watching the Jersey Mike’s worker make my sandwich

Photo of the wall of a barbecue restaurant, with text printed on the wall that reads: “Ask not what you can do for your country. Ask what kind of MEAT for Dinner”

Went to Korean BBQ for birthday dinner and saw one of my favorite things in the world: inexplicable signage

The deep dive on the cocaine salmon paper you didn't know you needed, with the one and only @tomlumperson.bsky.social

Effing awesome1

E coli: 85 coats underneath a single species name trenchcoat

🎉Excited to share our new preprint!

TIR domains from diverse animals, including human TLR4, are catalytically active and produce cyclic ADP-ribose (cADPR). This enzymatic activity is widespread in animals and conserved across the tree of life.

www.biorxiv.org/content/10.6...

We found that TIR domains in animal immune proteins, including the human TLR4, are enzymes that cleave NAD+ to produce the signaling molecule cADPR

Read our new preprint by talented Bohdana Hurieva: “Conserved catalytic activity of immune TIR domains in animals”

www.biorxiv.org/content/10.6...

Scientists Gave Cocaine to Salmon and You Will Absolutely Believe What Happened Next After scientists exposed wild fish to cocaine and a cocaine metabolite, they observed that, as in the lab, fish on cocaine do not act like normal fish.

Cocaine-Fueled Wild Salmon Swam Twice as Far as Sober Ones www.wired.com/story/cocain...

This girl teaching her new puppy how to go down stairs . 😍

What tasks have you found it good for? Where does it fall short that surprises you?

The email spam problem in 47 flavors

Thank you for saying this so I can feel more justified doing this at work. What do we do about the resume vs. ATS job application slop v slop problems? Is it contributing to the stagnation in the economy?

Funny anecdote when I did tabmaggedon I placed this link: www.science.org/doi/10.1126/... next to this one: theshamblog.com/an-ai-agent-...
The "personality" we give models matters a lot! Both too hot and too cold are Big Problems!

In AI future, computers need to learn to talk to me DANGIT. Or what is the POINT?

If AI does what super-boosters claim, we need to protect all workers because there will be massive displacement.
If it doesn't, then the bubble will pop, and we need to protect the broad swath of workers because it'll be 2008 on steroids.
All roads lead to Rome. podcasts.apple.com/gb/podcast/a...

Everyone knows beef prices are a function of 1) herd size decisions 2 or 3 years ago and 2) fuel costs, right? Like both stats are meaningless but we all know beef is too damn high

It's vitally important for our brand that we don't let AI developers call themselves scientists

TABMAGGEDON!
I closed all my tabs. First time since October. Please clap.

I love that my state sends me a pie chart of tax dollars and that so much is going to schools. I just wish there were a way I didn’t have a flash of panic seeing emails from the dept of revenue

Update: IT came and laid eyes on my phone and fiddled and now I cannot Authenticator OR Slack AND my kitten pictures are gone

Thomas Cole (American, born England, 1801–1848), Distant View of Niagara Falls, Painting of a vast autumn scene with two very small figures in Indigenous clothing standing on a cliff overlooking a massive waterfall in the distance.

Distant View of Niagara Falls, by Thomas Cole (American, born England, 1801–1848)
1830

More info: https://www.artic.edu/artworks/90048

ChatGPT: helping losers do the minimum, peak American pathology edition

I’m not saying it’s the most lovely pic of you, but man did you express what I wanted to

Green River

I mean this is the look I wish I could give him

I feel that the Bluesky devs have sinned and we are all suffering the Seven Plagues of AI until they stop using Claude code

I asked our IT for help and she kept wanting to troubleshoot Duo so I could have Slack and I’m like BUT WHEN MICROSOFT AUTHENTICATOR WILL NOT WORK I CANNOT COMPUTER PLEASE FIX *THAT*

I do think tech companies are underestimating the amount of
- new account fatigue
- new app fatigue
- useless upgrade fatigue
- terms of service fatigue

Here we go again, scientists just making up crazy lies to the public. There aren’t 2.4 million people *in* Sweden. There are only 7 (Greta Thunberg, the four members of ABBA, and two Olympic curlers). Everyone else is an AI phantom.

Kids in the back of a truck "C’mon, get in the mayhem car!" *siren for lightening* "Ahhhh! We’re gonna die!”

Kids are so hilarious