🧐

I don't think the VP or the executive cabinet members are keen on doing that, sadly.

This image is from 2015 and is acquired by the EPIC system on the DSCOVR satellite. Why it is posted with no information I do not know. Many people seem to think this was taken by the Artemis ii crew...
www.nasa.gov/solar-system...

Very nice preprint from the Biggins lab highlighting the importance of the Cbf1 transcription factor in kinetochore assembly and centromere function: www.biorxiv.org/content/10.6...

Still left wondering how Cbf1 and Cbf3 interact, as suggested by the old literature on this matter...

Genetics is the best Journal!

That’s a big IF

Congrats!

Thanks Dave!

Basically you synchronized dna replication entry and now you see pile up of reads at early firing origins then?

I would say more pronounced "waves" might mean more cells stuck in replication as this is what HU arrest followed by sequencing results look like (used to map origins in yeast).

Ah I see your point about the"waves" now. And yes, yeast also show these "waves" near there origins, esp. if you isolated DNA during logarithmic growth.

so in that sense the waves could indeed be due to difference in S-phase progression between pops.

I would interpret these differences as potential aneuploids (general increase to coverage) and the sudden drop as a potential deletion.

but that's coming from a perspective of yeast genomics

I don't see why cell cycle differences would cause whole chromosomes to present differential read coverage

Thank you Adele for this wonderful synthesis of our work !! It was a pleasure to read this morning

Really nice to see @marstonlab.bsky.social's News & Views piece cover the evolution of budding yeast centromeres in @nature.com. Check it out for a clear and concise breakdown of @maxhaase.bsky.social’s new paper and ours! 🧬

What a fantastic News & Views piece in @nature.com from @marstonlab.bsky.social highlighting recent insights into yeast centromere evolution, including the recent paper from @helsenjana.bsky.social and our own.

Thank you Chris! Much of what I learned during my time in Madison shines through here too (yeast diversity, genomics, synteny, and phylogenetics)!

Congratulations to @maxhaase.bsky.social on his recent publication from his time in the Boeke Lab at NYU, where he used methods from the Y1000+ consortium! 🥳 We are very proud to have had him as an undergraduate student in our lab. med.nyu.edu/research/boe...

Fungal-derived cellobiose metabolic pathway fuels T cells to bypass intratumoral glucose competition Solid tumors harbor immunosuppressive microenvironments that inhibit tumor-infiltrating lymphocytes (TILs) through the voracious consumption of glucos…

"Nobody will care about your work about sugar metabolism and transporters in Neurospora crassa"

Nobody can predict what can happen with your work.

www.sciencedirect.com/science/arti...

Yes, my car was cheaper than my recent open access article.

Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with retrotransposon-rich centromeres and that long-terminal-repeat retrotransposons are the genetic substrate.

Nature research paper: Ancient co-option of LTR retrotransposons as yeast centromeres

go.nature.com/4c3kP9A

Congrats!

Global reorganization of genome architecture at the transition to gametogenesis - Nature Structural & Molecular Biology Huang, Rigau and colleagues observe major changes in how DNA is organized in early germ cells before they start developing into sperm or eggs. These results show that germline removes structural ‘memo...

Happy to share our latest paper.

Our findings uncover a unique chromatin architecture and spatial chromosome arrangement in gonadal germ cells and document that alongside global DNA demethylation, the germline epigenetic reprogramming involves reorganisation of the 3D genome.

So excited to share this manuscript led by the inimitable Cara Brand, who discovered that Topoisomerase II evolution causes hybrid female lethality in Drosophila.

Congrats to Cara, @nickbr0wn.bsky.social, Anirban, and
@buszczaklab.bsky.social!

www.biorxiv.org/content/10.6...

Thanks Gudjon!

Thanks Ben!

Thank you Gianni!

Thank you so much Harmit!

Thanks, Hiten!

I agree, it's absolutely incredible they were never recognized for their work by the Nobel committee!

Great thread on budding yeast centromere evolution!

(Bonus points for avoiding “it’s not x; it’s y” sentence structure) 😊

Thank you!

It's not that the sentence structure is too common, it's that its a pedantic way to write.