylation was discovered in the 1950s, a full picture of serotonylated proteins in cells is poorly understood. In this work, we applied pH-controlled CRACR (originally developed by @achemsynbio.bsky.social lab) for profiling serotonylation proteome. www.biorxiv.org/content/10.1...

04/25/2024, Zheng Lab@OSU, good memories and ready for the new journey.